WDR74 and NUDT3

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		WDR74	NUDT3
Description		WD repeat domain 74	nudix hydrolase 3
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Preribosome, Large Subunit Precursor	Nucleus Cytoplasm Cytosol Synapse Glutamatergic Synapse
	Molecular Function	Protein Binding	Magnesium Ion Binding Endopolyphosphatase Activity Protein Binding Zinc Ion Binding Diphosphoinositol-polyphosphate Diphosphatase Activity Pyrophosphatase Activity Hydrolase Activity Manganese Ion Binding Bis(5'-adenosyl)-hexaphosphatase Activity Bis(5'-adenosyl)-pentaphosphatase Activity Metal Ion Binding Inositol Diphosphate Tetrakisphosphate Diphosphatase Activity Inositol Diphosphate Pentakisphosphate Diphosphatase Activity Inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate Diphosphatase Activity Inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase Activity 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] Diphosphatase Activity 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity
	Biological Process	Blastocyst Formation RRNA Processing RNA Metabolic Process Ribosomal Large Subunit Biogenesis	Cell-cell Signaling Diadenosine Polyphosphate Catabolic Process Diphosphoinositol Polyphosphate Metabolic Process Diphosphoinositol Polyphosphate Catabolic Process RNA Decapping Diadenosine Pentaphosphate Catabolic Process Diadenosine Hexaphosphate Catabolic Process Adenosine 5'-(hexahydrogen Pentaphosphate) Catabolic Process
Pathways			Synthesis of pyrophosphates in the cytosol
Drugs
Diseases
GWAS		Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	A body shape index ( 34021172) Atrial fibrillation ( 29892015) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 20935630 29381148) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 30604766) Fasting insulin ( 34059833) Height ( 25429064 31562340 19893584) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 34021172) Myeloproliferative neoplasms ( 33057200) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		6 interacting genes: CEBPA DLG4 NUDT3 RCHY1 RGS2 YIF1A	36 interacting genes: ALAS1 APEX1 ARL6IP1 ASB13 CCL11 CHCHD3 DBN1 DDR1 DNAJA1 EEF1G FXYD3 HES1 ITFG1 MAF1 MCM5 MEX3B NR2C1 NUDT5 OAT PDCD5 PEX5 PRKD3 RAB17 REEP5 RNF126 RPL17 RPL8 RPLP1 SOX30 TNNT3 TUBA1A TUBGCP4 UBR1 VPS51 WDR74 XPNPEP1
Entrez ID		54663	11165
HPRD ID		08548	14849
Ensembl ID		ENSG00000133316	ENSG00000272325
Uniprot IDs		Q6RFH5	O95989
PDB IDs		8FKP 8FKR 8FKT 8FKV	2FVV 2Q9P 6PCK 6PCL 6WO7 6WO8 6WO9 6WOA 6WOB 6WOC 6WOD 6WOE 6WOF 6WOG 6WOH 6WOI 7TN4 8G9C 8G9D 8T98 8T99 8TF9 8TFA
Enriched GO Terms of Interacting Partners?		Brown Fat Cell Differentiation Kinase Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Fat Cell Differentiation CHOP-C/EBP Complex Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Response To Vitamin B2 C/EBP Complex Positive Regulation Of Proteasomal Protein Catabolic Process P2Y1 Nucleotide Receptor Binding Beta-1 Adrenergic Receptor Binding Regulation Of Grooming Behavior Negative Regulation Of Glycine Import Across Plasma Membrane Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] Diphosphatase Activity Inositol Diphosphate Tetrakisphosphate Diphosphatase Activity Diphosphoinositol Polyphosphate Metabolic Process Inositol Diphosphate Pentakisphosphate Diphosphatase Activity Inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase Activity Diphosphoinositol Polyphosphate Catabolic Process Bis(5'-adenosyl)-hexaphosphatase Activity Diadenosine Hexaphosphate Catabolic Process Inositol Phosphate Catabolic Process Diadenosine Pentaphosphate Catabolic Process Adenosine 5'-(hexahydrogen Pentaphosphate) Catabolic Process Diphosphoinositol-polyphosphate Diphosphatase Activity Endopolyphosphatase Activity Inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate Diphosphatase Activity White Fat Cell Proliferation Adenylate Cyclase Inhibitor Activity Bis(5'-adenosyl)-pentaphosphatase Activity Diadenosine Polyphosphate Catabolic Process Cellular Response To Metal Ion Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex AMPA Glutamate Receptor Clustering Neuroligin Family Protein Binding Error-free Translesion Synthesis Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process NMDA Selective Glutamate Receptor Signaling Pathway Relaxation Of Vascular Associated Smooth Muscle Developmental Maturation Positive Regulation Of Protein Catabolic Process Response To Phenylpropanoid D1 Dopamine Receptor Binding
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