POU2AF1 and CCDC120

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		POU2AF1	CCDC120
Description		POU class 2 homeobox associating factor 1	coiled-coil domain containing 120
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus RNA Polymerase II Transcription Regulator Complex	Cytoplasm Endosome Centriole Cytoskeleton Growth Cone Cell Projection Neuron Projection Centriolar Subdistal Appendage
	Molecular Function	DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding POU Domain Binding	Protein Binding
	Biological Process	Germinal Center B Cell Differentiation Humoral Immune Response Positive Regulation Of Interleukin-6 Production Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Virus	Intracellular Protein Localization Microtubule Anchoring At Centrosome
Pathways
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Celiac disease ( 22057235) Corneal structure ( 23291589) Diverticular disease ( 30177863) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Hodgkin's lymphoma ( 30194254) Low urine pH ( 30476138) Lymphocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Primary biliary cholangitis ( 23000144 28062665) Serum urea levels ( 30808845) Urine pH measurement ( 30476138)
Interacting Genes		55 interacting genes: CCDC120 CIMIP2B DGCR6L FOXD2 GATA2 GCC2 GPS2 GTF2H1 GTF2I HEMK1 HGS HOXC8 HOXC9 ITGB4 KLHL38 KRTAP12-1 KRTAP13-2 KRTAP15-1 KRTAP19-3 KRTAP19-5 KRTAP19-7 MEIS2 MSX2 NAB1 NDUFAF3 NOTCH1 OTX1 PAX8 PITX2 POGZ POU2F1 POU2F2 PTPN11 RAMAC RBM24 RHOXF2 ROR2 SCAND1 SIAH1 SIAH2 SLC22A1 SLC22A2 SMAD2 SUB1 SYK TBX6 TENT5B TFG TLX3 USP2 VGLL3 VPS37C YPEL3 ZNF414 ZNF581	103 interacting genes: AIRIM AKAP8L ARID5A ATP23 BCAS2 BLZF1 BRCA1 CADPS CALCOCO2 CCDC102B CCDC13 CCDC136 CCDC57 CCDC85B CDR2 CEP170P1 CEP55 CKS1B CNFN COG6 CTBP2 CYSRT1 CYTH2 DAZAP2 EFHC2 EIF3F FCHSD2 FOS FOSL1 FSD2 GOLGA2 GOLGA6L9 GPRASP3 HNRNPH1 HOMER3 HOXA1 HSF2BP IFT88 IHO1 INTS11 KASH5 KRT15 KRT31 KRT34 KRT35 KRT38 KRT40 KRTAP13-3 KRTAP19-1 KRTAP6-1 KRTAP6-2 KRTAP6-3 LMNA LMNB2 LMO4 LZTS1 MAGED1 MDFI MED11 METTL27 MID2 MIIP MIPOL1 MKRN3 MRPL38 MTUS2 MYOG NCK2 NEK6 NOTO NXF1 PKP2 PLA2G10 PLAGL2 PLEKHG4 POU2AF1 PRDM6 RABEP1 RBPMS RERE RINT1 RUSC1 SFI1 SMARCB1 SORBS3 SPAG8 STX11 TFIP11 TLE5 TP53BP1 TRAF1 TRIM42 TRIM55 TRIM63 TRIP6 TSC1 TSGA10IP USHBP1 ZDHHC17 ZIM2 ZMAT5 ZNF648 ZRANB1
Entrez ID		5450	90060
HPRD ID		03126	06595
Ensembl ID		ENSG00000110777	ENSG00000147144
Uniprot IDs		Q16633	Q96HB5
PDB IDs		1CQT
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Factor Activity Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Gene Expression Pattern Specification Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II DNA Binding Chromatin Positive Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regionalization Positive Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Nucleus Positive Regulation Of Transcription By RNA Polymerase II Serotonin Transport Positive Regulation Of RNA Metabolic Process Anatomical Structure Morphogenesis Pyrimidine Nucleoside Transmembrane Transporter Activity Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Intermediate Filament Anterior/posterior Pattern Specification Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Putrescine Transmembrane Transporter Activity Negative Regulation Of Developmental Process Positive Regulation Of Macromolecule Metabolic Process Nephron Tubule Development Embryonic Morphogenesis Acetylcholine Transport Epinephrine Transport Spermidine Transmembrane Transport Putrescine Transport Spermidine Transmembrane Transporter Activity Acetylcholine Transmembrane Transporter Activity Renal Tubule Development Kidney Epithelium Development Cell Surface Receptor Signaling Pathway Involved In Heart Development Embryonic Hindlimb Morphogenesis Spermidine Transport Thiamine Transmembrane Transporter Activity Thiamine Transport	Intermediate Filament Protein Binding Identical Protein Binding Intermediate Filament Organization Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cytoskeleton Transcription Coactivator Activity Cytoskeleton Organization Keratin Filament Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Organelle Organization Structural Molecule Activity Structural Constituent Of Cytoskeleton Nuclear Pore Localization
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