TMCO1 and FCGR2A

		TMCO1	FCGR2A
Description		transmembrane and coiled-coil domains 1	Fc gamma receptor IIa
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GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Mitochondrial Membrane Multi-pass Translocon Complex	Plasma Membrane External Side Of Plasma Membrane Membrane Secretory Granule Membrane
	Molecular Function	Calcium Channel Activity Protein Binding Ribosome Binding	Protein Binding IgG Receptor Activity IgG Binding
	Biological Process	Ossification Monoatomic Ion Transport Calcium Ion Transport ER Overload Response Endoplasmic Reticulum Calcium Ion Homeostasis Monoatomic Ion Transmembrane Transport Calcium Ion Transmembrane Transport Multi-pass Transmembrane Protein Insertion Into ER Membrane	Antibody-dependent Cellular Cytotoxicity Immune System Process Cell Surface Receptor Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Fc-gamma Receptor Signaling Pathway Positive Regulation Of Phagocytosis
Pathways			FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis Neutrophil degranulation FCGR3A-mediated IL10 synthesis
Drugs			Cetuximab Etanercept Human immunoglobulin G Abciximab Alemtuzumab Daclizumab Bevacizumab Catumaxomab Sarilumab
Diseases			Systemic lupus erythematosus
GWAS		Glaucoma ( 31959993 21532571 30054594) Glaucoma (high intraocular pressure) ( 33627673) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 33627673 25173105 29891935) Intraocular pressure ( 30054594 31959993 31798171 29785010 29617998 29235454 28073927 25173106 24002674 22570627) Intraocular pressure (corneal compensated) ( 30894546) Medication use (antiglaucoma preparations and miotics) ( 31015401) Refractive error ( 32231278) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993)	Ankylosing spondylitis ( 23749187) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173) Helicobacter pylori serologic status ( 23652523) Hematocrit ( 27863252) Hemoglobin levels ( 32327693) Inflammatory bowel disease ( 28067908 23128233) Kawasaki disease ( 33772158 28886140 22081228) Lipid metabolism phenotypes ( 22286219) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 24532676) Systemic lupus erythematosus ( 26663301 28714469 27399966 26502338 24871463) Takayasu arteritis ( 23830517) Ulcerative colitis ( 28067908 19915573 21297633 20228799)
Interacting Genes		2 interacting genes: AMFR FCGR2A	37 interacting genes: ACTR2 ADAM33 AGPAT4 BLK CDIPT CMTM5 CRP CRYAB CSGALNACT2 CXCL9 F5 FAM3B FCER1A FCER1G FCGR2B FCGR3A FXYD3 FYN GIMAP1 GP6 GRB2 HCK LAT LGALS3 LIMK2 LYN MGST3 MIP NSG1 PIK3R1 SERP2 SHC1 SYK TARDBP TMCO1 UBQLN1 UPK2
Entrez ID		54499	2212
HPRD ID		14243	00906
Ensembl ID		ENSG00000143183	ENSG00000143226
Uniprot IDs		B7Z591 Q9UM00	A0A8V8TPS4 P12318
PDB IDs		6W6L	1FCG 1H9V 3D5O 3RY4 3RY5 3RY6 8CHA
Enriched GO Terms of Interacting Partners?		Regulation Of SREBP Signaling Pathway Protein Alpha-1,2-demannosylation Ubiquitin-ubiquitin Ligase Activity Endoplasmic Reticulum Mannose Trimming Protein K27-linked Ubiquitination BAT3 Complex Binding Derlin-1 Retrotranslocation Complex Acute Inflammatory Response To Antigenic Stimulus Antibody-dependent Cellular Cytotoxicity IgG Receptor Activity Hypersensitivity IgG Binding Ubiquitin-specific Protease Binding Protein Deglycosylation Endoplasmic Reticulum Quality Control Compartment Non-canonical NF-kappaB Signal Transduction Fc-gamma Receptor Signaling Pathway Inflammatory Response To Antigenic Stimulus Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Fc Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction Acute Inflammatory Response Endoplasmic Reticulum Unfolded Protein Response Protein Autoubiquitination Positive Regulation Of Phagocytosis Leukocyte Mediated Cytotoxicity	Fc Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Effector Process Immune Response-regulating Signaling Pathway Leukocyte Degranulation Regulation Of Immune Response Fc Receptor Mediated Stimulatory Signaling Pathway Regulated Exocytosis Negative Regulation Of Inflammatory Response To Antigenic Stimulus Leukocyte Migration Non-membrane Spanning Protein Tyrosine Kinase Activity Lymphocyte Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding Peptidyl-tyrosine Phosphorylation Immune Response Cell Activation IgE Binding Negative Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Adaptive Immune Response Lymphocyte Mediated Immunity Fc-epsilon Receptor Signaling Pathway Neurotrophin TRKA Receptor Binding Leukocyte Activation Mast Cell Degranulation Exocytosis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Immune System Process Membrane Defense Response Negative Regulation Of Immune Response Ephrin Receptor Binding Regulation Of Reactive Oxygen Species Metabolic Process Leukocyte Mediated Immunity Immune Response-activating Signaling Pathway Regulation Of Cell Activation Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Response To Stress Hypersensitivity Immunoglobulin Mediated Immune Response Secretion By Cell Response To Other Organism Regulation Of Transport Activation Of Immune Response IgG Binding Defense Response To Symbiont B Cell Mediated Immunity
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