DGCR8 and USP51

Number of citations of the paper that reports this interaction (PubMedID 34188037)
86

Data Source:
BioGRID (pull down)

		DGCR8	USP51
Description		DGCR8 microprocessor complex subunit	ubiquitin specific peptidase 51
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Postsynaptic Density Nuclear Body Site Of Double-strand Break Microprocessor Complex Glutamatergic Synapse	Nucleus Chromosome
	Molecular Function	RNA Binding Double-stranded RNA Binding Protein Binding Heme Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Primary MiRNA Binding Protein-RNA Adaptor Activity	Chromatin Binding Cysteine-type Deubiquitinase Activity Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Histone Binding Metal Ion Binding Histone H2A Deubiquitinase Activity
	Biological Process	DNA Damage Response Primary MiRNA Processing Regulation Of Stem Cell Proliferation Positive Regulation Of Pre-miRNA Processing	DNA Repair Proteolysis DNA Damage Response Regulation Of Cell Cycle Process Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Deubiquitination DNA Repair-dependent Chromatin Remodeling Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		MicroRNA (miRNA) biogenesis Transcriptional Regulation by MECP2
Drugs
Diseases
GWAS		Adult body size ( 32376654) Metabolite levels ( 23823483) Serum metabolite levels ( 23093944)	Educational attainment (years of education) ( 30038396) Mean corpuscular volume ( 29403010) Smoking initiation ( 24665060)
Interacting Genes		6 interacting genes: APP DROSHA MEOX2 RNF10 RNF168 USP51	11 interacting genes: CDK4 CDK6 DGCR8 ELOC H2AC20 H2AC4 H2BC3 PJA1 USP15 USP21 USP28
Entrez ID		54487	158880
HPRD ID		09913	07167
Ensembl ID		ENSG00000128191	ENSG00000247746
Uniprot IDs		Q8WYQ5	Q70EK9
PDB IDs		1X47 2YT4 3LE4 5B16 6LXD 6LXE 6V5B 6V5C 7CNC 9ASM 9ASN 9ASO 9ASP 9ASQ
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Positive Regulation Of Macromolecule Metabolic Process Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Regulation Of Primary Metabolic Process Chromatin Remodeling Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Response To Calcium Ion Regulation Of MiRNA Metabolic Process Amylin Binding Regulation Of Macromolecule Metabolic Process Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Defense Response To Gram-positive Bacterium Lipoprotein Particle Regulation Of Cellular Response To Stress Chromatin Binding Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Regulation Of Nervous System Process Microglia Development Defense Response To Gram-negative Bacterium Positive Regulation Of G Protein-coupled Receptor Internalization Microprocessor Complex Ribonuclease III Activity DNA Repair-dependent Chromatin Remodeling Histone Ubiquitin Ligase Activity Histone H2AK15 Ubiquitin Ligase Activity Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Cell Activation Involved In Immune Response Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Regulation Of Metabolic Process Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Somite Specification Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane	Chromatin Remodeling Structural Constituent Of Chromatin Cysteine-type Deubiquitinase Activity Protein Deubiquitination Nucleosome Protein Modification By Small Protein Removal Cysteine-type Peptidase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Chromatin Organization Post-translational Protein Modification Regulation Of Post-transcriptional Gene Silencing Regulation Of MiRNA-mediated Gene Silencing Deubiquitinase Activity Cyclin Binding Nucleus Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleoplasm Positive Regulation Of Fibroblast Proliferation Cyclin D2-CDK6 Complex Epigenetic Regulation Of Gene Expression Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cyclin D1-CDK4 Complex Cyclin D3-CDK4 Complex Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Protein Heterodimerization Activity Negative Regulation Of Antifungal Innate Immune Response Microprocessor Complex Positive Regulation Of Pre-miRNA Processing Nuclear Body Regulation Of Fibroblast Proliferation Cyclin D2-CDK4 Complex Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Modification Process Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Cell Cycle Phase Transition Target-directed MiRNA Degradation Elongin Complex Peptidase Activity Protein K27-linked Deubiquitination Protein-RNA Adaptor Activity Cellular Response To Ionomycin Gliogenesis Negative Regulation Of Monocyte Differentiation Cell Dedifferentiation Heterochromatin Formation DeNEDDylase Activity
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