RNF216 and RIPK1

Number of citations of the paper that reports this interaction (PubMedID 11854271)
0

Data Source:
HPRD (two hybrid, in vivo)

		RNF216	RIPK1
Description		ring finger protein 216	receptor interacting serine/threonine kinase 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Clathrin-coated Vesicle Cytoplasmic Vesicle	Cytoplasm Mitochondrion Cytosol Plasma Membrane Endosome Membrane Membrane Death-inducing Signaling Complex Protein-containing Complex Receptor Complex Ripoptosome
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity Death Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Ubiquitin Protein Ligase Binding Signaling Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Death Domain Binding Protein Serine Kinase Activity
	Biological Process	Apoptotic Process Protein Ubiquitination Negative Regulation Of Type I Interferon Production Regulation Of Interferon-beta Production Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Defense Response To Virus By Host Protein K48-linked Ubiquitination	MAPK Cascade Positive Regulation Of Protein Phosphorylation Apoptotic Process Inflammatory Response Response To Oxidative Stress Signal Transduction Canonical NF-kappaB Signal Transduction Positive Regulation Of Gene Expression Programmed Cell Death Protein Catabolic Process Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Tumor Necrosis Factor-mediated Signaling Pathway Response To Tumor Necrosis Factor Intracellular Signal Transduction Peptidyl-serine Autophosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Macrophage Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Protein Autophosphorylation Positive Regulation Of Inflammatory Response Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Necroptotic Process Positive Regulation Of Necroptotic Process Negative Regulation Of Necroptotic Process Positive Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Interleukin-6-mediated Signaling Pathway T Cell Apoptotic Process Necroptotic Process Cellular Response To Hydrogen Peroxide Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Extrinsic Apoptotic Signaling Pathway Programmed Necrotic Cell Death Ripoptosome Assembly Necroptotic Signaling Pathway Positive Regulation Of Execution Phase Of Apoptosis Ripoptosome Assembly Involved In Necroptotic Process Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of MiRNA Processing Amyloid Fibril Formation Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Negative regulators of DDX58/IFIH1 signaling	Caspase activation via Death Receptors in the presence of ligand TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 TRIF-mediated programmed cell death TRP channels Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Regulation of necroptotic cell death Ub-specific processing proteases Ovarian tumor domain proteases Dimerization of procaspase-8 TNF signaling TLR3-mediated TICAM1-dependent programmed cell death NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 IKK complex recruitment mediated by RIP1 Potential therapeutics for SARS Microbial modulation of RIPK1-mediated regulated necrosis SARS-CoV-1-mediated effects on programmed cell death Defective RIPK1-mediated regulated necrosis
Drugs			Fostamatinib
Diseases
GWAS		Heel bone mineral density x serum urate levels interaction ( 34046847) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465)	Cerebral white matter volume ( 31530798) Idiopathic osteonecrosis of the femoral head ( 28000841)
Interacting Genes		33 interacting genes: AGFG1 BRCA1 CAPN15 DYRK1A FAM168A FLNB KIR2DL4 MAPK1 MORC3 OPTN RIPK1 RNF11 STAU2 SUMO2 TLR3 TLR4 TLR5 TLR9 TNFAIP3 TRAF3 UBAC1 UBASH3A UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2L3 UBE2L6 USP5 YOD1 ZFAND2A	57 interacting genes: ANKRD13A CASP8 CCDC50 CDC42BPB CFLAR CRADD CTNNB1 EGFR FADD FAS GMPR H2BC13 HSP90AA1 IKBKE IKBKG ITCH MAP3K1 MAP3K14 MAP3K3 MAP3K8 MTDH NFKB1 NUMBL OTUD1 PDXK PPDPF PRP4K PTK2 PXDC1 RIPK3 RNF11 RNF216 RPA1 SQSTM1 TAX1BP1 TBK1 TICAM1 TNF TNFAIP3 TNFRSF10A TNFRSF10B TNFRSF1A TRADD TRAF1 TRAF2 TRAF3 TRAF5 TRAF6 TRIM38 TRIM72 TRPC4AP UBE2N USP21 WRNIP1 YOD1 ZFAND5 ZNHIT1
Entrez ID		54476	8737
HPRD ID		15550	04583
Ensembl ID		ENSG00000011275	ENSG00000137275
Uniprot IDs		A8K8N1 Q9NWF9	Q13546
PDB IDs		7M4M 7M4N 7M4O 8EB0	4ITH 4ITI 4ITJ 4NEU 5HX6 5TX5 5V7Z 6AC5 6C3E 6C4D 6HHO 6NW2 6NYH 6OCQ 6R5F 6RLN 7CJB 7FCZ 7FD0 7XMK 7YDX 8I2N
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Modification Process Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Ubiquitin-protein Transferase Activity Protein Metabolic Process Positive Regulation Of Defense Response Proteolysis Proteolysis Involved In Protein Catabolic Process Toll-like Receptor Signaling Pathway Protein Polyubiquitination Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-8 Production Regulation Of Cytokine Production Macromolecule Catabolic Process Regulation Of Interleukin-8 Production Pattern Recognition Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Immune Response-regulating Signaling Pathway Endosome Membrane Innate Immune Response-activating Signaling Pathway Positive Regulation Of Innate Immune Response Positive Regulation Of Protein Metabolic Process Protein K48-linked Ubiquitination Ubiquitin Ligase Complex Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Defense Response Activation Of Innate Immune Response Positive Regulation Of Cytokine Production Immune Response-activating Signaling Pathway Regulation Of Dendritic Cell Cytokine Production Regulation Of Type I Interferon Production Regulation Of Immune Response Protein Autoubiquitination Positive Regulation Of Metabolic Process Activation Of Immune Response Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Protein K6-linked Ubiquitination Response To Stress Positive Regulation Of Interferon-alpha Production Protein K48-linked Deubiquitination Regulation Of Innate Immune Response Positive Regulation Of Inflammatory Response Regulation Of Tumor Necrosis Factor Production Regulation Of Immune System Process	Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cell Death Programmed Cell Death Tumor Necrosis Factor-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Signal Transduction Regulation Of Programmed Cell Death Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Cellular Response To Mechanical Stimulus Tumor Necrosis Factor Receptor Binding Positive Regulation Of Defense Response Response To Mechanical Stimulus Non-canonical NF-kappaB Signal Transduction Signaling Adaptor Activity Apoptotic Signaling Pathway Signal Transduction Ubiquitin Protein Ligase Binding Regulation Of Signal Transduction Intracellular Signal Transduction Activation Of Immune Response Extrinsic Apoptotic Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Death-inducing Signaling Complex Regulation Of Defense Response Regulation Of Immune Response Response To Virus Positive Regulation Of Immune Response Immune System Process TRAIL-activated Apoptotic Signaling Pathway Cytokine-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Response To External Biotic Stimulus Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Activation Of Innate Immune Response Regulation Of Cell Communication Defense Response Immune Response-activating Signaling Pathway Positive Regulation Of DNA-binding Transcription Factor Activity Response To Other Organism Positive Regulation Of Innate Immune Response Positive Regulation Of Immune System Process Regulation Of Immune System Process
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