SEMA5B and TK1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		SEMA5B	TK1
Description		semaphorin 5B	thymidine kinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Nucleus Cytoplasm Cytosol
	Molecular Function	Semaphorin Receptor Binding Chemorepellent Activity	Nucleotide Binding Thymidine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Neural Crest Cell Migration Nervous System Development Axon Guidance Cell Differentiation Positive Regulation Of Cell Migration Axon Extension Detection Of Light Stimulus Involved In Visual Perception Negative Chemotaxis Semaphorin-plexin Signaling Pathway Neuron Projection Guidance Neuron Projection Extension	Nucleobase-containing Compound Metabolic Process Deoxyribonucleoside Monophosphate Biosynthetic Process Thymidine Metabolic Process Thymidine Biosynthetic Process Protein Homotetramerization DNA Biosynthetic Process DNA Synthesis Involved In Mitotic DNA Replication
Pathways		Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins	G1/S-Specific Transcription Pyrimidine salvage
Drugs			Dithioerythritol Thymidine 5'-triphosphate
Diseases
GWAS		Cortex volume ( 31530798) Esophageal cancer ( 21642993) Gut microbiota relative abundance (unclassified genus belonging to family Clostridiaceae) ( 33208821) Serum albumin levels ( 29403010) Total grey matter volume ( 31530798)	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Leukocyte telomere length ( 32109421) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 27863252 28957414 32888494)
Interacting Genes		8 interacting genes: ANXA7 C11orf58 FAM118B MRPL44 NUDT21 SMN1 SPRY2 TK1	167 interacting genes: A1BG A2M AAMP ABHD4 ACTB ACTL6B ACTR1B ADAMTS10 ADD1 AGAP1 ALAS1 ALB APLP1 APP ARFGAP1 ATG16L2 ATP5F1B ATP6V1A ATXN3 BAG6 BOLA2 BOLA2B CARHSP1 CCDC90B CDC20 CDK1 CDK4 CDKN1A CENPB CFTR CHGB CLEC3B COL11A2 COL4A2 COL4A5 COPS6 CPNE6 CRIP2 CRMP1 CSAD DACT1 DALRD3 DCAF13 DCAF7 DDAH2 DEAF1 DMPK DOCK7 DRAP1 DUS2 DYNC1I1 DYNC2I1 DYNLT2B EEF1A1 EIF3G EIF4A2 EIF6 ERG28 EXT2 EZH2 F13A1 FAF1 FAM20C FBN3 FGB FLAD1 FST FZR1 GAPDH GDF9 GDI1 GET3 GLB1 GPCPD1 HADHB HERC3 HMGXB3 HSPBAP1 IER3IP1 IGHM IMMT INPP5K INTS11 ITSN1 JADE1 JMJD1C KDM6B KIF21B KIF5A KLHL23 KLHL5 KMT2B LRIF1 MAGEA4 MAST2 MED31 METTL23 MKI67 MPP1 MPPED1 MRFAP1 MRPL20-AS1 MRPL37 MSH2 NEUROD2 NGFR NKIRAS2 NMT2 NRBP1 ODC1 PAAF1 PDE4DIP PJA1 PKM PLD3 PLXNA3 PPP4C PRMT1 PROC PSME1 PTPN4 PTPRK QARS1 RBBP4 RBM48 REX1BD RPA1 RPL13 RPS2 RUVBL1 RXRA SDF4 SEMA5B SEPTIN6 SETDB1 SEZ6L2 SMC5 SNX1 SP110 SULT1A3 SUMO2 SUMO3 TAF1C THOC3 TIAM2 TLE1 TMSB4X TP53 TRIM46 TRMT2A TSC2 TTC38 TUBA1A TUBB2A TUBB3 TYK2 UBC UNC119 UPF2 USP4 VMA22 WDR18 WDR73 WIZ ZBTB16 ZNF431 ZXDC
Entrez ID		54437	7083
HPRD ID		15322	01771
Ensembl ID		ENSG00000082684	ENSG00000167900
Uniprot IDs		A0A3B3IRP9 A0A3B3IT43 B7Z2B3 C9JKR3 Q9P283	A0A384MDV9 K7ERV3 K7ES52 P04183
PDB IDs			1W4R 1XBT 2ORV 2WVJ
Enriched GO Terms of Interacting Partners?		RNA Binding Chromaffin Granule Membrane Cajal Body Nuclear Body DNA Synthesis Involved In Mitotic DNA Replication Thymidine Metabolic Process Protein Tetramerization Thymidine Biosynthetic Process Thymidine Kinase Activity Bud Elongation Involved In Lung Branching Regulation Of Lens Fiber Cell Differentiation Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Ubiquitin-protein Transferase Inhibitor Activity Lung Growth Respiratory System Development Microtubule End Negative Regulation Of Lens Fiber Cell Differentiation MRNA Cleavage Factor Complex Regulation Of Pro-B Cell Differentiation Positive Regulation Of Hematopoietic Progenitor Cell Differentiation MRNA Alternative Polyadenylation Positive Regulation Of Lymphoid Progenitor Cell Differentiation Positive Regulation Of Pro-B Cell Differentiation Ribonuclease III Activity Mitochondrial Translational Elongation Deoxyribonucleoside Monophosphate Biosynthetic Process Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway Response To Phorbol 13-acetate 12-myristate Nucleus SMN Complex RNA Processing Identical Protein Binding Gemini Of Cajal Bodies Pyrimidine Nucleoside Metabolic Process Protein Complex Oligomerization Regulation Of Neurotrophin TRK Receptor Signaling Pathway Branch Elongation Of An Epithelium Paraspeckles Regulation Of Lymphoid Progenitor Cell Differentiation Co-transcriptional RNA 3'-end Processing, Cleavage And Polyadenylation Pathway	Cytoplasm Macromolecule Metabolic Process Protein Metabolic Process Platelet Alpha Granule Lumen Chromatin Organization Blood Microparticle Negative Regulation Of Cell Cycle G1/S Phase Transition Chromatin Remodeling Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Extracellular Exosome Cytosol Regulation Of DNA Replication Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein Binding Nucleoplasm Positive Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Transferase Activity Nuclear Matrix Regulation Of Protein Catabolic Process DNA Synthesis Involved In Mitotic DNA Replication Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Macromolecule Biosynthetic Process Chromosome, Telomeric Region Positive Regulation Of Protein Metabolic Process Cytoskeleton Negative Regulation Of Cell Cycle Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein Tag Activity Developmental Process Growth Cone Protein Modification Process Cellular Response To Norepinephrine Stimulus Response To Norepinephrine Mitotic DNA Damage Checkpoint Signaling Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Oocyte Growth
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