EXOSC10 and CHPF

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		EXOSC10	CHPF
Description		exosome component 10	chondroitin polymerizing factor
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Euchromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane Small-subunit Processome Nucleolar Exosome (RNase Complex)	Golgi Membrane Cytoplasm Mitochondrion Mitochondrial Matrix Golgi Apparatus Cytosol Membrane Golgi Cisterna Membrane
	Molecular Function	Nucleotide Binding 3'-5'-RNA Exonuclease Activity Nucleic Acid Binding RNA Binding Single-stranded RNA Binding Nuclease Activity Exonuclease Activity RNA Exonuclease Activity Protein Binding 3'-5' Exonuclease Activity Hydrolase Activity Metal Ion Binding Telomerase RNA Binding	Protein Binding Acetylgalactosaminyltransferase Activity Transferase Activity Glycosyltransferase Activity Metal Ion Binding Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase Activity N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Maturation Of 5.8S RRNA Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nuclear-transcribed MRNA Catabolic Process Nucleobase-containing Compound Metabolic Process DNA Repair RRNA Processing RNA Processing RNA Catabolic Process DNA Damage Response Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Ribosomal Small Subunit Biogenesis Nuclear MRNA Surveillance CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Polyadenylation-dependent SnoRNA Catabolic Process Nuclear Polyadenylation-dependent SnRNA Catabolic Process TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent CUT Catabolic Process Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process Histone MRNA Catabolic Process Poly(A)-dependent SnoRNA 3'-end Processing Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of MRNA Cis Splicing, Via Spliceosome	Chondroitin Sulfate Proteoglycan Biosynthetic Process
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay	CS-GAG biosynthesis
Drugs
Diseases
GWAS		Beard thickness ( 26926045) Heel bone mineral density ( 30598549) Intraocular pressure ( 29617998)
Interacting Genes		40 interacting genes: ALDH1B1 B9D1 CEBPA CHPF CIB1 DIS3 DXO EIF3M EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 FERMT3 FOXRED1 IMMT LCAT LSM2 LSM8 MPHOSPH6 NOMO1 NOMO2 PALS2 PTGES2 RPE RUVBL2 SCRIB SKIC2 SSRP1 SUMO2 TARDBP TOX4 TTN UPF2 USP16 USP21 USP36 USP7 XRN1 XRN2	19 interacting genes: ARHGEF5 ATG9A BTRC CERS5 EXOSC10 EXOSC6 GLB1L ITGB2 LCOR LINC00839 NKX3-1 NPBWR2 PIN1 PRKN RAC2 RNF25 SKIL SMAD9 TUBA4B
Entrez ID		5394	79586
HPRD ID		16180	10829
Ensembl ID		ENSG00000171824	ENSG00000123989
Uniprot IDs		Q01780	Q8IZ52
PDB IDs		2CPR 3SAF 3SAG 3SAH 6D6Q 6D6R 7MQA
Enriched GO Terms of Interacting Partners?		Nuclear MRNA Surveillance MRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process Nuclear Exosome (RNase Complex) RRNA Catabolic Process Exosome (RNase Complex) Nuclear RNA Surveillance RNA Catabolic Process RNA Surveillance Cytoplasmic Exosome (RNase Complex) U4 SnRNA 3'-end Processing Nucleobase-containing Compound Catabolic Process Nucleolar Exosome (RNase Complex) MRNA Metabolic Process RNA Exonuclease Activity RNA Binding Nucleic Acid Metabolic Process Exoribonuclease Complex SnRNA 3'-end Processing RNA Metabolic Process RRNA Metabolic Process Nucleobase-containing Compound Metabolic Process 3'-5'-RNA Exonuclease Activity SnRNA Processing Negative Regulation Of Gene Expression RRNA Processing Macromolecule Metabolic Process SnRNA Metabolic Process Poly(A)-dependent SnoRNA 3'-end Processing RNA 3'-end Processing 5'-3' Exonuclease Activity Macromolecule Catabolic Process RNA Processing DNA Deamination Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Exonuclease Activity Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nucleolus Sno(s)RNA Metabolic Process U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing 5'-3' RNA Exonuclease Activity MRNA 3'-UTR AU-rich Region Binding DNA Modification Cysteine-type Deubiquitinase Activity	Ubiquitin Ligase Activator Activity Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Poly(A)-dependent SnoRNA 3'-end Processing Nuclear MRNA Surveillance Nucleolar Exosome (RNase Complex) Exosome (RNase Complex) Nuclear Exosome (RNase Complex) Sno(s)RNA Metabolic Process Beta-catenin Binding Ubiquitin-specific Protease Binding Regulation Of Dopamine Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Protein Localization Positive Regulation Of Establishment Of Protein Localization Histone Deacetylase Binding Protein K6-linked Ubiquitination Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Exocytosis Regulation Of Phosphorylation Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Nuclear Estrogen Receptor Binding Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Androgen Secretion Regulation Of Intrinsic Apoptotic Signaling Pathway MADS Box Domain Binding Negative Regulation Of Spontaneous Neurotransmitter Secretion Regulation Of Protein Targeting To Mitochondrion Cis-trans Isomerase Activity RNA Surveillance Nuclear RNA Surveillance Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process Integrin AlphaM-beta2 Complex Integrin AlphaX-beta2 Complex Regulation Of Primary Metabolic Process Leukocyte Cell-cell Adhesion Integrin AlphaL-beta2 Complex Regulation Of Macromolecule Biosynthetic Process Intracellular Signal Transduction Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Dorsal Aorta Development Positive Regulation Of Retrograde Transport, Endosome To Golgi SCF Ubiquitin Ligase Complex Negative Regulation Of Intralumenal Vesicle Formation Positive Regulation Of Protein Linear Polyubiquitination
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