PMM2 and SGK2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PMM2	SGK2
Description		phosphomannomutase 2	serum/glucocorticoid regulated kinase 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Cilium Microtubule Cytoskeleton Neuronal Cell Body	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Phosphomannomutase Activity Protein Binding Isomerase Activity Metal Ion Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Potassium Channel Regulator Activity Kinase Activity Transferase Activity Sodium Channel Regulator Activity Protein Serine Kinase Activity
	Biological Process	Mannose Metabolic Process Protein Glycosylation Protein N-linked Glycosylation GDP-mannose Biosynthetic Process GDP-mannose Biosynthetic Process From Mannose GDP-D-mannose Biosynthetic Process From Fructose-6-phosphate	Regulation Of Cell Growth Protein Phosphorylation Response To Oxidative Stress Positive Regulation Of Transporter Activity Intracellular Signal Transduction Regulation Of Cell Population Proliferation
Pathways		Defective PMM2 causes PMM2-CDG Synthesis of GDP-mannose	Stimuli-sensing channels
Drugs
Diseases		Congenital disorders of glycosylation (CDG) type I
GWAS		Glaucoma (high intraocular pressure) ( 25173107)	Daytime sleep phenotypes ( 27126917) Weight ( 34074324)
Interacting Genes		4 interacting genes: ACY3 MEOX2 SGK2 ZC3H7A	10 interacting genes: APP DAPK1 HIRIP3 IL3RA NEDD4 NEDD4L PDPK1 PMM2 PTOV1 SAP130
Entrez ID		5373	10110
HPRD ID		03472	06348
Ensembl ID		ENSG00000140650	ENSG00000101049
Uniprot IDs		A0A0S2Z4J6 O15305 Q59F02	Q9HBY8
PDB IDs		2AMY 2Q4R 7O0C 7O1B 7O4G 7O58 7O5Z
Enriched GO Terms of Interacting Partners?			Negative Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Cation Transmembrane Transport Sodium Channel Inhibitor Activity Potassium Channel Inhibitor Activity Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Sodium Ion Transport Regulation Of Metal Ion Transport Receptor Catabolic Process Regulation Of Monoatomic Ion Transport Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transport Positive Regulation Of Catabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Protein Catabolic Process Neuromuscular Junction Development Regulation Of Toll-like Receptor Signaling Pathway Receptor Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Synapse Organization Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Synapse Organization DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Regulation Of Dendrite Morphogenesis Protein Monoubiquitination Formation Of Structure Involved In A Symbiotic Process 3-phosphoinositide-dependent Protein Kinase Activity H2A-H2B Histone Complex Chaperone Activity Regulation Of Potassium Ion Transmembrane Transport Regulation Of Sodium Ion Transport Negative Regulation Of Cation Transmembrane Transport Receptor Internalization Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Transport Acetylcholine Receptor Activator Activity Regulation Of Protein Catabolic Process Lipoprotein Particle Positive Regulation Of Protein Import Regulation Of Transport Interleukin-3 Receptor Activity Channel Inhibitor Activity Regulation Of Potassium Ion Transport Phosphomannomutase Activity GDP-D-mannose Biosynthetic Process From Fructose-6-phosphate
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