SPA17 and MYL6B

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology)

		SPA17	MYL6B
Description		sperm autoantigenic protein 17	myosin light chain 6B
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cilium External Side Of Plasma Membrane Membrane Motile Cilium Sperm Fibrous Sheath Neuron Projection Sperm Principal Piece	Cytosol Muscle Myosin Complex Myosin Complex Myosin II Complex Unconventional Myosin Complex Extracellular Exosome
	Molecular Function	Protein Binding Calmodulin Binding	Cytoskeletal Motor Activity Calcium Ion Binding Protein Binding Structural Constituent Of Muscle
	Biological Process	Epithelial Cilium Movement Involved In Extracellular Fluid Movement Spermatogenesis Single Fertilization Binding Of Sperm To Zona Pellucida	Muscle Contraction Skeletal Muscle Tissue Development Muscle Filament Sliding
Pathways			Smooth Muscle Contraction
Drugs			4-[4-(2,5-DIOXO-PYRROLIDIN-1-YL)-PHENYLAMINO]-4-HYDROXY-BUTYRIC ACID
Diseases
GWAS		Bipolar disorder ( 20351715)	Asthma ( 31619474)
Interacting Genes		5 interacting genes: ACTN2 AKAP3 AKAP7 MYL6B ROPN1	3 interacting genes: DUX4 KRT72 SPA17
Entrez ID		53340	140465
HPRD ID		12272	14721
Ensembl ID		ENSG00000064199	ENSG00000196465
Uniprot IDs		A0A172Q397 Q15506	P14649
PDB IDs		8J07	1OE9 1W7I 1W7J 7PLT 7PLU 7PLV 7PLW 7PLX 7PLY 7PLZ 7PM0 7PM1 7PM2 7PM5 7PM6 7PM7 7PM8 7PM9 7PMA 7PMB 7PMC 7PMD 7PME 7PMF 7PMG 7PMH 7PMI 7PMJ 7PML
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Potassium Ion Transport Protein Kinase A Binding Structural Constituent Of Muscle Titin Z Domain Binding Intracellular Protein Localization Positive Regulation Of Cation Transmembrane Transport Regulation Of Potassium Ion Transport Actin Filament Uncapping Positive Regulation Of Monoatomic Ion Transmembrane Transport Sperm Motility Flagellated Sperm Motility Cilium Movement Involved In Cell Motility Cilium-dependent Cell Motility Phospholipase C-activating Angiotensin-activated Signaling Pathway Microspike Assembly Positive Regulation Of Monoatomic Ion Transport Cilium Movement FATZ Binding Motile Cilium Structural Constituent Of Postsynaptic Actin Cytoskeleton Channel Activator Activity LIM Domain Binding Sperm Fibrous Sheath Unconventional Myosin Complex Positive Regulation Of Endocytic Recycling Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Postsynaptic Actin Cytoskeleton Positive Regulation Of Actin Filament Depolymerization Negative Regulation Of Protein Localization To Cell Surface Cell Projection Titin Binding Regulation Of Metal Ion Transport Actin Filament-based Process Postsynaptic Density, Intracellular Component Postsynaptic Actin Cytoskeleton Organization Positive Regulation Of Protein Depolymerization Regulation Of Monoatomic Ion Transport Pseudopodium Microtubule-based Movement Acrosome Reaction Sperm Capacitation Muscle Myosin Complex Actin-myosin Filament Sliding Muscle Filament Sliding Angiotensin-activated Signaling Pathway Regulation Of Endocytic Recycling Postsynaptic Cytoskeleton Organization Regulation Of Membrane Potential Positive Regulation Of Cation Channel Activity
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