PKLR and CLEC4G

Number of citations of the paper that reports this interaction (PubMedID 18624398)
0

Data Source:
BioGRID (two hybrid)

		PKLR	CLEC4G
Description		pyruvate kinase L/R	C-type lectin domain family 4 member G
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome Pyruvate Kinase Complex	Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Catalytic Activity Pyruvate Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Potassium Ion Binding Metal Ion Binding Monosaccharide Binding	Virus Receptor Activity Protein Binding D-mannose Binding Carbohydrate Binding Polysaccharide Binding Pattern Recognition Receptor Activity Fructose Binding Carbohydrate Derivative Binding Virus Coreceptor Activity Glycosylated Region Protein Binding
	Biological Process	Response To Hypoxia Glycolytic Process Response To Nutrient Response To Glucose Response To Metal Ion Cellular Response To Insulin Stimulus Response To ATP Pyruvate Biosynthetic Process Response To CAMP Cellular Response To Epinephrine Stimulus	T Cell Mediated Immunity Negative Regulation Of T Cell Mediated Immunity Immune Response Immature T Cell Proliferation In Thymus Negative Regulation Of Immature T Cell Proliferation In Thymus Negative Regulation Of T Cell Proliferation Alpha-beta T Cell Proliferation Negative Regulation Of Alpha-beta T Cell Proliferation Symbiont Entry Into Host Cell Positive Regulation Of Viral Life Cycle
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs		Pyruvic acid 2-Phosphoglycolic Acid beta-D-fructofuranose 1,6-bisphosphate Mitapivat
Diseases		Pyruvate kinase (PK) deficiency, including: Red cell pyruvate kinase (PK) deficiency; Pyruvate kinase hyperactivity
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 24777453) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 28067908) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Major depressive disorder ( 29317602) Red blood cell count ( 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urate levels ( 23263486)	Post bronchodilator FEV1 ( 26634245)
Interacting Genes		7 interacting genes: CLEC4G CPNE7 FNDC3B MUC1 MYOC PCNA PTBP1	27 interacting genes: APOA1 APOH ARL13B ARSA ASGR1 AZU1 CAPN1 CPLX4 CPN1 EBAG9 EIF6 FAM209A FTL GEM IFI35 LRRC4C MAP3K11 MT-CO1 NUP214 PKLR PRDX1 PTPN5 RPSA SHBG SIGLEC12 TNFAIP3 WBP2
Entrez ID		5313	339390
HPRD ID		11841	16721
Ensembl ID		ENSG00000143627	ENSG00000182566
Uniprot IDs		P30613	B7ZKQ2 Q08G24 Q6UXB4 Q6XYD1
PDB IDs		2VGB 2VGF 2VGG 2VGI 4IMA 4IP7 5SC8 5SC9 5SCA 5SCB 5SCC 5SCD 5SCE 5SCF 5SCG 5SCH 5SCI 5SCJ 5SCK 5SCL 5SDT 6NN4 6NN5 6NN7 6NN8 7FRV 7FRW 7FRX 7FRY 7FRZ 7FS0 7FS1 7FS2 7FS3 7FS4 7FS5 7FS6 7FS7 7FS8 7FS9 7FSA 7FSB 7FSC 7FSD 7QDN 7QZU 8TBS 8TBT 8TBU 8XFD
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Negative Regulation Of Cell Adhesion Receptor Tyrosine Kinase Binding Skeletal Muscle Hypertrophy PCNA Complex Replisome Virus Coreceptor Activity PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Poly-pyrimidine Tract Binding Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Glycosylated Region Protein Binding	Extracellular Exosome
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?