PIP4K2A and ODAD2

		PIP4K2A	ODAD2
Description		phosphatidylinositol-5-phosphate 4-kinase type 2 alpha	outer dynein arm docking complex subunit 2
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GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Nucleus Nucleoplasm Cytoplasm Lysosome Autophagosome Cytosol Plasma Membrane Membrane Cell Projection	Cytoplasm Cytoskeleton Cilium Axoneme Cell Projection Ciliary Base
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-4-phosphate 5-kinase Activity 1-phosphatidylinositol-5-phosphate 4-kinase Activity Transferase Activity Protein Homodimerization Activity Phosphatidylinositol Kinase Activity	Protein Binding
	Biological Process	Lipid Metabolic Process Regulation Of Autophagy Megakaryocyte Development Phosphatidylinositol Metabolic Process Negative Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol Phosphate Biosynthetic Process Autophagosome-lysosome Fusion Vesicle-mediated Cholesterol Transport 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Biosynthetic Process Positive Regulation Of Autophagosome Assembly	Cilium Movement Regulation Of Cilium Beat Frequency Determination Of Left/right Symmetry Heart Development Ventricular System Development Cell Projection Organization Outer Dynein Arm Assembly
Pathways		Synthesis of PIPs at the plasma membrane PI5P Regulates TP53 Acetylation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Synthesis of PIPs in the nucleus
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (B-cell precursor) ( 23996088) Acute lymphoblastic leukemia (childhood) ( 29348612) Acute lymphoblastic leukemia in childhood (B cell precursor) ( 29632299) B-cell acute lymphoblastic leukaemia ( 31767839) Height ( 31562340) Lymphocyte percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Positive urgency ( 30718321) Severe influenza A (H1N1) infection ( 26379185)
Interacting Genes		7 interacting genes: BTK GSTK1 MEIS3 ODAD2 RAC1 RPS6KB1 TEC	4 interacting genes: ARHGAP21 NR4A2 OTUD1 PIP4K2A
Entrez ID		5305	55130
HPRD ID		11931	10663
Ensembl ID		ENSG00000150867	ENSG00000169126
Uniprot IDs		P48426	A0A140VKF7 A0A5F9ZH22 B7Z7A1 B7Z7Y0 Q5T2S8
PDB IDs		2YBX 6OSP 6UX9 6YM3 6YM4 6YM5 7N6Z 7N71 7N7J 7N7K 7N7L 7N7M 7N7N 7N7O 8C8C	8J07
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Type I Hypersensitivity Regulation Of B Cell Cytokine Production Monocyte Proliferation Positive Regulation Of Interleukin-17A Production Protein Phosphorylation B Cell Receptor Signaling Pathway T Cell Receptor Signaling Pathway Developmental Process Phosphorylation Protein Kinase Activity B Cell Affinity Maturation Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration Cerebral Cortex GABAergic Interneuron Development Eosinophil Homeostasis Positive Regulation Of Type III Hypersensitivity Protein Tyrosine Kinase Activity Rho GDP-dissociation Inhibitor Binding Regulation Of Cell Adhesion Involved In Heart Morphogenesis Positive Regulation Of Synoviocyte Proliferation Antigen Receptor-mediated Signaling Pathway Cellular Response To Molecule Of Fungal Origin Kinase Activity Negative Regulation Of TORC2 Signaling Histamine Secretion By Mast Cell Response To Molecule Of Fungal Origin Regulation Of Ovarian Follicle Development Erythrocyte Enucleation Cellular Developmental Process Transferase Activity Intracellular Signal Transduction Histamine Secretion Positive Regulation Of Hypersensitivity Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of CGAS/STING Signaling Pathway Nucleotide Binding Positive Regulation Of Protein-containing Complex Assembly Response To Lipid Homeostasis Of Number Of Cells Kinocilium G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Auditory Receptor Cell Morphogenesis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Hepatocyte Growth Factor Receptor Signaling Pathway Engulfment Of Apoptotic Cell	Habenula Development General Adaptation Syndrome 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Biosynthetic Process 1-phosphatidylinositol-5-phosphate 4-kinase Activity Maintenance Of Golgi Location Cellular Response To Corticotropin-releasing Hormone Stimulus 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Metabolic Process
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