PIN1 and WEE1

Number of citations of the paper that reports this interaction (PubMedID 9499405)
60

Data Source:
BioGRID (far western blotting, pull down)

		PIN1	WEE1
Description		peptidylprolyl cis/trans isomerase, NIMA-interacting 1	WEE1 G2 checkpoint kinase
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck Midbody Ciliary Basal Body Glutamatergic Synapse Postsynaptic Cytosol	Nucleus Nucleoplasm Nucleolus Cytoplasm
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Cytoskeletal Motor Activity Protein Binding Beta-catenin Binding Isomerase Activity Cis-trans Isomerase Activity Mitogen-activated Protein Kinase Kinase Binding GTPase Activating Protein Binding Tau Protein Binding Phosphoserine Residue Binding Phosphothreonine Residue Binding Phosphoprotein Binding Ubiquitin Ligase Activator Activity	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding
	Biological Process	Protein Peptidyl-prolyl Isomerization Response To Hypoxia Positive Regulation Of Protein Phosphorylation Protein Targeting To Mitochondrion Regulation Of Mitotic Nuclear Division Rho Protein Signal Transduction Regulation Of Gene Expression Neuron Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Stability Regulation Of Cytokinesis Negative Regulation Of Protein Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Microtubule Polymerization Synapse Organization Protein Stabilization Negative Regulation Of SMAD Protein Signal Transduction Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Hypoxia Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Localization To Nucleus Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Cell Motility	G2/M Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Mitotic Cell Cycle Nuclear Envelope Organization Mitotic Nuclear Membrane Disassembly Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Establishment Of Cell Polarity Positive Regulation Of DNA Replication Neuron Projection Morphogenesis Cell Division Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		ISG15 antiviral mechanism RHO GTPases Activate NADPH Oxidases Regulation of TP53 Activity through Phosphorylation PI5P Regulates TP53 Acetylation Negative regulators of DDX58/IFIH1 signaling	Polo-like kinase mediated events Cyclin E associated events during G1/S transition Cyclin A/B1/B2 associated events during G2/M transition G2/M DNA replication checkpoint Cyclin A:Cdk2-associated events at S phase entry Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Factors involved in megakaryocyte development and platelet production
Drugs		Beta-(2-Naphthyl)-Alanine 3,6,9,12,15,18-HEXAOXAICOSANE	9-HYDROXY-4-PHENYL-6H-PYRROLO[3,4-C]CARBAZOLE-1,3-DIONE 9-HYDROXY-6-(3-HYDROXYPROPYL)-4-(2-METHOXYPHENYL)PYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE N-[4-(2-CHLOROPHENYL)-1,3-DIOXO-1,2,3,6-TETRAHYDROPYRROLO[3,4-C]CARBAZOL-9-YL]FORMAMIDE 4-(2-chlorophenyl)-8-(2-hydroxyethyl)-6-methylpyrrolo[3,4-e]indole-1,3(2H,6H)-dione 3-(9-HYDROXY-1,3-DIOXO-4-PHENYL-2,3-DIHYDROPYRROLO[3,4-C]CARBAZOL-6(1H)-YL)PROPANOIC ACID 8-bromo-4-(2-chlorophenyl)-N-(2-hydroxyethyl)-6-methyl-1,3-dioxo-1,2,3,6-tetrahydropyrrolo[3,4-e]indole-7-carboxamide MK-1775 Fostamatinib
Diseases
GWAS		Sleep duration ( 25469926)	Cutaneous squamous cell carcinoma ( 32041948) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Platelet distribution width ( 32888494)
Interacting Genes		272 interacting genes: ABI2 ADAMTSL4 ADARB1 AJUBA AMOT ANKRD40 AP2A1 APLP1 APP ARHGEF15 ARID5A ATCAY ATN1 ATP5F1B ATP5MJ BAG6 BARD1 BCL11A BCL2 BCL6 BCLAF1 BRCA1 BRD8 BTG2 C3orf36 CAPRIN1 CARHSP1 CASP6 CBFA2T3 CBS CBY2 CCDC184 CCDC33 CCDC6 CCDC88B CCDC90B CCNB1 CCNE1 CCNK CDC25A CDC25C CDC27 CDK1 CDK11A CDK11B CDK12 CDK2 CDK9 CDKN1B CEBPA CENPB CEP55 CEP76 CHAMP1 CHPF CNKSR1 COL11A2 CPEB1 CPNE6 CSAD CSNK2A1 CSNK2A2 CSNK2B CTNNB1 DAB1 DAB2 DDAH2 DDB1 DDX17 DDX24 DDX3X DDX5 DEAF1 DHX15 DMPK DRC12 DYNC1I1 E2F4 EFS EFTUD2 EIF3G EP300 EYA2 FAAP20 FADD FASLG FHL5 FOS FOSL1 FOXI1 FOXN1 FOXO4 FOXP2 FRS2 FUCA2 G3BP1 G3BP2 GGA2 GMEB2 GOLGA2 GOLGA6L9 GPAA1 GPHN GPR152 GRSF1 HADHA HEXIM2 HNRNPC HNRNPH1 HNRNPK HNRNPU HOMEZ HOXA1 IKZF1 IKZF3 INCENP INO80E JAKMIP2 JUN KCTD7 KIF20B KIF5A KIFC3 KLHL20 KMT2B KRT31 KRT34 KRT37 KRT38 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-2 KRTAP5-9 LCN2 LEPR LRIF1 MAP1S MAP3K11 MAPT MCL1 MDFI MED1 MEOX1 MEOX2 MLLT6 MOCS1 MTFR1 MTUS2 MYF5 MYT1 NAB2 NCKIPSD NCOA3 NCOR2 NEK2 NEK6 NELFA NEUROD4 NFATC2 NHERF1 NONO NR4A3 NUP35 NUP62 PABPC1 PAX6 PBX1 PDLIM7 PKIB PKM PKMYT1 PLAGL2 PLEKHG2 PLK1 PML PNMA1 POLR2A PPP1R2 PRPF8 PRRC1 PTOV1 PTPN1 QARS1 RAB4A RAF1 RAI1 RARA RBBP8 RBBP8NL RBPMS RELA REPS1 RNF208 RNPS1 RPL4 RPS6KB1 RUNX2 SCAI SCYL1 SELENOV SEPTIN9 SFPQ SGK1 SHKBP1 SMAD3 SNCAIP SNRNP200 SOCS3 SREK1 SRRM1 SRRM2 SRSF11 SSBP2 SSBP3 SSBP4 SSC5D STIL STK3 SUPT5H TAB3 TBC1D4 TCF12 TCF4 TFG TFPT THAP7 THRAP3 TLE3 TNS2 TOP2A TOX3 TP53 TP63 TP73 TRAF1 TRAF2 TRIM27 TRIM59 TRIP6 TRMT2A TSC2 TSC22D4 TUT1 U2AF2 UBB UBQLN2 UBQLN4 UBXN2B UNC119 VIRMA WEE1 WIZ WRNIP1 XRCC6 ZBTB14 ZBTB2 ZBTB22 ZBTB42 ZBTB7B ZBTB9 ZCCHC10 ZMIZ2 ZNF446 ZNF449 ZNF526 ZNF768 ZNF783	27 interacting genes: AKT1 BRD8 BRSK1 BRSK2 BTRC CASP3 CCNA1 CCNB1 CDC14A CDCA3 CDK1 CDK2 CRK CSNK2A1 EPS15 ERRFI1 FBXW11 MAILR NEDD4 PIN1 PLK1 SKP2 SMAD3 SMURF1 YWHAB YWHAG YWHAZ
Entrez ID		5300	7465
HPRD ID		03031	01907
Ensembl ID		ENSG00000127445	ENSG00000166483
Uniprot IDs		Q13526	P30291 Q86V29
PDB IDs		1F8A 1I6C 1I8G 1I8H 1NMV 1NMW 1PIN 1ZCN 2F21 2ITK 2KBU 2KCF 2LB3 2M8I 2M8J 2M9E 2M9F 2M9I 2M9J 2N1O 2Q5A 2RUC 2RUD 2RUQ 2RUR 2XP3 2XP4 2XP5 2XP6 2XP7 2XP8 2XP9 2XPA 2XPB 2ZQS 2ZQT 2ZQU 2ZQV 2ZR4 2ZR5 2ZR6 3I6C 3IK8 3IKD 3IKG 3JYJ 3KAB 3KAC 3KAD 3KAF 3KAG 3KAH 3KAI 3KCE 3NTP 3ODK 3OOB 3TC5 3TCZ 3TDB 3WH0 4GWT 4GWV 4QIB 4TNS 4TYO 4U84 4U85 4U86 5B3W 5B3X 5B3Y 5B3Z 5BMY 5GPH 5UY9 5VTI 5VTJ 5VTK 6DUN 6O33 6O34 6SVC 6SVE 6SVH 6VAJ 7AOG 7AXN 7AYF 7AZ1 7AZ2 7BDP 7BDT 7BDY 7BFW 7BG3 7BGQ 7BGR 7BGV 7BGW 7EFJ 7EFX 7EKV 7F0M 7NIF 7NIG 7NJ6 7NJ8 7NJA 7NRK 7NRL 7OQ9 7OQA 7SA5 7SUQ 7SUR 8C2G 8C3C 8SG2 8VJD 8VJE 8VJF 8VJG 9INR 9IT1	1X8B 2IN6 2IO6 2Z2W 3BI6 3BIZ 3CQE 3CR0 5V5Y 5VC3 5VC4 5VC5 5VC6 5VD2 5VD4 5VD5 5VD7 5VD8 5VD9 5VDA 7N3U 8BJU 8WDK
Enriched GO Terms of Interacting Partners?		Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Nucleoplasm Identical Protein Binding Protein Binding Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Negative Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Mitotic Cell Cycle Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cytosol Positive Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Nucleic Acid Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Apoptotic Signaling Pathway Chromatin Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Transcription Regulator Complex Regulation Of Cell Cycle Process Negative Regulation Of Biosynthetic Process Cell Death Apoptotic Process RNA Metabolic Process Programmed Cell Death Promoter-specific Chromatin Binding MRNA Metabolic Process Transcription Cis-regulatory Region Binding Nuclear Speck	Cell Cycle G2/M Phase Transition G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Phosphoserine Residue Binding Protein Modification Process Post-translational Protein Modification Regulation Of Cell Cycle Regulation Of Protein Localization To Nucleus Regulation Of Protein Stability Intracellular Signal Transduction Regulation Of Protein Metabolic Process Cytosol Protein Metabolic Process Organelle Organization Positive Regulation Of Protein Metabolic Process Protein Catabolic Process Cellular Response To Stress Protein Targeting SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Protein Localization Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Protein Catabolic Process Protein Localization To Site Of Double-strand Break Signal Transduction G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Metabolic Process Protein Polyubiquitination Macromolecule Catabolic Process Regulation Of Signaling Cell Cycle G1/S Phase Transition Protein Ubiquitination Regulation Of Cell Cycle Phase Transition Cytoplasm Microtubule Cytoskeleton Organization Cell Division Protein Kinase Binding Protein Localization To Organelle Response To Stress DNA Damage Checkpoint Signaling Proteasomal Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Peptidyl-serine Phosphorylation Protein Modification By Small Protein Conjugation Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Intracellular Protein Localization Regulation Of Mitotic Cell Cycle Protein Phosphorylation
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