SERPINB13 and CTSG

Number of citations of the paper that reports this interaction (PubMedID 12504904)
0

Data Source:
HPRD (in vitro)

		SERPINB13	CTSG
Description		serpin family B member 13	cathepsin G
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleoplasm Nucleolus Cytoplasm Cytosol Nuclear Speck Lysosomal Lumen Extracellular Exosome	Extracellular Region Extracellular Space Nucleus Cytoplasm Lysosome Cytosol Plasma Membrane Cytoplasmic Stress Granule Membrane Secretory Granule Extracellular Matrix Azurophil Granule Lumen Extracellular Exosome
	Molecular Function	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity	Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Receptor Ligand Activity Caspase Binding
	Biological Process	Response To UV Negative Regulation Of Endopeptidase Activity Regulation Of Proteolysis Negative Regulation Of Keratinocyte Apoptotic Process	Angiotensin Maturation Monocyte Chemotaxis Protein Phosphorylation Proteolysis Chemotaxis Immune Response Protein Processing Cytokine-mediated Signaling Pathway Antibacterial Humoral Response Extracellular Matrix Disassembly Platelet Activation Response To Lipopolysaccharide Purinergic Nucleotide Receptor Signaling Pathway Neutrophil Activation Defense Response To Bacterium Positive Regulation Of Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Fungus Negative Regulation Of T Cell Activation Protein Maturation Neutrophil-mediated Killing Of Gram-positive Bacterium Cellular Response To Lipopolysaccharide Biofilm Matrix Disassembly Positive Regulation Of Platelet Aggregation
Pathways		RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Metabolism of Angiotensinogen to Angiotensins Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-1 processing Neutrophil degranulation Antimicrobial peptides Suppression of apoptosis Purinergic signaling in leishmaniasis infection
Drugs			Bis-Napthyl Beta-Ketophosphonic Acid 2-[3-({Methyl[1-(2-Naphthoyl)Piperidin-4-Yl]Amino}Carbonyl)-2-Naphthyl]-1-(1-Naphthyl)-2-Oxoethylphosphonic Acid
Diseases
GWAS		Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252)	Congenital heart disease (maternal effect) ( 28468790) Conotruncal heart defects (maternal effects) ( 28468790)
Interacting Genes		9 interacting genes: CTSB CTSG CTSK CTSL DLG2 ELANE PLG PRSS1 PRTN3	31 interacting genes: AGT C3 CAMP CASP7 CXCL12 CXCR4 CYSRT1 ERBIN F2R F2RL1 F2RL2 F5 GP1BA HTR2A IGFBP3 KNG1 KRT31 LRP1 NOTCH2NLA PARP1 PICK1 PPBP SDC1 SELPLG SERPINA1 SERPINA3 SERPINB13 SERPINB4 SERPIND1 THBS1 VCAM1
Entrez ID		5275	1511
HPRD ID		05118	00289
Ensembl ID		ENSG00000197641	ENSG00000100448
Uniprot IDs		A0A0A0MQW3 B7Z447 Q9UIV8	P08311
PDB IDs			1AU8 1CGH 1KYN 1T32 6VTM 7H6G 7H6H 8D4S 8D4V 8D7I 8D7K 8G24 8G25 8G26 9ASX 9ATK
Enriched GO Terms of Interacting Partners?		Peptidase Activity Extracellular Matrix Disassembly Serine-type Endopeptidase Activity Extracellular Matrix Endolysosome Lumen Serine-type Peptidase Activity Collagen Catabolic Process Proteolysis Collagen Metabolic Process Extracellular Space Proteoglycan Binding Hydrolase Activity Extracellular Matrix Organization Extracellular Structure Organization Extracellular Region Biological Process Involved In Interaction With Symbiont Hormone Metabolic Process Leukocyte Migration Cysteine-type Endopeptidase Activity Collagen Binding Protein Metabolic Process Endopeptidase Activity Azurophil Granule Lumen Neutrophil-mediated Killing Of Bacterium Cellular Response To Thyroid Hormone Stimulus Thyroid Hormone Generation Cysteine-type Peptidase Activity Thyroid Hormone Metabolic Process Response To Thyroid Hormone Neutrophil Mediated Immunity Lysosome Protein Processing Regulation Of Hormone Levels Fibronectin Binding Killing By Host Of Symbiont Cells Extracellular Exosome Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Macromolecule Metabolic Process Defense Response To Fungus Response To Fungus Protein Maturation Biofilm Matrix Disassembly Serpin Family Protein Binding Fusion Of Virus Membrane With Host Endosome Membrane Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria External Side Of Plasma Membrane Regulation Of Biological Quality Leukocyte Mediated Cytotoxicity Apical Plasma Membrane	Coagulation Blood Coagulation Hemostasis Thrombin-activated Receptor Activity Extracellular Space Inflammatory Response Regulation Of Body Fluid Levels Extracellular Region Platelet Alpha Granule Lumen Thrombin-activated Receptor Signaling Pathway Serine-type Endopeptidase Inhibitor Activity Endopeptidase Inhibitor Activity Defense Response Peptidase Inhibitor Activity Circulatory System Process Extracellular Exosome Regulation Of Blood Coagulation Regulation Of Hemostasis Regulation Of Biological Quality Positive Regulation Of Programmed Cell Death Signaling Receptor Binding Regulation Of Secretion By Cell Chronic Inflammatory Response Endoplasmic Reticulum Lumen Regulation Of Secretion Response To External Biotic Stimulus Protease Binding Cell Activation Positive Regulation Of Multicellular Organismal Process Killing Of Cells Of Another Organism Leukocyte Migration Proteinase-activated Receptor Activity Response To Cytokine Regulation Of Wound Healing Regulation Of Programmed Cell Death Response To Peptide Platelet Alpha Granule Positive Regulation Of Cell Communication Positive Regulation Of Signaling Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure G Protein-coupled Receptor Signaling Pathway Vascular Process In Circulatory System Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Vessel Diameter Maintenance Regulation Of Tube Size Cellular Response To Cytokine Stimulus Immune System Process Regulation Of Renin Secretion Into Blood Stream Regulation Of Transport Positive Regulation Of Transport
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