ABCB4 and PRKAR2B

		ABCB4	PRKAR2B
Description		ATP binding cassette subfamily B member 4	protein kinase cAMP-dependent type II regulatory subunit beta
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Focal Adhesion Membrane Apical Plasma Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Raft Intercellular Canaliculus Extracellular Exosome	Cytoplasm Centrosome Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Membrane Dendrite Neuronal Cell Body Dendritic Spine Dendritic Shaft Perinuclear Region Of Cytoplasm Extracellular Exosome Ciliary Base Postsynapse Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Phospholipid Transporter Activity ATP Hydrolysis Activity ATPase-coupled Transmembrane Transporter Activity Phosphatidylcholine Floppase Activity Ceramide Floppase Activity ATPase-coupled Intramembrane Lipid Transporter Activity ABC-type Transporter Activity	Nucleotide Binding CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Kinase Binding Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding
	Biological Process	Lipid Metabolic Process Lipid Transport Positive Regulation Of Cholesterol Transport Bile Acid Secretion Phospholipid Translocation Transmembrane Transport Lipid Homeostasis Positive Regulation Of Phospholipid Translocation Ceramide Translocation Response To Fenofibrate Cellular Response To Bile Acid Positive Regulation Of Phospholipid Transport	Fatty Acid Metabolic Process Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Learning Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission Response To Antipsychotic Drug Negative Regulation Of CAMP/PKA Signal Transduction
Pathways		PPARA activates gene expression ABC-family proteins mediated transport Defective ABCB4 causes PFIC3, ICP3 and GBD1	PKA activation PKA activation in glucagon signalling DARPP-32 events Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs			Cyclic adenosine monophosphate
Diseases		Familial cholestasis, including: Progressive familial intrahepatic cholestasis (PFIC); Benign recurrent intrahepatic cholestasis (BRIC); Intrahepatic cholestasis of pregnancy (ICP); North American Indian childhood cirrhosis (NAIC)
GWAS		Alanine aminotransferase levels ( 33547301 33339817) Alanine transaminase levels ( 29403010) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Epithelial ovarian cancer ( 25134534) Gallbladder cancer ( 28274756) Gallstone disease ( 30504769) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Mean reticulocyte volume ( 32888494) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Total cholesterol levels ( 30275531)	Adverse response to lamotrigine and phenytoin ( 22379998) Bladder cancer (smoking interaction) ( 24662972) Blood urea nitrogen levels ( 31152163) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 28552196) Manganese levels ( 26025379) Response to antipsychotic treatment ( 20195266) Triglyceride levels ( 32203549)
Interacting Genes		4 interacting genes: HAX1 PIGY PRKAR2B TESK1	25 interacting genes: ABCB4 AKAP1 AKAP10 AKAP11 AKAP14 AKAP19 AKAP4 AKAP5 AKAP9 CBR1 CFAP91 ECM1 GNAI3 KIF5B LAMB1 LASP1 LRCH4 MT1H NBEA OGT PAK1IP1 RAP2B RPL30 TAF12 TFR2
Entrez ID		5244	5577
HPRD ID		01371	01486
Ensembl ID		ENSG00000005471	ENSG00000005249
Uniprot IDs		P21439	B3KY43 P31323
PDB IDs		6S7P 7NIU 7NIV 7NIW
Enriched GO Terms of Interacting Partners?		Response To Antipsychotic Drug Protein Domain Specific Binding CAMP-dependent Protein Kinase Regulator Activity Podocyte Cell Migration Nuclear-transcribed MRNA Catabolic Process, No-go Decay Regulation Of Actin Filament Organization Lamellipodium Granulocyte Colony-stimulating Factor Signaling Pathway Interleukin-1 Binding Phosphatidylinositol N-acetylglucosaminyltransferase Activity Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Inhibitor Activity Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Granulocyte Differentiation	Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding Negative Regulation Of Adenylate Cyclase Activity CAMP-dependent Protein Kinase Complex
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