PGD and OS9

		PGD	OS9
Description		phosphogluconate dehydrogenase	OS9 endoplasmic reticulum lectin
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Extracellular Exosome	Hrd1p Ubiquitin Ligase Complex Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane
	Molecular Function	Phosphogluconate Dehydrogenase (decarboxylating) Activity Oxidoreductase Activity Carbohydrate Binding Carboxylic Acid Binding NADP Binding	Protease Binding Protein Binding Carbohydrate Binding Glycosylation-dependent Protein Binding
	Biological Process	Pentose-phosphate Shunt NADP+ Metabolic Process NADPH Regeneration Pentose-phosphate Shunt, Oxidative Branch Pentose Biosynthetic Process D-gluconate Metabolic Process	Ubiquitin-dependent Protein Catabolic Process Protein Targeting Protein Retention In ER Lumen Intracellular Protein Localization Protein Ubiquitination Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Response To Endoplasmic Reticulum Stress ERAD Pathway Negative Regulation Of Retrograde Protein Transport, ER To Cytosol
Pathways		Pentose phosphate pathway NFE2L2 regulates pentose phosphate pathway genes	ABC-family proteins mediated transport Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Defective CFTR causes cystic fibrosis ER Quality Control Compartment (ERQC) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Drugs		Gadopentetic acid Dacarbazine Ketotifen 6-phospho-D-gluconic acid Nicotinamide 8-bromo-adenine dinucleotide phosphate
Diseases
GWAS		Hemoglobin ( 32888494) Hepatocellular carcinoma ( 20676096) Metabolite levels ( 23823483)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Multiple sclerosis ( 31604244) Rheumatoid arthritis (ACPA-positive) ( 24532676)
Interacting Genes		10 interacting genes: ALG5 CDC42 CDK4 GBE1 LINC00632 LINC01554 LSM8 OGT OS9 TERF1	28 interacting genes: ACP1 ACVR1B CPNE6 CREB3 DCSTAMP DYSF EGLN1 EGLN3 EIF6 FAIM2 FOXM1 GLS2 HIF1A LINC00839 MEP1B P3H3 PGD PTH RBX1 SCN8A SLC22A1 SMAD2 SNRPD2 SREBF2 TRPV4 USP40 UVRAG ZNF512B
Entrez ID		5226	10956
HPRD ID		01391	17804
Ensembl ID		ENSG00000142657	ENSG00000135506
Uniprot IDs		B4E2U0 P52209	A0A8V8TPZ4 A0A8V8TQI8 A0A8V8TR34 Q13438
PDB IDs		2JKV 4GWG 4GWK 5UQ9	3AIH
Enriched GO Terms of Interacting Partners?		Glycosyltransferase Activity 1,4-alpha-glucan Branching Enzyme Activity Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Glycosylation-dependent Protein Binding Dolichyl-phosphate Beta-glucosyltransferase Activity GBD Domain Binding Storage Vacuole Cyclin D1-CDK4 Complex Cyclin D3-CDK4 Complex Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication	Negative Regulation Of Ossification L-ascorbic Acid Binding Peptidyl-proline 4-dioxygenase Activity Hypoxia-inducible Factor-proline Dioxygenase Activity Regulation Of Ossification Regulation Of Generation Of Precursor Metabolites And Energy Intracellular Oxygen Homeostasis Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Nodal Signaling Pathway I-SMAD Binding Regulation Of MiRNA Transcription Peptide Hormone Secretion Regulation Of Macroautophagy Peptide Secretion Dioxygenase Activity Protein Hydroxylation Regulation Of Myeloid Cell Differentiation Regulation Of MiRNA Metabolic Process Negative Regulation Of Bone Mineralization 2-oxoglutarate-dependent Dioxygenase Activity Hormone Secretion Cellular Response To Stress Positive Regulation Of Transcription By RNA Polymerase II Hormone Transport Peptide Transport Ferrous Iron Binding Positive Regulation Of Myeloid Cell Differentiation Regulation Of Neuron Apoptotic Process Iron Ion Binding Negative Regulation Of MiRNA Transcription Positive Regulation Of Erythrocyte Differentiation Activin Receptor Signaling Pathway Ubiquitin Protein Ligase Binding Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Hypoxia Response To Decreased Oxygen Levels Regulation Of Apoptotic Process Response To Hypoxia Negative Regulation Of Biomineral Tissue Development Assembly Of Large Subunit Precursor Of Preribosome D-gluconate Metabolic Process Phosphogluconate Dehydrogenase (decarboxylating) Activity Type 1 Parathyroid Hormone Receptor Binding Parathyroid Hormone Receptor Binding Monoatomic Cation Channel Activity Positive Regulation Of Protein-containing Complex Disassembly Lytic Vacuole Monocyte Activation Involved In Immune Response Positive Regulation Of Deacetylase Activity Osmosensor Activity
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