PFKL and PFKM

Number of citations of the paper that reports this interaction (PubMedID 6444721)
32

Data Source:
HPRD (in vitro)

		PFKL	PFKM
Description		phosphofructokinase, liver type	phosphofructokinase, muscle
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol 6-phosphofructokinase Complex Membrane Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Nucleus Cytoplasm Cytosol 6-phosphofructokinase Complex Membrane Apical Plasma Membrane Sperm Principal Piece
	Molecular Function	Nucleotide Binding Catalytic Activity 6-phosphofructokinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Kinase Binding Identical Protein Binding Metal Ion Binding Monosaccharide Binding Fructose Binding Fructose-6-phosphate Binding	Nucleotide Binding Catalytic Activity 6-phosphofructokinase Activity Protein Binding ATP Binding Phosphofructokinase Activity Kinase Activity Transferase Activity Kinase Binding Identical Protein Binding Metal Ion Binding Fructose Binding Fructose-6-phosphate Binding
	Biological Process	Fructose 6-phosphate Metabolic Process Glycolytic Process Response To Glucose Fructose 1,6-bisphosphate Metabolic Process Negative Regulation Of Insulin Secretion Glycolytic Process Through Fructose-6-phosphate Canonical Glycolysis	Glycogen Catabolic Process Fructose 6-phosphate Metabolic Process Glycolytic Process Fructose 1,6-bisphosphate Metabolic Process Positive Regulation Of Insulin Secretion Glucose Homeostasis Positive Regulation Of Transcription By RNA Polymerase II Muscle Cell Cellular Homeostasis Carbohydrate Phosphorylation Glycolytic Process Through Fructose-6-phosphate Canonical Glycolysis Glycolysis From Storage Polysaccharide Through Glucose-1-phosphate
Pathways		Neutrophil degranulation Glycolysis	Glycolysis
Drugs
Diseases			Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Rheumatoid arthritis ( 21505073)	Glycated hemoglobin levels ( 34059833) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) Immature fraction of reticulocytes ( 32888494) Longevity (90 years and older) ( 25199915) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Pulse pressure ( 30578418) Red blood cell count ( 32888494)
Interacting Genes		19 interacting genes: APP ATN1 CEBPA COPS6 DNAAF5 GTPBP3 KRTAP10-7 KRTAP4-12 KRTAP5-9 MYD88 PCNT PFKM PRPF40A SHANK3 SUMO2 TESK1 TNFAIP3 USP39 YWHAQ	20 interacting genes: ATP6V0A4 CAV3 CEBPA DLC1 DYNLL1 FHL2 HGS LSM7 MAPK3 NDUFB2 NOS1 PCNA PDGFRL PFKL SFRP2 SFRP4 SIAH1 SUMO2 TEAD4 UBTD1
Entrez ID		5211	5213
HPRD ID		01385	01988
Ensembl ID		ENSG00000141959	ENSG00000152556
Uniprot IDs		P17858 Q7L2M7	A0A024R0Y5 A0A0S2Z4I1 A0A2R8Y891 F8VTQ3 P08237
PDB IDs		7LW1 8W2G 8W2H 8W2I 8W2J	4OMT
Enriched GO Terms of Interacting Partners?		Amyloid-beta Complex Growth Cone Lamellipodium Neuron Projection Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Response To Calcium Ion Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Interleukin-1 Production Regulation Of Tumor Necrosis Factor Production Amylin Binding Positive Regulation Of Protein Catabolic Process Positive Regulation Of Toll Signaling Pathway Regulation Of Interleukin-6 Production Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Long-term Synaptic Potentiation Regulation Of Protein Catabolic Process Regulation Of Inflammatory Response Memory Cytosol Leukocyte Activation Involved In Inflammatory Response Identical Protein Binding Regulation Of Interleukin-1 Beta Production Kinase Binding Nuclear Matrix RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Intermediate Filament Regulation Of Toll-like Receptor 4 Signaling Pathway TIR Domain Binding Toll Binding ATP-dependent Histone Chaperone Activity Induced Systemic Resistance Phosphofructokinase Activity Glycolysis From Storage Polysaccharide Through Glucose-1-phosphate Tolerance Induction To Lipopolysaccharide Protein Modification By Small Protein Removal Negative Regulation Of Toll-like Receptor 5 Signaling Pathway Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Macrophage Differentiation Positive Regulation Of Protein Localization Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Proteolysis Positive Regulation Of Defense Response	Caveola Regulation Of Ubiquitin-dependent Protein Catabolic Process Anatomical Structure Formation Involved In Morphogenesis Heart Trabecula Formation Negative Regulation Of Signaling Negative Regulation Of Transport Negative Regulation Of Cell Communication Negative Regulation Of Potassium Ion Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Z Disc Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Cell Development Myoblast Fusion Regulation Of Cell Communication Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Hematopoietic Stem Cell Proliferation Response To Hormone Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Canonical Wnt Signaling Pathway Wnt-protein Binding Ubiquitin-like Protein Ligase Binding Protein-containing Complex Binding Cellular Developmental Process Sodium Channel Regulator Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of Membrane Repolarization T-tubule Cardiac Muscle Cell Development Regulation Of Sodium Ion Transmembrane Transport Regulation Of Nerve Growth Factor Receptor Activity Regulation Of Proteolysis Syncytium Formation By Plasma Membrane Fusion Negative Regulation Of Signal Transduction Negative Regulation Of Sarcomere Organization Cell-cell Fusion Regulation Of Signal Transduction By Receptor Internalization Cardiac Cell Development Syncytium Formation Negative Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Cell Population Proliferation Regulation Of Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Transcription By RNA Polymerase II Response To Dexamethasone Positive Regulation Of Macromolecule Biosynthetic Process PCNA Complex
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