PEX7 and PEX14

Number of citations of the paper that reports this interaction (PubMedID 10212238)
0

Data Source:
HPRD (in vivo, two hybrid)

		PEX7	PEX14
Description		peroxisomal biogenesis factor 7	peroxisomal biogenesis factor 14
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Peroxisome Peroxisomal Membrane Peroxisomal Matrix Cytosol	Fibrillar Center Nucleus Peroxisome Peroxisomal Membrane Cytosol Membrane Protein-containing Complex Peroxisomal Importomer Complex
	Molecular Function	Peroxisome Matrix Targeting Signal-2 Binding Protein Binding Enzyme Binding Protein Homodimerization Activity	Transcription Corepressor Activity Signaling Receptor Binding Protein Binding Microtubule Binding Protein Transmembrane Transporter Activity Protein-macromolecule Adaptor Activity Identical Protein Binding Beta-tubulin Binding
	Biological Process	Neuron Migration Endochondral Ossification Protein Targeting To Peroxisome Fatty Acid Beta-oxidation Peroxisome Organization Ether Lipid Biosynthetic Process Protein Transport Protein Import Into Peroxisome Matrix	Protein Monoubiquitination Peroxisome Organization Protein Transport Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Docking Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Receptor Recycling Negative Regulation Of Protein Binding Microtubule Anchoring Cellular Response To Reactive Oxygen Species Peroxisome Transport Along Microtubule Protein Unfolding Negative Regulation Of DNA-binding Transcription Factor Activity Protein Import Into Peroxisome Matrix, Substrate Release Negative Regulation Of DNA-templated Transcription Protein-containing Complex Assembly
Pathways		Peroxisomal protein import Peroxisomal protein import	E3 ubiquitin ligases ubiquitinate target proteins Peroxisomal protein import Peroxisomal protein import Class I peroxisomal membrane protein import
Drugs
Diseases		Refsum disease; Heredopathia atactica polyneuritiformis Rhizomelic chondrodysplasia punctata, including: Rhizomelic chondrodysplasia punctata, type I (RCDP1); Rhizomelic chondrodysplasia punctata, type II (RCDP2); Rhizomelic chondrodysplasia punctata, type III (RCDP3)	Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS		Caffeine consumption from coffee or tea ( 33287642) Caffeine consumption from tea ( 33287642) Lymphocyte percentage of white cells ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil percentage of white cells ( 32888494)	Asthma ( 34103634 32296059 27182965) Blond vs. brown/black hair color ( 30531825) Breast cancer ( 29059683 27117709 23535729 23535733) Breast cancer (estrogen-receptor negative) ( 27117709) Breast size ( 27182965) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Facial morphology ( 31763980) Femur bone mineral density x serum urate levels interaction ( 34046847) Hand grip strength ( 29313844) Heel bone mineral density ( 30598549) LDL cholesterol ( 30275531) Male-pattern baldness ( 28196072) Metabolite levels ( 23823483) Optic nerve measurement (rim area) ( 20395239) Prostate cancer ( 25217961) Refractive error ( 32231278) Self-reported allergy ( 23817569) Total cholesterol levels ( 30275531)
Interacting Genes		9 interacting genes: ACAT1 KDM1A PEX13 PEX14 PEX5 PEX5L PHYH PRMT6 STOML2	24 interacting genes: ACACB AFTPH CAMTA1 CBFA2T2 CENPK COPS4 FSD1 GET3 HDAC1 KDM5D MARF1 MED8 MTNR1A NEDD9 NFE2 NFKBIL1 OGT PEX19 PEX26 PEX5 PEX7 SMARCC2 TONSL ZHX1
Entrez ID		5191	5195
HPRD ID		03454	03477
Ensembl ID		ENSG00000112357	ENSG00000142655
Uniprot IDs		A0A7I2V2J8 O00628 Q6FGN1	O75381
PDB IDs			2W84 2W85 4BXU 9GAG
Enriched GO Terms of Interacting Partners?		Protein Import Into Peroxisome Matrix, Docking Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Substrate Release Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Unfolding Peroxisomal Membrane Protein Import Into Peroxisome Matrix Fatty Acid Oxidation Fatty Acid Catabolic Process Lipid Oxidation Establishment Of Protein Localization To Peroxisome Peroxisomal Membrane Transport Peroxisome Matrix Targeting Signal-1 Binding Peroxisome Organization Receptor Recycling Peroxisome Intracellular Protein Transmembrane Transport Lipid Modification Peroxisomal Importomer Complex Peroxisome Targeting Sequence Binding Receptor Metabolic Process Protein Monoubiquitination Carboxylic Acid Catabolic Process Fatty Acid Alpha-oxidation Lipid Catabolic Process Protein Transmembrane Transport Fatty Acid Metabolic Process Cellular Response To Reactive Oxygen Species Small Molecule Metabolic Process Protein-containing Complex Disassembly Monocarboxylic Acid Metabolic Process Response To Reactive Oxygen Species Protein Transmembrane Transporter Activity Cerebral Cortex Cell Migration Cellular Response To Oxidative Stress Telencephalon Cell Migration Forebrain Cell Migration Carboxylic Acid Metabolic Process Cellular Response To Chemical Stress Peroxisomal Matrix Organic Acid Metabolic Process Fatty Acid Beta-oxidation Metanephric Proximal Convoluted Tubule Development Propionyl-CoA Biosynthetic Process C-acetyltransferase Activity Peroxisome Transport Along Microtubule 2-oxobutyrate Catabolic Process Phytanoyl-CoA Dioxygenase Activity Lipid Localization Histone H2AR3 Methyltransferase Activity	Establishment Of Protein Localization To Peroxisome Peroxisomal Membrane Transport Peroxisome Organization Protein Import Into Peroxisome Membrane Protein Targeting To Peroxisome Protein Import Into Peroxisome Matrix Peroxisome Peroxisomal Membrane Peroxisome Membrane Targeting Sequence Binding Nucleoplasm Intracellular Protein Transmembrane Transport Protein Carrier Chaperone Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Unfolding Nucleus Fatty Acid Oxidation Establishment Of Protein Localization To Membrane Protein Transmembrane Transport Protein Localization To Organelle Lipid Oxidation Nucleosome Disassembly Sin3-type Complex Protein-DNA Complex Disassembly Protein-containing Complex Negative Regulation Of Stem Cell Population Maintenance Receptor Recycling Circadian Rhythm Chromatin Organization Lipid Modification Regulation Of Androgen Receptor Signaling Pathway Protein-containing Complex Disassembly Lactic Acid Secretion Intracellular Aspartate Homeostasis Nucleosomal DNA Binding Establishment Of Protein Localization To Organelle Peroxisome Matrix Targeting Signal-2 Binding Negative Regulation Of Lipid Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Receptor Metabolic Process Positive Regulation Of Stem Cell Population Maintenance Peroxisomal Matrix Malonyl-CoA Biosynthetic Process Protein-containing Complex Organization Acetyl-CoA Carboxylase Activity Krueppel-associated Box Domain Binding Positive Regulation Of Immunological Synapse Formation Fatty Acid Beta-oxidation Peroxisome Matrix Targeting Signal-1 Binding
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