CDK12 and SLFN12

		CDK12	SLFN12
Description		cyclin dependent kinase 12	schlafen family member 12
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GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Cyclin K-CDK12 Complex Nucleus Nucleoplasm Cyclin/CDK Positive Transcription Elongation Factor Complex Nuclear Speck Nuclear Cyclin-dependent Protein Kinase Holoenzyme Complex	Nucleus Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Kinase Activity Transferase Activity Protein Kinase Binding Cyclin Binding Protein Serine Kinase Activity	RNA Nuclease Activity Protein Binding Hydrolase Activity Ribosome Binding
	Biological Process	Transcription By RNA Polymerase II MRNA Processing RNA Splicing Positive Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of MAP Kinase Activity Negative Regulation Of MAPK Cascade Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Cellular Response To Estrogen Stimulus Negative Regulation Of Stem Cell Differentiation	RRNA Catabolic Process Apoptotic Signaling Pathway
Pathways		TP53 Regulates Transcription of DNA Repair Genes
Drugs
Diseases
GWAS		Asthma ( 31619474) Blood urea nitrogen levels ( 31152163) Estimated glomerular filtration rate ( 30604766 31152163) Glomerular filtration rate ( 27588450) Glomerular filtration rate (creatinine) ( 26831199 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Lung function (FVC) ( 30061609) Menopause (age at onset) ( 26414677) Refractive error ( 32231278) Triglyceride levels ( 30108155)
Interacting Genes		19 interacting genes: AP1M2 CDKN1A CLK1 DDB1 EWSR1 FNDC8 GSDMB MBP PCDHB14 PCNT PDLIM7 PIN1 POLR2A PRPF40A RPL13 SLFN12 SRPK2 SRSF1 SRSF2	6 interacting genes: CDK12 GSDMB JMJD6 SUV39H1 TRIM55 TRIM63
Entrez ID		51755	55106
HPRD ID		10849	08543
Ensembl ID		ENSG00000167258	ENSG00000172123
Uniprot IDs		H0YLT2 Q9NYV4	Q8IYM2
PDB IDs		4CXA 4NST 4UN0 5ACB 6B3E 6CKX 6TD3 7NXK 8BU1 8BU2 8BU3 8BU4 8BU5 8BU6 8BU7 8BU9 8BUA 8BUB 8BUC 8BUD 8BUE 8BUF 8BUG 8BUH 8BUI 8BUJ 8BUK 8BUL 8BUM 8BUN 8BUO 8BUP 8BUQ 8BUR 8BUS 8BUT 8P81 9FMR	7EG0 7EG1 7EG4 7LRC 7LRD 7LRE
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Splicing Nuclear Speck Nucleolus Nucleic Acid Binding MRNA Metabolic Process Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome	Histone H4R3 Demethylase Activity Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Peptidyl-lysine 5-dioxygenase Activity Histone H3R2 Demethylase Activity Oxidative RNA Demethylation Histone H3K9 Trimethyltransferase Activity ENoSc Complex Transferase Activity Negative Regulation Of Protein Homooligomerization Oxidative RNA Demethylase Activity Protein Demethylase Activity P-TEFb Complex Binding Negative Regulation Of Protein Oligomerization Cyclin K-CDK12 Complex Nuclear Cyclin-dependent Protein Kinase Holoenzyme Complex Cytotoxic T Cell Pyroptotic Cell Death Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Defense Response To Symbiont RDNA Heterochromatin Defense Response To Other Organism Skeletal Muscle Atrophy Histone H3K9me2 Methyltransferase Activity RDNA Heterochromatin Formation RNA Processing Oxidative Demethylation Peptidyl-lysine Hydroxylation Recognition Of Apoptotic Cell Cyclin/CDK Positive Transcription Elongation Factor Complex Wide Pore Channel Activity Diapedesis Skeletal Muscle Adaptation Striated Muscle Atrophy Regulation Of Transcription By Glucose Muscle Atrophy Histone H3K9 Methyltransferase Activity Chromatin Silencing Complex Demethylation Transcription Regulator Activator Activity RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Nuclear Lamina Facultative Heterochromatin Formation Epigenetic Programming In The Zygotic Pronuclei Phagocytosis, Recognition Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Response To Other Organism Granzyme-mediated Programmed Cell Death Signaling Pathway Cardiolipin Binding Titin Binding Contractile Muscle Fiber Protein Hydroxylation
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