WBP11 and CD2BP2

Number of citations of the paper that reports this interaction (PubMedID 28561026)
79

Data Source:
BioGRID (affinity chromatography technology, two hybrid)
HPRD (in vitro)

		WBP11	CD2BP2
Description		WW domain binding protein 11	CD2 cytoplasmic tail binding protein 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Fibrillar Center Nucleus Nucleoplasm U5 SnRNP Cytoplasm Cytosol Nuclear Speck U4/U6 X U5 Tri-snRNP Complex
	Molecular Function	Single-stranded DNA Binding RNA Binding Protein Binding WW Domain Binding	Protein Binding Ribonucleoprotein Complex Binding
	Biological Process	RRNA Processing RNA Processing MRNA Processing RNA Splicing	Spliceosomal Tri-snRNP Complex Assembly MRNA Processing RNA Splicing
Pathways		mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172)	Brain morphology (MOSTest) ( 32665545)
Interacting Genes		38 interacting genes: APBB1 ARF1 C5orf22 CD2BP2 CEBPA CTNNBL1 CYGB DDX17 DDX5 FOXP1 FYN GIGYF2 GRB2 ITSN1 MCRS1 MORN4 NCK2 NOD2 PCBP4 PIK3R1 PPP1CA PPP1CB PPP1CC PQBP1 PRMT2 PRPF40A RBM5 RSPH1 RTN4IP1 RUNX1T1 SEC23A SRC TESC TRAF4 TRIP10 UBASH3A VIM WBP4	22 interacting genes: ACAD11 AKNA AP2M1 CD2 CHRM3 CPSF7 CSNK2A1 LRRK1 NAT10 OGT PRPF6 PSMF1 PTBP3 SF3B4 SFPQ SMU1 SNRPB SNRPN TRAPPC6A TXNL4A WBP11 ZNHIT2
Entrez ID		51729	10421
HPRD ID		18293	05127
Ensembl ID		ENSG00000084463	ENSG00000169217
Uniprot IDs		Q9Y2W2	A0A024QZC1 O95400
PDB IDs		7ABF 7ABG	1GYF 1L2Z 1SYX 4BWS 8Q7Q 8Q7V 8Q7W 8Q7X 8Q91 8RC0
Enriched GO Terms of Interacting Partners?		Nuclear Speck Proline-rich Region Binding Cytosol RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome PTW/PP1 Phosphatase Complex Nucleus RNA Splicing Ribonucleoprotein Complex Binding Cytoplasm Regulation Of RNA Splicing Nucleoplasm MRNA Processing Protein Domain Specific Binding Regulation Of Defense Response Protein-containing Complex Binding Regulation Of Gene Expression Scaffold Protein Binding Entrainment Of Circadian Clock By Photoperiod Alternative MRNA Splicing, Via Spliceosome Regulation Of Metabolic Process Nuclear Androgen Receptor Binding Regulation Of Macromolecule Biosynthetic Process RNA Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Ephrin Receptor Binding Photoperiodism Entrainment Of Circadian Clock Regulation Of RNA Metabolic Process Regulation Of Apoptotic Process MRNA Metabolic Process Regulation Of Innate Immune Response Regulation Of Programmed Cell Death Positive Regulation Of Immune System Process Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Regulation Of Macromolecule Metabolic Process Neurotrophin TRKA Receptor Binding Regulation Of MRNA Metabolic Process Regulation Of Caveolin-mediated Endocytosis Osteoclast Development Regulation Of Nucleobase-containing Compound Metabolic Process Protein Binding Regulation Of Developmental Process Regulation Of Immune System Process Regulation Of MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process Signal Complex Assembly T Cell Costimulation	MRNA Metabolic Process MRNA Processing RNA Splicing RNA Processing MRNA Splicing, Via Spliceosome U2-type Precatalytic Spliceosome RNA Splicing, Via Transesterification Reactions U5 SnRNP RNA Metabolic Process U4/U6 X U5 Tri-snRNP Complex Spliceosomal Complex Assembly Nucleic Acid Metabolic Process Spliceosomal Complex SnRNP Binding U2 SnRNP Nucleobase-containing Compound Metabolic Process Nucleoplasm RNA Binding Negative Regulation Of Proteasomal Protein Catabolic Process U4 SnRNP Protein-containing Complex Assembly Macromolecule Metabolic Process Protein-RNA Complex Assembly Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Small Nuclear Ribonucleoprotein Complex Catalytic Step 2 Spliceosome U2-type Prespliceosome Protein-containing Complex Organization U1 SnRNP Precatalytic Spliceosome Sin3-type Complex Telomerase Holoenzyme Complex U2-type Prespliceosome Assembly U12-type Spliceosomal Complex Negative Regulation Of Protein Catabolic Process U2-type Spliceosomal Complex Negative Regulation Of Proteolysis Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly TRNA Acetylation MRNA N-acetyltransferase Activity TRNA Cytidine N4-acetyltransferase Activity TRNA Wobble Cytosine Modification RRNA Acetylation Involved In Maturation Of SSU-rRNA 18S RRNA Cytidine N-acetyltransferase Activity Neuroblast Delamination Spliceosomal SnRNP Assembly Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Translational Initiation Cellular Component Assembly
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