CYB5R2 and MED20

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CYB5R2	MED20
Description		cytochrome b5 reductase 2	mediator complex subunit 20
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Endoplasmic Reticulum Membrane Membrane	Nucleus Nucleoplasm Mediator Complex Protein-containing Complex Core Mediator Complex
	Molecular Function	Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Protein Binding Oxidoreductase Activity FAD Binding	Transcription Coregulator Activity Transcription Coactivator Activity DNA-directed RNA Polymerase Activity Protein Binding
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Steroid Metabolic Process Bicarbonate Transport Sterol Biosynthetic Process	DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of Transcription Elongation By RNA Polymerase II Skeletal Muscle Cell Differentiation RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II
Pathways		Erythrocytes take up carbon dioxide and release oxygen	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases
GWAS		Blood pressure ( 23972371) Malaria ( 31844061) Metabolite levels ( 23823483)	Hip circumference adjusted for BMI ( 34021172) Mean corpuscular hemoglobin ( 20139978 27863252) Mean corpuscular volume ( 20139978 23263863 27863252) Metabolite levels ( 23823483) Red blood cell count ( 20139978)
Interacting Genes		20 interacting genes: AGR2 CDC23 COIL FANCL FFAR2 GOLGA2 HGS MED20 MEOX2 NFKBID PSMC6 REL SUOX TRAF1 TRAF2 TRIM55 TRIM63 TRIP13 YPEL3 ZNF778	18 interacting genes: ANKS1A CD300C CEBPB CYB5R2 ERP27 ESR1 ESR2 GABPB1 MARK4 MED18 MED29 MED8 PIH1D2 POLR1B PSORS1C2 TRIM69 UBC YY1
Entrez ID		51700	9477
HPRD ID		06435	15638
Ensembl ID		ENSG00000166394	ENSG00000124641
Uniprot IDs		A8K237 Q6BCY4	B3KUJ9 Q9H944
PDB IDs			7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH
Enriched GO Terms of Interacting Partners?			RNA Polymerase II Preinitiation Complex Assembly Transcription Preinitiation Complex Assembly Core Mediator Complex Nuclear Estrogen Receptor Activity Mediator Complex Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription Elongation By RNA Polymerase II Protein-DNA Complex Assembly Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Initiation By RNA Polymerase II Estrogen Response Element Binding Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of DNA-templated Transcription Initiation Mammary Gland Epithelial Cell Proliferation Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of DNA-templated Transcription Elongation Positive Regulation Of RNA Metabolic Process Estrogen Receptor Signaling Pathway Nuclear Steroid Receptor Activity Transcription Coregulator Activity Negative Regulation Of MiRNA Transcription Steroid Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Cellular Response To Estradiol Stimulus Sequence-specific DNA Binding Cellular Response To Interleukin-1 Protein-containing Complex Assembly Nuclear Receptor Activity Regulation Of Transcription By RNA Polymerase II Granuloma Formation C/EBP Complex Immunoglobulin Heavy Chain V-D-J Recombination Nucleologenesis T-helper 1 Cell Activation Transcription Cis-regulatory Region Binding CHOP-C/EBP Complex RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Sodium-dependent Phosphate Transport Positive Regulation Of Macromolecule Biosynthetic Process Prostate Epithelial Cord Elongation Regulation Of MiRNA Transcription Positive Regulation Of Nitric-oxide Synthase Activity Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Protein-containing Complex Organization Response To Prostaglandin F
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