LSM8 and RSC1A1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		LSM8	RSC1A1
Description		LSM8 homolog, U6 small nuclear RNA associated	regulator of solute carriers 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U6 SnRNP U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome Lsm2-8 Complex Ribonucleoprotein Complex	Nucleus Nucleoplasm Golgi Apparatus Plasma Membrane Membrane Cell Junction
	Molecular Function	RNA Binding MRNA Binding Protein Binding U6 SnRNA Binding	Protein Binding Sodium Channel Inhibitor Activity
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing	Negative Regulation Of D-glucose Transmembrane Transport Negative Regulation Of Nucleoside Transport Negative Regulation Of Golgi To Plasma Membrane Protein Transport Negative Regulation Of Transport Negative Regulation Of Protein Localization To Plasma Membrane
Pathways		mRNA Splicing - Major Pathway	SLC-mediated transport of organic cations Intestinal hexose absorption
Drugs
Diseases
GWAS		Anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Glaucoma (primary open-angle) ( 29891935 33627673) Intraocular pressure ( 29617998) Plasma anti-thyroid peroxidase levels ( 29678681) Positive urgency ( 30718321) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Smoking initiation ( 33082346) Smoking status (current vs never) ( 33082346) Triglyceride levels ( 30108155)	Alcoholic chronic pancreatitis ( 28754779)
Interacting Genes		49 interacting genes: ARNT BCKDK COL23A1 DBF4 DCP1A DCP1B DPAGT1 ECHDC2 EFTUD2 EXOSC10 EXOSC6 FERMT3 GMPPA GTF2I HSPA9 IFNLR1 IGHMBP2 ISOC2 ITSN2 KCTD3 LSM2 LSM3 LSM5 LSM6 LSM7 MAPK8IP2 MGA MINDY1 MPRIP MRPL48 MTHFR NAGK NME4 PDCD2 PGD PHF11 RBM5 RPL24 RSC1A1 RSL24D1 SEPTIN10 SEPTIN5 SMU1 SNRNP200 SNRPB SNRPD1 TALDO1 THUMPD3 UPF1	4 interacting genes: LSM8 ODC1 RAD23B RBPJ
Entrez ID		51691	6248
HPRD ID		06288	15994
Ensembl ID		ENSG00000128534	ENSG00000215695
Uniprot IDs		A4D0W0 O95777	Q92681
PDB IDs		3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 7ABG 8H6E 8H6J 8H6K 8H6L 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5
Enriched GO Terms of Interacting Partners?		U2-type Precatalytic Spliceosome U4/U6 X U5 Tri-snRNP Complex Lsm2-8 Complex MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions U6 SnRNP MRNA Catabolic Process Spliceosomal Complex Lsm1-7-Pat1 Complex RNA Catabolic Process RNA Splicing Catalytic Step 2 Spliceosome Nucleobase-containing Compound Metabolic Process RNA Metabolic Process MRNA Processing RNA Processing RNA Binding Ribonucleoprotein Complex Small Nuclear Ribonucleoprotein Complex Precatalytic Spliceosome P-body Nucleobase-containing Compound Catabolic Process Nuclear-transcribed MRNA Catabolic Process Nucleic Acid Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Protein-RNA Complex Assembly Double-stranded DNA Helicase Activity U5 SnRNP Positive Regulation Of MRNA Cis Splicing, Via Spliceosome U12-type Spliceosomal Complex Deadenylation-independent Decapping Of Nuclear-transcribed MRNA U2-type Catalytic Step 2 Spliceosome Spliceosomal Tri-snRNP Complex U1 SnRNP Binding Nucleoplasm Poly(A)-dependent SnoRNA 3'-end Processing 7-methylguanosine Cap Hypermethylation Spliceosomal SnRNP Assembly Regulation Of MRNA Splicing, Via Spliceosome Spliceosomal Complex Assembly Nucleolar Exosome (RNase Complex) 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity Nuclear MRNA Surveillance U4 SnRNP Methylosome Macromolecule Metabolic Process Pentose-phosphate Shunt Regulation Of MRNA Processing Septin Ring	MAML1-RBP-Jkappa- ICN1 Complex Positive Regulation Of Ephrin Receptor Signaling Pathway Club Cell Differentiation Epidermal Cell Fate Specification Endocardium Morphogenesis RNA Polymerase II-specific DNA-binding Transcription Factor Binding Embryonic Organ Development Pulmonary Valve Development Blood Vessel Endothelial Cell Fate Specification Blood Vessel Lumenization Arterial Endothelial Cell Fate Commitment Endothelial Cell Fate Specification Auditory Receptor Cell Fate Commitment Regulation Of Cell Adhesion Involved In Heart Morphogenesis Ornithine Decarboxylase Activity Putrescine Biosynthetic Process From Arginine, Via Ornithine DNA Damage Sensor Activity XPC Complex Endocardium Development Putrescine Biosynthetic Process Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Aortic Valve Development Hair Follicle Maturation Semi-lunar Valve Development Positive Regulation Of Transcription Of Notch Receptor Target Lsm2-8 Complex Sebaceous Gland Development Dorsal Aorta Morphogenesis Putrescine Metabolic Process Animal Organ Development U6 SnRNP Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Ventricular Trabecula Myocardium Morphogenesis Regulation Of Timing Of Cell Differentiation Regulation Of Development, Heterochronic Cardiac Muscle Cell Myoblast Differentiation Endothelial Tube Morphogenesis Heart Field Specification Atrioventricular Canal Development Epithelial Cell Fate Commitment Secondary Heart Field Specification Cardioblast Differentiation Cardiac Left Ventricle Morphogenesis Polyamine Biosynthetic Process Regulation Of Protein Catabolic Process Cellular Response To Interleukin-7 U6 SnRNA Binding Response To Interleukin-7 Specification Of Animal Organ Identity Regulation Of Cell Proliferation Involved In Heart Morphogenesis
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