LSM7 and ARF6

		LSM7	ARF6
Description		LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated	ARF GTPase 6
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U6 SnRNP U12-type Spliceosomal Complex Cytosol U4/U6 X U5 Tri-snRNP Complex U2-type Prespliceosome U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome Spliceosomal Tri-snRNP Complex Lsm2-8 Complex Lsm1-7-Pat1 Complex Ribonucleoprotein Complex	Ruffle Cytoplasm Endosome Early Endosome Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Cell Cortex Endosome Membrane Membrane Endocytic Vesicle Midbody Filopodium Membrane Early Endosome Membrane Cleavage Furrow Cell Projection Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Flemming Body Presynapse Postsynapse Glutamatergic Synapse
	Molecular Function	RNA Binding Protein Binding U6 SnRNA Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Thioesterase Binding Signaling Adaptor Activity
	Biological Process	MRNA Splicing, Via Spliceosome Nuclear-transcribed MRNA Catabolic Process MRNA Processing RNA Splicing	Mitotic Cytokinesis Liver Development Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Cell Adhesion Nervous System Development Regulation Of Neuron Projection Development Positive Regulation Of Neuron Projection Development Protein Transport Vesicle-mediated Transport Cell Differentiation Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Endocytic Recycling Protein Localization To Cell Surface Regulation Of Rac Protein Signal Transduction Protein Localization To Endosome Negative Regulation Of Receptor-mediated Endocytosis Synaptic Vesicle Endocytosis Positive Regulation Of Protein Secretion Cell Division Regulation Of Filopodium Assembly Positive Regulation Of Keratinocyte Migration Regulation Of Dendritic Spine Development Cellular Response To Diacyl Bacterial Lipopeptide Protein Localization To Plasma Membrane Establishment Of Epithelial Cell Polarity Ruffle Assembly Hepatocyte Apoptotic Process Maintenance Of Postsynaptic Density Structure Positive Regulation Of Focal Adhesion Disassembly Erythrocyte Apoptotic Process Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Mitotic Cytokinetic Process Protein Localization To Cleavage Furrow Regulation Of Presynapse Assembly Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Protein Localization To Cell Surface Negative Regulation Of Dendrite Development
Pathways		mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway	TBC/RABGAPs Clathrin-mediated endocytosis MET receptor recycling
Drugs			5'-Guanosine-Diphosphate-Monothiophosphate Guanosine-5'-Diphosphate Myristic acid
Diseases
GWAS		Parkinson's disease ( 28892059)	Erythema nodosum in inflammatory bowel disease ( 24487271) Ferritin levels ( 33491795)
Interacting Genes		25 interacting genes: ARF6 CEBPA DDIT4L EPHA2 EXOSC6 EXOSC8 LDB1 LSM1 LSM2 LSM3 LSM5 LSM6 LSM8 MYH13 NPY1R PFKM RAB29 RASSF5 SMN1 SNRPD3 SNRPF SYT17 TACC1 TCL1B ZSCAN26	47 interacting genes: AGAP1 ALDH5A1 AP1B1 AP2B1 AP3B1 AP3D1 AP3S2 APP ARFIP2 ARHGAP10 ARRB1 ARRB2 ASAP1 ASAP2 ASAP3 ATP6V0C CAPN1 CHRM3 CLTC CYTH1 CYTH2 EXOC5 EZR FILNC1 HTR2A IKBKG ITSN1 LSM7 MEOX2 MGAM MT2A PALS1 PIP5K1A PIP5K1C PLD1 PRPF39 RAB11A RAB11FIP3 RAB11FIP4 RAB11FIP5 RPLP1 SMAP1 SMARCC2 SNCA SPAG9 TOGARAM1 ZNF709
Entrez ID		51690	382
HPRD ID		06287	02714
Ensembl ID		ENSG00000130332	ENSG00000165527
Uniprot IDs		Q9UK45	P62330
PDB IDs		3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 7ABG 8H6E 8H6J 8H6K 8H6L 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5	1E0S 2A5D 2A5F 2A5G 2BAO 2BAU 2J5X 2W83 3LVQ 3LVR 3N5C 3PCR 4FME 4KAX 6BBP 6BBQ 6PAU 7RK3 7XRD
Enriched GO Terms of Interacting Partners?		U4/U6 X U5 Tri-snRNP Complex Lsm2-8 Complex U2-type Precatalytic Spliceosome U6 SnRNP RNA Splicing, Via Transesterification Reactions Lsm1-7-Pat1 Complex MRNA Metabolic Process RNA Splicing MRNA Processing Spliceosomal Complex RNA Processing MRNA Splicing, Via Spliceosome RNA Metabolic Process Precatalytic Spliceosome MRNA Catabolic Process Ribonucleoprotein Complex Nucleobase-containing Compound Metabolic Process RNA Catabolic Process Spliceosomal SnRNP Assembly Nucleobase-containing Compound Catabolic Process Nucleic Acid Metabolic Process Small Nuclear Ribonucleoprotein Complex SMN-Sm Protein Complex RNA Binding Catalytic Step 2 Spliceosome P-body PICln-Sm Protein Complex Spliceosomal Complex Assembly U7 SnRNP 7-methylguanosine Cap Hypermethylation U4 SnRNA 3'-end Processing Nucleolar Exosome (RNase Complex) U4 SnRNP Nuclear MRNA Surveillance Methylosome U6 SnRNA Binding Protein-RNA Complex Assembly Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity RRNA Catabolic Process Nuclear Exosome (RNase Complex) Exosome (RNase Complex) U1 SnRNP Nucleoplasm U5 SnRNP SnRNA 3'-end Processing Nuclear-transcribed MRNA Catabolic Process Macromolecule Catabolic Process U2-type Prespliceosome Assembly U12-type Spliceosomal Complex	Vesicle-mediated Transport Cytoplasmic Vesicle Intracellular Protein Localization Membrane Coat Establishment Of Localization In Cell Trans-Golgi Network Membrane Receptor-mediated Endocytosis Endocytosis Receptor Internalization Clathrin-coated Pit Protein Transport Melanosome Assembly Vesicle-mediated Transport In Synapse Regulation Of Vesicle-mediated Transport Cellular Localization Cytoplasmic Vesicle Membrane Organelle Localization Establishment Of Vesicle Localization Platelet Dense Granule Organization Import Into Cell Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Golgi Membrane Establishment Of Protein Localization Vesicle Localization Clathrin-dependent Endocytosis Cellular Component Assembly Endocytic Vesicle Membrane Synaptic Vesicle Transport Melanosome Organization AP-3 Adaptor Complex Pigment Granule Organization Synaptic Vesicle Endocytosis Clathrin Adaptor Complex Positive Regulation Of Endocytosis GTPase Activator Activity Presynaptic Endocytosis Plasma Membrane Lysosomal Membrane Angiotensin Receptor Binding Golgi Apparatus Establishment Of Organelle Localization Secretion Post-Golgi Vesicle-mediated Transport Secretion By Cell Localization Within Membrane Intracellular Transport Regulation Of Cellular Component Organization Protein Localization To Plasma Membrane Anterograde Synaptic Vesicle Transport Focal Adhesion
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