ARF6 and PIP5K1C

Number of citations of the paper that reports this interaction (PubMedID 12847086)
66

Data Source:
HPRD (in vitro)

		ARF6	PIP5K1C
Description		ARF GTPase 6	phosphatidylinositol-4-phosphate 5-kinase type 1 gamma
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GO Annotations	Cellular Component	Ruffle Cytoplasm Endosome Early Endosome Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Cell Cortex Endosome Membrane Membrane Endocytic Vesicle Midbody Filopodium Membrane Early Endosome Membrane Cleavage Furrow Cell Projection Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Flemming Body Presynapse Postsynapse Glutamatergic Synapse	Phagocytic Cup Uropod Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Adherens Junction Focal Adhesion Endosome Membrane Endomembrane System Membrane Ruffle Membrane Cell Projection Anchoring Junction Presynapse
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Thioesterase Binding Signaling Adaptor Activity	Nucleotide Binding Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-4-phosphate 5-kinase Activity Transferase Activity Phosphatidylinositol Kinase Activity
	Biological Process	Mitotic Cytokinesis Liver Development Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Cell Adhesion Nervous System Development Regulation Of Neuron Projection Development Positive Regulation Of Neuron Projection Development Protein Transport Vesicle-mediated Transport Cell Differentiation Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Endocytic Recycling Protein Localization To Cell Surface Regulation Of Rac Protein Signal Transduction Protein Localization To Endosome Negative Regulation Of Receptor-mediated Endocytosis Synaptic Vesicle Endocytosis Positive Regulation Of Protein Secretion Cell Division Regulation Of Filopodium Assembly Positive Regulation Of Keratinocyte Migration Regulation Of Dendritic Spine Development Cellular Response To Diacyl Bacterial Lipopeptide Protein Localization To Plasma Membrane Establishment Of Epithelial Cell Polarity Ruffle Assembly Hepatocyte Apoptotic Process Maintenance Of Postsynaptic Density Structure Positive Regulation Of Focal Adhesion Disassembly Erythrocyte Apoptotic Process Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Mitotic Cytokinetic Process Protein Localization To Cleavage Furrow Regulation Of Presynapse Assembly Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Protein Localization To Cell Surface Negative Regulation Of Dendrite Development	Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Exocytosis Endocytosis Phagocytosis Chemotaxis Cell Adhesion Synaptic Vesicle Exocytosis Actin Cytoskeleton Organization Neutrophil Chemotaxis Adherens Junction Assembly Phosphatidylinositol Metabolic Process Phosphatidylinositol Phosphate Biosynthetic Process Synaptic Vesicle Endocytosis Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Membrane Organization Clathrin-dependent Endocytosis Cell-cell Adhesion
Pathways		TBC/RABGAPs Clathrin-mediated endocytosis MET receptor recycling	Synthesis of PIPs at the plasma membrane SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Clathrin-mediated endocytosis Regulation of CDH1 posttranslational processing and trafficking to plasma membrane
Drugs		5'-Guanosine-Diphosphate-Monothiophosphate Guanosine-5'-Diphosphate Myristic acid
Diseases			Lethal congenital contractural syndrome (LCCS)
GWAS		Erythema nodosum in inflammatory bowel disease ( 24487271) Ferritin levels ( 33491795)
Interacting Genes		47 interacting genes: AGAP1 ALDH5A1 AP1B1 AP2B1 AP3B1 AP3D1 AP3S2 APP ARFIP2 ARHGAP10 ARRB1 ARRB2 ASAP1 ASAP2 ASAP3 ATP6V0C CAPN1 CHRM3 CLTC CYTH1 CYTH2 EXOC5 EZR FILNC1 HTR2A IKBKG ITSN1 LSM7 MEOX2 MGAM MT2A PALS1 PIP5K1A PIP5K1C PLD1 PRPF39 RAB11A RAB11FIP3 RAB11FIP4 RAB11FIP5 RPLP1 SMAP1 SMARCC2 SNCA SPAG9 TOGARAM1 ZNF709	21 interacting genes: AKT1 AKT2 AP1B1 AP2B1 ARF6 BTK CDH1 CDK1 CDK5 HDHD2 ITGB1 LAPTM4B LRP2 NEDD4 PKD1 RPL36 SMURF1 SNCA SRC TLN1 TLN2
Entrez ID		382	23396
HPRD ID		02714	05834
Ensembl ID		ENSG00000165527	ENSG00000186111
Uniprot IDs		P62330	O60331
PDB IDs		1E0S 2A5D 2A5F 2A5G 2BAO 2BAU 2J5X 2W83 3LVQ 3LVR 3N5C 3PCR 4FME 4KAX 6BBP 6BBQ 6PAU 7RK3 7XRD	2G35 3H1Z 3H85
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Cytoplasmic Vesicle Intracellular Protein Localization Membrane Coat Establishment Of Localization In Cell Trans-Golgi Network Membrane Receptor-mediated Endocytosis Endocytosis Receptor Internalization Clathrin-coated Pit Protein Transport Melanosome Assembly Vesicle-mediated Transport In Synapse Regulation Of Vesicle-mediated Transport Cellular Localization Cytoplasmic Vesicle Membrane Organelle Localization Establishment Of Vesicle Localization Platelet Dense Granule Organization Import Into Cell Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Golgi Membrane Establishment Of Protein Localization Vesicle Localization Clathrin-dependent Endocytosis Cellular Component Assembly Endocytic Vesicle Membrane Synaptic Vesicle Transport Melanosome Organization AP-3 Adaptor Complex Pigment Granule Organization Synaptic Vesicle Endocytosis Clathrin Adaptor Complex Positive Regulation Of Endocytosis GTPase Activator Activity Presynaptic Endocytosis Plasma Membrane Lysosomal Membrane Angiotensin Receptor Binding Golgi Apparatus Establishment Of Organelle Localization Secretion Post-Golgi Vesicle-mediated Transport Secretion By Cell Localization Within Membrane Intracellular Transport Regulation Of Cellular Component Organization Protein Localization To Plasma Membrane Anterograde Synaptic Vesicle Transport Focal Adhesion	Regulation Of Cellular Localization Positive Regulation Of Transport Regulation Of Cellular Component Organization Establishment Of Localization In Cell Positive Regulation Of Protein Localization Regulation Of Protein Localization Cell Junction Organization Regulation Of Transport Intracellular Protein Transport Membrane Synaptic Vesicle Endocytosis Intracellular Protein Localization Regulation Of Protein Catabolic Process Presynaptic Endocytosis Plasma Membrane Vesicle-mediated Transport Cellular Localization Regulation Of Protein Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Endocytosis Regulation Of Protein Localization To Cell Periphery Regulation Of Synapse Organization Protein Localization To Membrane Receptor Internalization Receptor Catabolic Process Regulation Of Protein Localization To Membrane Receptor-mediated Endocytosis Protein Transport Cell Cortex Phospholipase Binding Positive Regulation Of Protein Localization To Cell Periphery Regulation Of Vesicle-mediated Transport Positive Regulation Of Catabolic Process Protein Localization To Plasma Membrane Actin Cytoskeleton Organization Positive Regulation Of Protein Localization To Membrane Cellular Component Assembly Intracellular Transport Vesicle-mediated Transport In Synapse Cell Adhesion Import Into Cell Positive Regulation Of Protein Localization To Nucleus Ruffle Membrane Ionotropic Glutamate Receptor Binding Protein Localization To Cell Periphery Actin Filament-based Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Ruffle Extracellular Exosome
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