IFT25 and IFT27

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (affinity chromatography technology, biochemical)
HPRD (two hybrid)

		IFT25	IFT27
Description		intraflagellar transport 25	intraflagellar transport 27
Image			No pdb structure
GO Annotations	Cellular Component	Centrosome Cilium Intraciliary Transport Particle B Cell Projection Ciliary Tip	Golgi Membrane Nucleus Cytoplasm Golgi Apparatus Centrosome Cilium Intraciliary Transport Particle B Motile Cilium Sperm Flagellum Cell Projection Sperm Midpiece Sperm Principal Piece Ciliary Tip
	Molecular Function	Protein Binding Metal Ion Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding
	Biological Process	Skeletal System Development Kidney Development Smoothened Signaling Pathway Spermatogenesis Heart Development Protein Transport Cell Differentiation Lung Development Intraciliary Anterograde Transport Intraciliary Transport Cilium Assembly Left/right Axis Specification	Kidney Development Intracellular Protein Transport Smoothened Signaling Pathway Spermatogenesis Protein Transport Vesicle-mediated Transport Cell Differentiation Intraciliary Anterograde Transport Intraciliary Transport Inner Ear Receptor Cell Stereocilium Organization Cilium Assembly Cochlea Development
Pathways		Intraflagellar transport Intraflagellar transport	Intraflagellar transport Intraflagellar transport
Drugs
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS
Interacting Genes		5 interacting genes: GORASP2 IFT27 NUP62 SEC23IP TRAF3	3 interacting genes: GOLGA2 IFT25 TAB1
Entrez ID		51668	11020
HPRD ID		12730	11478
Ensembl ID		ENSG00000081870	ENSG00000100360
Uniprot IDs		Q9Y547 X6R7Y7	Q9BW83
PDB IDs		1TVG 1XPW
Enriched GO Terms of Interacting Partners?		Cellular Localization Intracellular Protein Transport Establishment Of Protein Localization Golgi Organization Organelle Assembly Toll Signaling Pathway Organelle Organization Endomembrane System Organization PTB Domain Binding Nuclear Pore Central Transport Channel Positive Regulation Of Mitotic Cytokinetic Process Positive Regulation Of Protein Localization To Centrosome Mitotic Centrosome Separation Protein Transport	Positive Regulation Of Protein Glycosylation Cellular Localization Protein Transport Establishment Of Protein Localization Establishment Of Localization In Cell Intracellular Transport Lung Development Regulation Of Protein Glycosylation Intracellular Protein Localization Golgi Disassembly Mitogen-activated Protein Kinase P38 Binding Positive Regulation Of CGAS/STING Signaling Pathway Importin-alpha Family Protein Binding Golgi Ribbon Formation Golgi Cis Cisterna Asymmetric Cell Division Kinase Activator Activity Left/right Axis Specification Meiotic Spindle Assembly Positive Regulation Of Glycoprotein Biosynthetic Process Intraciliary Transport Particle B Intraciliary Anterograde Transport Positive Regulation Of Glycoprotein Metabolic Process Meiotic Spindle Organization Coronary Vasculature Development Negative Regulation Of Protein Binding Microtubule Nucleation Organelle Assembly CGAS/STING Signaling Pathway Protein Exit From Endoplasmic Reticulum Non-canonical NF-kappaB Signal Transduction Aorta Development Regulation Of Glycoprotein Biosynthetic Process COPII-coated ER To Golgi Transport Vesicle Regulation Of Protein Binding Centrosome Cycle Cis-Golgi Network Mitotic Spindle Assembly Microtubule-based Process Artery Development Cardiac Septum Development Intraciliary Transport Ciliary Tip Syntaxin Binding Heart Morphogenesis Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction Protein Homotetramerization
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