NUB1 and UFD1

Number of citations of the paper that reports this interaction (PubMedID 24019527)
75

Data Source:
BioGRID (biochemical, pull down)

		NUB1	UFD1
Description		negative regulator of ubiquitin like proteins 1	ubiquitin recognition factor in ER associated degradation 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Lewy Body	Nucleus Nucleoplasm Cytoplasm Cytosol VCP-NPL4-UFD1 AAA ATPase Complex UFD1-NPL4 Complex
	Molecular Function	Protein Binding	Cysteine-type Deubiquitinase Activity Protein Binding Polyubiquitin Modification-dependent Protein Binding K48-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Type II Interferon Response To Tumor Necrosis Factor Proteolysis Involved In Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process	Skeletal System Development Ubiquitin-dependent Protein Catabolic Process Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Type I Interferon Production ERAD Pathway Negative Regulation Of RIG-I Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Misfolded Protein
Pathways			Translesion Synthesis by POLH Ub-specific processing proteases Neddylation KEAP1-NFE2L2 pathway Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs
Diseases
GWAS		Body fat mass ( 28552196) Carotid plaque burden ( 28282560) Eyebrow thickness ( 26926045)
Interacting Genes		12 interacting genes: AIPL1 COPB1 FANCA NEDD8 PSMD2 PSMD4 SF3B4 SNCAIP UBD UBE2K UFD1 VCP	23 interacting genes: A2M AMFR ANAPC2 CHMP2A F13A1 GZMK HSPB1 IGHM LRRK2 MAP3K1 MASP1 NGFR NPLOC4 NUB1 PIK3CA PPHLN1 SNX1 TAF1C TIAM2 TMUB1 TP53 UBC VCP
Entrez ID		51667	7353
HPRD ID		07450	06778
Ensembl ID		ENSG00000013374	ENSG00000070010
Uniprot IDs		H3BM14 H3BM74 Q9Y5A7	Q541A5 Q92890
PDB IDs		1WJU 8USB 8USC 8USD 9E8G 9E8H 9E8I 9E8J 9E8L 9E8N	2YUJ 5B6C 5C1B 7WWQ
Enriched GO Terms of Interacting Partners?		Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Polyubiquitin Modification-dependent Protein Binding Proteolysis Aggresome Assembly Proteasome Complex Nucleoplasm VCP-NPL4-UFD1 AAA ATPase Complex Inclusion Body Assembly K48-linked Polyubiquitin Modification-dependent Protein Binding Cytosol Cellular Response To Misfolded Protein Proteasome Regulatory Particle, Base Subcomplex Response To Misfolded Protein Ubiquitin Protein Ligase Binding Proteasome Accessory Complex Retrograde Protein Transport, ER To Cytosol Catabolic Process Macromolecule Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Topologically Incorrect Protein Protein Metabolic Process Protein Exit From Endoplasmic Reticulum Proteasomal Protein Catabolic Process Interstrand Cross-link Repair Protein Ubiquitination Protein Catabolic Process Flavin Adenine Dinucleotide Catabolic Process Farnesylated Protein Binding Protein Modification By Small Protein Conjugation Proteasome Storage Granule UFD1-NPL4 Complex VCP-NSFL1C Complex Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Positive Regulation Of Protein K63-linked Deubiquitination Nucleus Post-translational Protein Modification Regulation Of Protein Catabolic Process Regulation Of Proteolysis ERAD Pathway Cellular Response To Arsenite Ion Mitotic Spindle Disassembly Positive Regulation Of Oxidative Phosphorylation Protein Farnesylation Cytoplasm Protein Quality Control BAT3 Complex Binding Secretory Granule Lumen Endoplasmic Reticulum To Golgi Vesicle-mediated Transport	Proteolysis Involved In Protein Catabolic Process Proteolysis Ubiquitin Protein Ligase Binding Modification-dependent Protein Catabolic Process Intracellular Signaling Cassette BAT3 Complex Binding ERAD Pathway Intracellular Protein Transport Response To Endoplasmic Reticulum Stress Negative Regulation Of Macroautophagy Protein Metabolic Process Growth Cone Proteasomal Protein Catabolic Process Cytosol Macromolecule Catabolic Process Derlin-1 Retrotranslocation Complex Protein Transport VCP-NPL4-UFD1 AAA ATPase Complex Ubiquitin-dependent Protein Catabolic Process K48-linked Polyubiquitin Modification-dependent Protein Binding Catabolic Process Intracellular Transport Activation Of Membrane Attack Complex Protein Catabolic Process Negative Regulation Of Complement Activation Establishment Of Protein Localization Positive Regulation Of Protein Catabolic Process Regulation Of Immune Response Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Opsonization Retrograde Protein Transport, ER To Cytosol Macromolecule Metabolic Process Intracellular Protein Localization Ubiquitin-specific Protease Binding Symbiont Cell Surface Intracellular Signal Transduction Regulation Of Fibroblast Apoptotic Process Ubiquitin Binding Negative Regulation Of Autophagy Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Small GTPase-mediated Signal Transduction Regulation Of Complement Activation MAP Kinase Kinase Kinase Activity Extracellular Space Regulation Of Mitochondrion Organization Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Cellular Component Organization Positive Regulation Of Release Of Cytochrome C From Mitochondria Cellular Localization Blood Microparticle
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