PDK4 and DLAT

Number of citations of the paper that reports this interaction (PubMedID 11978179)
33

Data Source:
HPRD (in vitro)

		PDK4	DLAT
Description		pyruvate dehydrogenase kinase 4	dihydrolipoamide S-acetyltransferase
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Mitochondrion Mitochondrial Matrix Pyruvate Dehydrogenase Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity	Dihydrolipoyllysine-residue Acetyltransferase Activity Protein Binding Acetyltransferase Activity Transferase Activity Acyltransferase Activity Identical Protein Binding
	Biological Process	Regulation Of PH Insulin Receptor Signaling Pathway Cellular Response To Starvation Regulation Of Pyruvate Decarboxylation To Acetyl-CoA Regulation Of Ketone Metabolic Process Regulation Of Glucose Metabolic Process Cellular Response To Stress Regulation Of Fatty Acid Biosynthetic Process Glucose Homeostasis Response To Starvation Regulation Of Bone Resorption Regulation Of Fatty Acid Oxidation Cellular Response To Fatty Acid Reactive Oxygen Species Metabolic Process Negative Regulation Of Anoikis	Glucose Metabolic Process Pyruvate Decarboxylation To Acetyl-CoA Tricarboxylic Acid Cycle Pyruvate Catabolic Process
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid Protein lipoylation PDH complex synthesizes acetyl-CoA from PYR
Drugs		Tretinoin 4-[4-(4-methoxyphenyl)-5-methyl-1H-pyrazol-3-yl]benzene-1,3-diol	NADH Radicicol Dihydrolipoic Acid
Diseases			Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
GWAS		Refractive error ( 32231278)	Brain morphology (MOSTest) ( 32665545) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		5 interacting genes: DLAT PDHA1 PLEKHF2 REEP5 TRIM63	10 interacting genes: FOXP1 HMGB1 HUNK PDHA1 PDHX PDK1 PDK2 PDK3 PDK4 PRKD3
Entrez ID		5166	1737
HPRD ID		03957	10578
Ensembl ID		ENSG00000004799	ENSG00000150768
Uniprot IDs		A4D1H4 Q16654	A0A7P0T997 A0A7P0TAG1 A0A7P0TAX2 A0A7P0TBE2 A0A7P0TBK2 E9PEJ4 H0YDD4 P10515 Q86YI5
PDB IDs		2E0A 2ZDX 2ZDY 2ZKJ 3D2R 7EAT 7EBB 7EBG	1FYC 1Y8N 1Y8O 1Y8P 2DNE 2PNR 2Q8I 3B8K 3CRK 3CRL 6CT0 6H55 8PIU
Enriched GO Terms of Interacting Partners?		Pyruvate Decarboxylation To Acetyl-CoA Pyruvate Dehydrogenase Complex Acetyl-CoA Biosynthetic Process Acetyl-CoA Metabolic Process Tricarboxylic Acid Cycle Pyruvate Metabolic Process Acyl-CoA Metabolic Process Sulfur Compound Biosynthetic Process Dihydrolipoyllysine-residue Acetyltransferase Activity Glucose Metabolic Process Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Amide Biosynthetic Process Hexose Metabolic Process Pyruvate Dehydrogenase (acetyl-transferring) Activity Monosaccharide Metabolic Process Skeletal Muscle Atrophy Purine-containing Compound Biosynthetic Process Pyruvate Catabolic Process Sulfur Compound Metabolic Process Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, Disulfide As Acceptor Skeletal Muscle Adaptation Striated Muscle Atrophy Nucleoside Phosphate Biosynthetic Process Muscle Atrophy Titin Binding Contractile Muscle Fiber Endoplasmic Reticulum Membrane Organization Acetyltransferase Activity Mitochondrial Matrix Carbohydrate Metabolic Process Negative Regulation Of Glycolytic Process Endoplasmic Reticulum Tubular Network Monocarboxylic Acid Metabolic Process Purine-containing Compound Metabolic Process Catalytic Complex M Band Negative Regulation Of ATP Metabolic Process Organophosphate Biosynthetic Process Nucleoside Phosphate Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Sarcoplasmic Reticulum Membrane Response To Electrical Stimulus Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Muscle Hypertrophy	Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Pyruvate Dehydrogenase Complex Regulation Of Pyruvate Decarboxylation To Acetyl-CoA Regulation Of Acyl-CoA Biosynthetic Process Regulation Of Glucose Metabolic Process Mitochondrial Matrix Regulation Of Amide Metabolic Process Protein Kinase Activity Regulation Of Fatty Acid Metabolic Process Kinase Activity Regulation Of Small Molecule Metabolic Process Regulation Of Ketone Metabolic Process Hypoxia-inducible Factor-1alpha Signaling Pathway Pyruvate Decarboxylation To Acetyl-CoA Regulation Of Lipid Metabolic Process Acetyl-CoA Biosynthetic Process Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Glucose Metabolic Process ATP Binding Carbohydrate Metabolic Process Cellular Response To Stress Mitochondrion Hexose Metabolic Process Acetyl-CoA Metabolic Process Monosaccharide Metabolic Process Nucleotide Binding Transferase Activity T-helper Cell Differentiation Regulation Of Phosphorus Metabolic Process Cellular Response To Fatty Acid T Cell Differentiation Involved In Immune Response CD4-positive, Alpha-beta T Cell Differentiation Response To Fatty Acid Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of Myeloid Progenitor Cell Differentiation Macrophage Activation Regulation Of Interleukin-12 Production Alpha-beta T Cell Differentiation Pyruvate Metabolic Process T Cell Activation Involved In Immune Response Response To Lipid Insulin Receptor Signaling Pathway Cellular Response To Oxygen-containing Compound Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Negative Regulation Of Apoptotic Cell Clearance Dihydrolipoyllysine-residue Acetyltransferase Activity Positive Regulation Of Interleukin-21 Production Acyl-CoA Metabolic Process
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