PDGFRB and CDX1

		PDGFRB	CDX1
Description		platelet derived growth factor receptor beta	caudal type homeobox 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Golgi Apparatus Plasma Membrane Focal Adhesion Membrane Apical Plasma Membrane Cytoplasmic Vesicle Lysosomal Lumen Receptor Complex	Chromatin Nucleus
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Platelet Activating Factor Receptor Activity Platelet-derived Growth Factor Receptor Activity Platelet-derived Growth Factor Beta-receptor Activity GTPase Activator Activity Signaling Receptor Binding Platelet-derived Growth Factor Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Enzyme Binding Protein Kinase Binding Vascular Endothelial Growth Factor Binding Platelet-derived Growth Factor Binding Phospholipase C Activator Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Methyl-CpG Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Angiogenesis Chemotaxis Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Smooth Muscle Adaptation Positive Regulation Of Smooth Muscle Cell Migration Cell Migration Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Migration Regulation Of Actin Cytoskeleton Organization Cell Migration Involved In Vasculogenesis Platelet-derived Growth Factor Receptor-beta Signaling Pathway Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Aorta Morphogenesis Cellular Response To Platelet-derived Growth Factor Stimulus Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Positive Regulation Of Mitotic Nuclear Division Protein Autophosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Chemotaxis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cardiac Myofibril Assembly Cell Chemotaxis Cell Migration Involved In Coronary Angiogenesis Retina Vasculature Development In Camera-type Eye Positive Regulation Of ERK1 And ERK2 Cascade Smooth Muscle Cell Chemotaxis Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development Metanephric Glomerular Capillary Formation Positive Regulation Of Calcium Ion Import Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of DNA Biosynthetic Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Embryonic Pattern Specification Animal Organ Morphogenesis Anterior/posterior Axis Specification Anterior/posterior Pattern Specification Regulation Of Somitogenesis Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Bone Morphogenesis
Pathways		PIP3 activates AKT signaling Downstream signal transduction Signaling by PDGF Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs		Becaplermin Sorafenib Imatinib Dasatinib Sunitinib XL999 XL820 Pazopanib Midostaurin Regorafenib Nintedanib Polaprezinc Trapidil Foreskin fibroblast (neonatal) Tivozanib Fostamatinib Erdafitinib Pexidartinib Ripretinib Pralsetinib
Diseases		Glioma
GWAS		Blood protein levels ( 30072576) Cytokine network levels (multivariate analysis) ( 31679650) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory biomarkers (multivariate analysis) ( 33110245) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494)	Distal colorectal cancer ( 33632709) Distal/Left-sided colorectal cancer ( 33632709) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Rectal cancer ( 33632709)
Interacting Genes		86 interacting genes: ABL1 ABL2 ARAF BAG1 CAV1 CAV3 CBL CDK14 CDX1 CEP76 CHRM3 COPA COPB1 CRK EGFR EIF2AK2 ERBB2 FAXDC2 FGFR1 FYN GAB1 GRB10 GRB14 GRB2 GRB7 ITGB3 ITK JAK1 JAK2 KLHL12 KPRP KRT31 KRT34 KRTAP10-9 KRTAP12-3 KRTAP4-12 LCOR MITF NCK1 NCK2 NEDD4 NHERF1 NHERF2 PDAP1 PDGFB PDGFD PDGFRA PIK3C2B PIK3CA PIK3R1 PIK3R2 PIK3R3 PLAUR PLCG1 PPM1L PRDX2 PTEN PTK2 PTPN1 PTPN11 PTPN2 PTPN6 PTPRJ RAF1 RASA1 RPS6KB2 S1PR1 SHC1 SNX1 SNX2 SNX27 SNX4 SOCS1 SRC STAT1 STAT3 STAT5A STAT5B SYNGAP1 TNK2 TPTE TRIP6 TUFM TYK2 VAV1 YES1	4 interacting genes: CEBPA LEF1 PDGFRB SOX2
Entrez ID		5159	1044
HPRD ID		01423	02849
Ensembl ID		ENSG00000113721	ENSG00000113722
Uniprot IDs		P09619 Q59F04	P47902
PDB IDs		1GQ5 1H9O 1SHA 2IUI 2L6W 2PLD 2PLE 3MJG	5LUX 7Q3O
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Phosphotyrosine Residue Binding Regulation Of Cell Adhesion ERBB Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Cytosol Positive Regulation Of Cell Adhesion Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Protein Tyrosine Kinase Activity Regulation Of Signal Transduction Regulation Of MAPK Cascade Regulation Of Multicellular Organismal Process Intracellular Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Insulin Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Migration Growth Hormone Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Locomotion Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Migration Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation Regulation Of Programmed Cell Death Regulation Of Cell Motility Regulation Of Immune System Process Positive Regulation Of Cell Motility T Cell Activation Cell Activation Ephrin Receptor Binding Receptor Tyrosine Kinase Binding Positive Regulation Of Locomotion Positive Regulation Of T Cell Activation Cell Migration Response To Growth Factor Positive Regulation Of Multicellular Organismal Process Regulation Of Biological Quality	Transcription Regulator Complex Granulocyte Differentiation Transcription Cis-regulatory Region Binding Gland Development Regulation Of Cell Cycle DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Inner Ear Development Vasculature Development Sequence-specific DNA Binding Positive Regulation Of Biosynthetic Process Negative Regulation Of Developmental Process CHOP-C/EBP Complex Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Binding RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Regeneration Positive Regulation Of Cell Differentiation Response To Vitamin B2 Positive Regulation Of Macromolecule Biosynthetic Process Cell Population Proliferation C/EBP Complex RNA Polymerase II Transcription Regulator Complex Myeloid Leukocyte Differentiation Positive Regulation Of Metanephric Mesenchymal Cell Migration Cell Migration Involved In Coronary Angiogenesis Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development Smooth Muscle Cell Chemotaxis Phospholipase C Activator Activity Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Regulation Of Cell Cycle Process Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Glomerular Mesangial Cell Proliferation Metanephric Glomerular Capillary Formation Platelet-derived Growth Factor Beta-receptor Activity Platelet-derived Growth Factor Receptor Activity Platelet Activating Factor Receptor Activity Osteoblast Differentiation Regulation Of Myofibroblast Cell Apoptotic Process Sensory Organ Development Trachea Gland Development Negative Regulation Of Apoptotic Process In Bone Marrow Cell Chromatin White Fat Cell Proliferation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cell Migration Involved In Vasculogenesis Cell Chemotaxis Vascular Endothelial Growth Factor Binding
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