CDX1 and LEF1

Number of citations of the paper that reports this interaction (PubMedID 15143193)
64

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		CDX1	LEF1
Description		caudal type homeobox 1	lymphoid enhancer binding factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Protein-DNA Complex RNA Polymerase II Transcription Regulator Complex Beta-catenin-TCF Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Methyl-CpG Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding DNA Binding, Bending Nuclear Estrogen Receptor Binding Histone Deacetylase Binding Sequence-specific DNA Binding Gamma-catenin Binding Armadillo Repeat Domain Binding C2H2 Zinc Finger Domain Binding Transcription Regulator Inhibitor Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Embryonic Pattern Specification Animal Organ Morphogenesis Anterior/posterior Axis Specification Anterior/posterior Pattern Specification Regulation Of Somitogenesis Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Bone Morphogenesis	Negative Regulation Of Transcription By RNA Polymerase II Branching Involved In Blood Vessel Morphogenesis Osteoblast Differentiation Somitogenesis Epithelial To Mesenchymal Transition Vasculature Development Sprouting Angiogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Wnt Signaling Pathway Dentate Gyrus Development Hippocampus Development Forebrain Radial Glial Cell Differentiation Forebrain Neuroblast Division Formation Of Radial Glial Scaffolds Regulation Of Cell-cell Adhesion Regulation Of Wnt Signaling Pathway Cell Differentiation Positive Regulation Of Wnt Signaling Pathway Neutrophil Differentiation Embryonic Limb Morphogenesis Positive Regulation Of Cell Migration BMP Signaling Pathway Positive Regulation Of Granulocyte Differentiation Mammary Gland Development Negative Regulation Of Interleukin-13 Production Negative Regulation Of Interleukin-4 Production Negative Regulation Of Interleukin-5 Production T Cell Receptor V(D)J Recombination B Cell Proliferation Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Tongue Development Host-mediated Activation Of Viral Transcription T-helper 1 Cell Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Cell Differentiation Negative Regulation Of Striated Muscle Tissue Development Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Alpha-beta T Cell Differentiation Paraxial Mesoderm Formation Cell Development Regulation Of Neurogenesis Sensory Perception Of Taste Anatomical Structure Regression Canonical Wnt Signaling Pathway Face Morphogenesis Cell Chemotaxis Apoptotic Process Involved In Morphogenesis Chorio-allantoic Fusion Trachea Gland Development Secondary Palate Development Protein Localization To Chromatin Cellular Response To Cytokine Stimulus Cellular Response To Interleukin-4 Positive Regulation Of Cell Proliferation In Bone Marrow Negative Regulation Of Apoptotic Process In Bone Marrow Cell Positive Regulation Of Cell Cycle Process Positive Regulation Of Odontoblast Differentiation Apoptotic Process Involved In Blood Vessel Morphogenesis Positive Regulation Of Chondrocyte Proliferation Epithelial Cell Apoptotic Process Positive Regulation Of Endothelial Cell-matrix Adhesion Via Fibronectin
Pathways			Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex Ca2+ pathway Binding of TCF/LEF:CTNNB1 to target gene promoters Repression of WNT target genes Repression of WNT target genes Transcriptional Regulation by VENTX RUNX3 regulates WNT signaling Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis Cardiogenesis Germ layer formation at gastrulation Formation of paraxial mesoderm Formation of axial mesoderm Somitogenesis Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in cell cycle and proliferation Transcriptional and post-translational regulation of MITF-M expression and activity Regulation of PD-L1(CD274) transcription
Drugs			Etacrynic acid
Diseases
GWAS		Distal colorectal cancer ( 33632709) Distal/Left-sided colorectal cancer ( 33632709) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Rectal cancer ( 33632709)	Airflow obstruction ( 22837378) Blond vs. brown/black hair color ( 30531825) Chronic lymphocytic leukemia ( 23770605 26956414 28165464) Diastolic blood pressure ( 27841878) Medication use (calcium channel blockers) ( 31015401) Metabolic traits ( 19060910) Multiple sclerosis ( 31604244) Systemic lupus erythematosus ( 22291604) Systolic blood pressure ( 27841878 30578418) Tooth agenesis (mandibular second premolars) ( 29364747)
Interacting Genes		4 interacting genes: CEBPA LEF1 PDGFRB SOX2	35 interacting genes: ALX4 ALYREF AURKA BAX BUB1 CDX1 CTNNB1 DPYSL2 EP300 KPNA1 KPNA2 MITF MLH1 MLH3 MSH2 NFE2L2 NLK NOTCH1 NRAS PIAS4 PITX2 RAP1GDS1 RB1 RUNX2 SMAD1 SMAD2 SMAD3 SMAD4 STK11 SUMO2 TLE1 TLE2 TRA UBTF ZBTB3
Entrez ID		1044	51176
HPRD ID		02849	01075
Ensembl ID		ENSG00000113722	ENSG00000138795
Uniprot IDs		P47902	Q9UJU2
PDB IDs		5LUX 7Q3O
Enriched GO Terms of Interacting Partners?		Transcription Regulator Complex Granulocyte Differentiation Transcription Cis-regulatory Region Binding Gland Development Regulation Of Cell Cycle DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Inner Ear Development Vasculature Development Sequence-specific DNA Binding Positive Regulation Of Biosynthetic Process Negative Regulation Of Developmental Process CHOP-C/EBP Complex Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Binding RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Regeneration Positive Regulation Of Cell Differentiation Response To Vitamin B2 Positive Regulation Of Macromolecule Biosynthetic Process Cell Population Proliferation C/EBP Complex RNA Polymerase II Transcription Regulator Complex Myeloid Leukocyte Differentiation Positive Regulation Of Metanephric Mesenchymal Cell Migration Cell Migration Involved In Coronary Angiogenesis Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development Smooth Muscle Cell Chemotaxis Phospholipase C Activator Activity Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Regulation Of Cell Cycle Process Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Glomerular Mesangial Cell Proliferation Metanephric Glomerular Capillary Formation Platelet-derived Growth Factor Beta-receptor Activity Platelet-derived Growth Factor Receptor Activity Platelet Activating Factor Receptor Activity Osteoblast Differentiation Regulation Of Myofibroblast Cell Apoptotic Process Sensory Organ Development Trachea Gland Development Negative Regulation Of Apoptotic Process In Bone Marrow Cell Chromatin White Fat Cell Proliferation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cell Migration Involved In Vasculogenesis Cell Chemotaxis Vascular Endothelial Growth Factor Binding	Transcription Regulator Complex Nucleoplasm Chromatin Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Binding Positive Regulation Of Macromolecule Metabolic Process I-SMAD Binding Axis Specification Animal Organ Morphogenesis Pattern Specification Process Ubiquitin Protein Ligase Binding Regulation Of Primary Metabolic Process Tube Development SMAD Protein Complex Positive Regulation Of Metabolic Process Heteromeric SMAD Protein Complex Signal Transduction SMAD Protein Signal Transduction Positive Regulation Of RNA Metabolic Process Cell Fate Commitment Embryonic Pattern Specification Regionalization RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Anatomical Structure Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Cell Population Proliferation Regulation Of Wnt Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Developmental Process Positive Regulation Of Biosynthetic Process Regulation Of Canonical Wnt Signaling Pathway Anterior/posterior Pattern Specification Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Wnt Signaling Pathway Developmental Growth Regulation Of Metabolic Process Wnt Signaling Pathway Intracellular Signaling Cassette Cell Surface Receptor Signaling Pathway Regulation Of Gene Expression Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
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