PDE6B and GLA

		PDE6B	GLA
Description		phosphodiesterase 6B	galactosidase alpha
Image		No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Plasma Membrane Membrane Photoreceptor Outer Segment Membrane Cell Projection Photoreceptor Disc Membrane	Extracellular Region Cytoplasm Lysosome Golgi Apparatus Membrane Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Phosphoric Diester Hydrolase Activity Hydrolase Activity Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity	Catalytic Activity Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Alpha-galactosidase Activity Signaling Receptor Binding Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Protein Homodimerization Activity
	Biological Process	Signal Transduction Visual Perception Phototransduction, Visible Light Detection Of Light Stimulus Entrainment Of Circadian Clock By Photoperiod Retina Development In Camera-type Eye Negative Regulation Of CAMP/PKA Signal Transduction Retinal Cell Apoptotic Process	Carbohydrate Metabolic Process Lipid Metabolic Process Oligosaccharide Metabolic Process Glycoside Catabolic Process Negative Regulation Of Nitric Oxide Biosynthetic Process Glycosylceramide Catabolic Process Glycosphingolipid Catabolic Process Negative Regulation Of Nitric-oxide Synthase Activity
Pathways		Activation of the phototransduction cascade Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Ca2+ pathway Ca2+ pathway	Neutrophil degranulation Glycosphingolipid catabolism
Drugs		Caffeine Trapidil	Migalastat
Diseases		Congenital stationary night blindness (CSNB), including: CSNB type 1 (CSNB1); CSNB type 2 (CSNB2); CSNB autosomal dominant (CSNBAD); Oguchi disease/ CSNB Oguchi type (CSNBO) Retinitis pigmentosa (RP)	Fabry disease
GWAS
Interacting Genes		2 interacting genes: GLA THTPA	15 interacting genes: ANKRD30A CCR2 COL4A5 DUSP6 GPR17 GUCY2F HNRNPH2 MORF4L2 NAP1L3 NOSTRIN OGT PDE6B PLP1 TERT UBC
Entrez ID		5158	2717
HPRD ID		01571	02357
Ensembl ID		ENSG00000133256	ENSG00000102393
Uniprot IDs		B4DHV7 P35913	A0A3B3IUC4 A0A6Q8PHD1 P06280 Q53Y83
PDB IDs			1R46 1R47 3GXN 3GXP 3GXT 3HG2 3HG3 3HG4 3HG5 3LX9 3LXA 3LXB 3LXC 3S5Y 3S5Z 3TV8 4NXS 6IBK 6IBM 6IBR 6IBT 8K7D 8K7E 8K7F 8K7G 8K7H 8K7I 8K7J 8K7K 8K7L 9AVS
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nitric-oxide Synthase Activity Alpha-galactosidase Activity Thiamine Triphosphate Phosphatase Activity Thiamine Diphosphate Metabolic Process Thiamine Diphosphate Biosynthetic Process Thiamine Metabolic Process Glycosylceramide Catabolic Process Regulation Of Nitric-oxide Synthase Activity Glycoside Catabolic Process Negative Regulation Of Oxidoreductase Activity Thiamine-containing Compound Metabolic Process Glycosylceramide Metabolic Process Glycosphingolipid Catabolic Process Ceramide Catabolic Process Negative Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Oxidoreductase Activity Glycolipid Catabolic Process Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Vitamin Metabolic Process Sphingolipid Catabolic Process Pyrimidine-containing Compound Biosynthetic Process Membrane Lipid Catabolic Process Glycosphingolipid Metabolic Process Oligosaccharide Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Hydrolase Activity, Acting On Glycosyl Bonds Pyrimidine-containing Compound Metabolic Process Hydrolase Activity Glycolipid Metabolic Process Ceramide Metabolic Process Azurophil Granule Lumen Lysosomal Lumen Sulfur Compound Biosynthetic Process Dephosphorylation Sphingolipid Metabolic Process Negative Regulation Of Catalytic Activity Carbohydrate Derivative Catabolic Process Membrane Lipid Metabolic Process Magnesium Ion Binding
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