GDE1 and CLGN

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		GDE1	CLGN
Description		glycerophosphodiester phosphodiesterase 1	calmegin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle	Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Phosphatidylcholine Lysophospholipase Activity Protein Binding Phosphoric Diester Hydrolase Activity Glycerophosphodiester Phosphodiesterase Activity Hydrolase Activity Metal Ion Binding Glycerophosphoinositol Glycerophosphodiesterase Activity	Calcium Ion Binding Protein Folding Chaperone Unfolded Protein Binding
	Biological Process	Ethanolamine Metabolic Process Lipid Metabolic Process Phospholipid Metabolic Process Glycerophospholipid Catabolic Process N-acylethanolamine Metabolic Process	Protein Folding Single Fertilization Binding Of Sperm To Zona Pellucida ERAD Pathway Protein-containing Complex Assembly
Pathways		Glycerophospholipid catabolism
Drugs
Diseases
GWAS			Diastolic blood pressure x sodium interaction (2df test) ( 27271309) Malaria ( 31844061) Mean arterial pressure x sodium interaction (2df test) ( 27271309) Select biomarker traits ( 17903293) Systolic blood pressure x sodium interaction (2df test) ( 27271309) Triglyceride levels in HIV infection ( 33109212)
Interacting Genes		7 interacting genes: ADRA1A CLGN RGS1 RGS16 RGS19 RGS2 SLC10A1	4 interacting genes: ADAM2 GDE1 LINC00839 XK
Entrez ID		51573	1047
HPRD ID		12070	03513
Ensembl ID		ENSG00000006007	ENSG00000153132
Uniprot IDs		Q9NZC3	A0A140VKG2 O14967
PDB IDs
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cardiac Muscle Contraction GTPase Activity Positive Regulation Of Striated Muscle Contraction G-protein Alpha-subunit Binding Calmodulin Binding Positive Regulation Of Heart Contraction GTPase Activator Activity Positive Regulation Of Muscle Contraction Regulation Of Smooth Muscle Contraction Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Regulation Of Cardiac Muscle Hypertrophy Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Regulation Of Cardiac Muscle Contraction Positive Regulation Of GTPase Activity Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Phospholipase C-activating Adrenergic Receptor Signaling Pathway Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Striated Muscle Contraction Cytoplasmic Side Of Plasma Membrane Negative Regulation Of Glycine Import Across Plasma Membrane Positive Regulation Of Hydrolase Activity Response To Ethanol Pilomotor Reflex Alpha1-adrenergic Receptor Activity Positive Regulation Of The Force Of Heart Contraction By Chemical Signal Negative Regulation Of Signal Transduction Regulation Of GTPase Activity Membrane Leukotriene Signaling Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase Inhibitor Activity Plasma Membrane Regulation Of Muscle Contraction Neuron-glial Cell Signaling Bile Acid:sodium Symporter Activity Regulation Of The Force Of Heart Contraction By Chemical Signal Relaxation Of Vascular Associated Smooth Muscle Regulation Of Signal Transduction Regulation Of Heart Contraction Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Relaxation Of Smooth Muscle Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Action Potential Adrenergic Receptor Activity Bile Acid Transmembrane Transporter Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway	Ethanolamine Metabolic Process Glycerophosphoinositol Glycerophosphodiesterase Activity Intracellular Magnesium Ion Homeostasis Regulation Of Axon Diameter N-acylethanolamine Metabolic Process Glycerophosphodiester Phosphodiesterase Activity Regulation Of Cell Projection Size Magnesium Ion Homeostasis
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