ANAPC5 and BACH1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ANAPC5	BACH1
Description		anaphase promoting complex subunit 5	BTB domain and CNC homolog 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Anaphase-promoting Complex Cytoplasm Spindle Cytosol Cytoskeleton	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Protein Phosphatase Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Heme Binding Ligand-modulated Transcription Factor Activity
	Biological Process	Regulation Of Mitotic Cell Cycle Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Regulation Of Meiotic Cell Cycle Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Branched Polyubiquitination	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation	Regulation of HMOX1 expression and activity Heme signaling Regulation of BACH1 activity NFE2L2 regulating anti-oxidant/detoxification enzymes
Drugs
Diseases
GWAS			Alanine aminotransferase levels ( 33547301) Aspartate aminotransferase levels ( 33547301) Creatine kinase levels ( 29403010) Haemorrhoidal disease ( 33888516) Pancreatic cancer ( 22158540) Selective IgA deficiency ( 27723758) Visceral fat ( 22589738)
Interacting Genes		11 interacting genes: BACH1 CREBBP ID2 MAPK6 PABPC1 SBNO1 SMURF1 SMURF2 TGFBR1 UBE2S ZBTB16	19 interacting genes: ANAPC5 ATF2 BATF2 BRCC3 CFTR DDIT3 DYNLL1 HLCS HMMR KIF5A MAFB MAFK NR1D1 PATZ1 RBCK1 RPS27A TCF4 USP7 WAC
Entrez ID		51433	571
HPRD ID		10453	04127
Ensembl ID		ENSG00000089053	ENSG00000156273
Uniprot IDs		F5H0F9 Q9UJX4	O14867
PDB IDs		4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5 6TNT 8PKP 8TAR 8TAU 9GAW	2IHC 8S7D 8UA3 8UA6 8UAH 8UBT 8UBU 8UBV 9GP5 9GR9 9GRA
Enriched GO Terms of Interacting Partners?		SMAD Binding Regulation Of Primary Metabolic Process Protein Modification Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway I-SMAD Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Post-translational Protein Modification Embryonic Morphogenesis Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Developmental Process Kidney Development Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Neuron Fate Commitment Transferase Activity Macromolecule Metabolic Process Nucleus Positive Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Protein Ubiquitination Non-canonical Wnt Signaling Pathway Regulation Of Chondrocyte Differentiation Ubiquitin-protein Transferase Activity Embryonic Digit Morphogenesis Wnt Signaling Pathway Nucleoplasm Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Conjugation Engulfment Of Target By Autophagosome Protein Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cytosol Positive Regulation Of Fat Cell Differentiation Negative Regulation Of BMP Signaling Pathway Regulation Of Cartilage Development Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of Cellular Response To Growth Factor Stimulus Histone H3K27 Acetyltransferase Activity Septin Cytoskeleton Vascular Endothelial Cell Proliferation Epicardium Morphogenesis	RNA Polymerase II Transcription Regulator Complex RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Chromatin Integrated Stress Response Signaling Cellular Response To Stress Regulation Of Nucleobase-containing Compound Metabolic Process Proteolysis Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of DNA-binding Transcription Factor Activity CAMP Response Element Binding Protein Binding Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Leucine Zipper Domain Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Response To Nutrient Levels DNA Damage Response Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Biosynthetic Process DNA Damage Checkpoint Signaling Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Post-translational Protein Modification Nucleus Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Intracellular Signal Transduction Mononuclear Cell Differentiation Positive Regulation Of RNA Metabolic Process Protein Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II T Cell Differentiation Signal Transduction In Response To DNA Damage Macromolecule Catabolic Process Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Leukocyte Differentiation Proteolysis Involved In Protein Catabolic Process Response To Stress Regulation Of Insulin Secretion Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Abducens Nucleus Development Hypoglossal Nucleus Development DNA Binding Intrinsic Apoptotic Signaling Pathway In Response To Nitrosative Stress
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