DDX41 and CHAF1A

Number of citations of the paper that reports this interaction (PubMedID 21209461)
64

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		DDX41	CHAF1A
Description		DEAD-box helicase 41	chromatin assembly factor 1 subunit A
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Endoplasmic Reticulum Cytosol Membrane Catalytic Step 2 Spliceosome	Chromatin Nucleus Protein-containing Complex CAF-1 Complex
	Molecular Function	Nucleotide Binding Nucleic Acid Binding DNA Binding RNA Binding RNA Helicase Activity MRNA Binding Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Metal Ion Binding	Chromatin Binding Protein Binding Identical Protein Binding Unfolded Protein Binding Chromo Shadow Domain Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing Apoptotic Process Cell Population Proliferation RNA Splicing Cell Differentiation Positive Regulation Of Type I Interferon Production Cellular Response To Interferon-beta Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus CGAS/STING Signaling Pathway	DNA Replication DNA Repair Chromatin Organization Nucleosome Assembly DNA Replication-dependent Chromatin Assembly DNA Damage Response
Pathways		STING mediated induction of host immune responses Regulation of innate immune responses to cytosolic DNA IRF3-mediated induction of type I IFN mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Hemoglobin ( 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 27863252 28957414 32888494)
Interacting Genes		11 interacting genes: AIDA CEBPA CEP70 CHAF1A KLC2 NKAPL OGT SIAH1 TRIM26 TRIM41 TUBG1	47 interacting genes: ANP32A ANP32B ASF1A ASF1B BLM CBX1 CBX5 CDC7 CDK2 CHAF1B CREBBP DBF4 DDX41 H3-4 H3C6 HMGB2 LZTR1 MBD1 MEI4 MSH6 NOTO PABPC1 PAX6 PCBD2 PCNA POU6F2 RBFOX2 REL SERTAD1 SET SPOP STAT5B SUMO1 SUMO2 SUMO3 TCERG1 TCF4 TRIB3 TRIM28 XRCC5 XRCC6 YWHAB YWHAE YWHAG YWHAQ ZNF408 ZNF620
Entrez ID		51428	10036
HPRD ID		10490	03148
Ensembl ID		ENSG00000183258	ENSG00000167670
Uniprot IDs		B3KRK2 Q9UJV9	Q13111
PDB IDs		2P6N 5GVR 5GVS 5H1Y 8C6J	7Y5K 7Y5L 7Y5O 7Y5U 7Y5V 7Y60 7Y61 8IQF 8IQG 8J6S 8J6T
Enriched GO Terms of Interacting Partners?			Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Nucleoplasm Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Chromatin Organization DNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Remodeling Nucleic Acid Metabolic Process Nucleosome Assembly DNA Repair Regulation Of Metabolic Process Regulation Of Gene Expression DNA Damage Response Negative Regulation Of RNA Metabolic Process DNA Replication-dependent Chromatin Assembly Protein-DNA Complex Assembly Regulation Of Macromolecule Biosynthetic Process Nucleosome Organization Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin DNA Recombination Regulation Of Transcription By RNA Polymerase II Chromosome, Telomeric Region Damaged DNA Binding Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Chromatin Binding Cellular Response To Stress Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein-containing Complex Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process DNA Binding Chromosome Organization Positive Regulation Of Macromolecule Metabolic Process Macromolecule Metabolic Process Telomere Organization ATP-dependent Activity, Acting On DNA Ubiquitin Protein Ligase Binding Chromosome Positive Regulation Of Metabolic Process Recombinational Repair Double-strand Break Repair
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