BIN2 and FAM3B

		BIN2	FAM3B
Description		bridging integrator 2	FAM3 metabolism regulating signaling molecule B
Image			No pdb structure
GO Annotations	Cellular Component	Phagocytic Cup Podosome Extracellular Region Cytoplasm Plasma Membrane Cell Cortex Membrane Secretory Granule Lumen Cell Projection Anchoring Junction Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space Extracellular Exosome
	Molecular Function	Protein Binding Phospholipid Binding	Cytokine Activity Protein Binding Carbohydrate Binding
	Biological Process	Phagocytosis, Engulfment Cell Chemotaxis Podosome Assembly Plasma Membrane Tubulation	Apoptotic Process Signal Transduction Insulin Secretion
Pathways		Neutrophil degranulation Signaling by membrane-tethered fusions of PDGFRA or PDGFRB
Drugs
Diseases
GWAS		Aging (time to death) ( 21782286) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Mean platelet volume ( 27863252 32888494) Platelet count ( 32888494)	Blood protein levels ( 30072576) Elevated serum carcinoembryonic antigen levels ( 24941225) Glycemic traits (pregnancy) ( 23903356) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) Tumor biomarkers ( 23300138)
Interacting Genes		6 interacting genes: APPBP2 CEBPA FAM3B POT1 TERF1 TINF2	7 interacting genes: APP BIN2 COL6A1 FCGR2A H2BC12L KCNAB2 MAP3K7CL
Entrez ID		51411	54097
HPRD ID		05805	10552
Ensembl ID		ENSG00000110934	ENSG00000183844
Uniprot IDs		Q9UBW5	P58499
PDB IDs		4AVM 4I1Q
Enriched GO Terms of Interacting Partners?		Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Assembly Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Telomeric D-loop Disassembly Telomere Maintenance Positive Regulation Of Chromosome Organization G-rich Strand Telomeric DNA Binding Regulation Of Telomere Maintenance Telomeric Loop Disassembly Telomere Organization Negative Regulation Of DNA Metabolic Process Chromosome, Telomeric Region Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Regulation Of Chromosome Organization Positive Regulation Of DNA Metabolic Process Chromosome Organization RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding DNA Biosynthetic Process Regulation Of DNA Metabolic Process Positive Regulation Of Organelle Organization Response To Vitamin B2 C/EBP Complex Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Telomeric Loop Disassembly Perinucleolar Chromocenter Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Matrix CHOP-C/EBP Complex 8-hydroxy-2'-deoxyguanosine DNA Binding	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Regulation Of Response To Calcium Ion Positive Regulation Of Tumor Necrosis Factor Production Amylin Binding Endosome To Plasma Membrane Transport Vesicle Antibacterial Humoral Response Protein Tetramerization Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Defense Response To Gram-positive Bacterium Defense Response Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Locomotion Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Collagen Type VI Trimer Multicellular Organismal Locomotion Response To Polyamine Macromolecule Pinceau Fiber Methylglyoxal Reductase (NADPH) (acetol Producing) Activity Regulation Of Spontaneous Synaptic Transmission Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Regulation Of Tumor Necrosis Factor Production NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Endocytosis Cellular Response To Norepinephrine Stimulus Regulation Of Toll Signaling Pathway Growth Factor Receptor Binding Main Axon Antimicrobial Humoral Response Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Response To Bleomycin Apoptotic Nuclear Changes Skeletal Muscle Tissue Growth
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