CDC40 and MIRLET7E

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		CDC40	MIRLET7E
Description		cell division cycle 40	microRNA let-7e
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome	Extracellular Space RISC Complex
	Molecular Function	RNA Binding MRNA Binding Protein Binding	MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Embryonic Brain Development	MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Interleukin-6-mediated Signaling Pathway Negative Regulation Of Receptor Signaling Pathway Via STAT Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS		Daytime sleep phenotypes ( 27126917)
Interacting Genes		10 interacting genes: CRYAA DHX38 EPS15 MIR106B MIRLET7A2 MIRLET7E MIRLET7G SMAD2 SMURF1 TUBE1	105 interacting genes: AIMP1 AIMP2 APOBEC3B AQR ATXN2L C1QBP CDC40 CDC5L CELF1 CHERP CPSF1 CRTAP DARS1 DDX1 DDX21 DDX23 DDX3X DHX36 DHX37 EDC4 EIF2AK2 EPRS1 ERAL1 FAM98A FAM98B FUS G3BP2 GRSF1 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI2 MYEF2 NOL6 NONO NUDT16L1 NUDT21 NUFIP2 PDCD11 PGAM5 PLOD1 PLRG1 PRMT1 PTBP1 PUF60 PUM1 PUM2 PURA QARS1 RARS1 RBFOX2 RBM10 RBM14 RBM4 RBM47 RBM5 RTCB SART3 SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SUGP2 SYMPK SYNCRIP TAF15 TRA2A TRA2B TUT7 U2SURP UPF1 UTP20 XAB2 YBX1 YBX2 YBX3 ZFR ZNF346
Entrez ID		51362	406887
HPRD ID		05721
Ensembl ID		ENSG00000168438	ENSG00000198972
Uniprot IDs		O60508
PDB IDs		5MQF 5XJC 5YZG 5Z56 5Z57 6FF4 6FF7 6ICZ 6ID0 6ID1 6QDV 6ZYM 7A5P 7AAV 7ABI 7W59 7W5A 7W5B 8C6J 8CH6 8I0T 8I0U 8I0V 8I0W 8RO2 9FMD
Enriched GO Terms of Interacting Partners?		RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Negative Regulation Of Gene Expression Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Transforming Growth Factor Beta Receptor Binding I-SMAD Binding Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway R-SMAD Binding Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell MiRNA-mediated Gene Silencing By MRNA Destabilization Post-transcriptional Regulation Of Gene Expression SMAD Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Engulfment Of Target By Autophagosome Negative Regulation Of Biosynthetic Process Regulation Of Cellular Response To Growth Factor Stimulus Homomeric SMAD Protein Complex Negative Regulation Of Macromolecule Metabolic Process MRNA Destabilization Zygotic Specification Of Dorsal/ventral Axis Activin Responsive Factor Complex Paraxial Mesoderm Morphogenesis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway RNA Destabilization Regulation Of BMP Signaling Pathway Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Metabolic Process Response To Glucose Embryonic Organ Morphogenesis Regulation Of Macromolecule Metabolic Process Response To Monosaccharide Mesoderm Morphogenesis Positive Regulation Of Cell Growth Lens Fiber Cell Morphogenesis Ubiquitin-dependent Endocytosis Clathrin Coat Of Coated Pit Response To Carbohydrate Odontoblast Differentiation SMAD Protein Complex Pericardium Development Trophoblast Cell Migration 3'-5' RNA Helicase Activity Activin Receptor Binding Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Catabolic Process	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process RNA Splicing Nucleic Acid Metabolic Process MRNA Metabolic Process MRNA Processing Nucleobase-containing Compound Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Binding Regulation Of MRNA Metabolic Process Macromolecule Metabolic Process Spliceosomal Complex Catalytic Step 2 Spliceosome Regulation Of RNA Splicing Nucleoplasm Nucleus Post-transcriptional Regulation Of Gene Expression Aminoacyl-tRNA Synthetase Multienzyme Complex MiRNA Binding Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Cytoplasmic Stress Granule Negative Regulation Of MRNA Metabolic Process Ribonucleoprotein Complex MRNA 3'-UTR Binding Regulation Of Translation Regulation Of RNA Stability Regulation Of MRNA Stability Negative Regulation Of RNA Catabolic Process Negative Regulation Of MRNA Catabolic Process RNA Stabilization MRNA Stabilization Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translation Protein-RNA Complex Assembly Regulation Of Macromolecule Metabolic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Positive Regulation Of Gene Expression TRNA Aminoacylation TRNA Metabolic Process U2 SnRNP Regulation Of Primary Metabolic Process Spliceosomal Complex Assembly Positive Regulation Of Cytoplasmic Translation
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