HOOK1 and UTP14C

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HOOK1	UTP14C
Description		hook microtubule tethering protein 1	UTP14C small subunit processome component
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytoskeleton Microtubule Microtubule Cytoskeleton HOPS Complex FHF Complex	Nucleus Nucleolus Cytosol Small-subunit Processome
	Molecular Function	Actin Binding Protein Binding Microtubule Binding Identical Protein Binding Protein Homodimerization Activity Dynein Light Intermediate Chain Binding	Protein Binding
	Biological Process	Golgi Organization Endosome Organization Lysosome Organization Spermatogenesis Spermatid Development Endosome To Lysosome Transport Protein Transport Cell Differentiation Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Early Endosome To Late Endosome Transport Manchette Assembly Protein Localization To Perinuclear Region Of Cytoplasm	RRNA Processing Spermatogenesis Cell Differentiation Ribosome Biogenesis Meiotic Cell Cycle
Pathways			rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917)
Interacting Genes		50 interacting genes: AKTIP ANK3 ANKRD23 AP1M1 AP4M1 CCDC9 CDC5L CDK4 CUL1 CWF19L2 DENND1B ERI3 ESS2 EXOSC7 FAM161A FHIP1B HNRNPLL HOOK2 HOOK3 KAT5 LENG1 LMO2 MEOX2 MRPL37 MYSM1 PIAS2 PRPF6 RBM22 RNF10 RPS7 S100A7 SNW1 TBC1D7 TFIP11 UNKL USP2 UTP14A UTP14C VPS16 VPS18 VPS39 VPS41 ZBTB47 ZNF250 ZNF35 ZNF572 ZNF655 ZNF764 ZNF785 ZNF80	34 interacting genes: ALAS1 BICD2 C8orf34 CARD10 CCDC57 CEP70 GCC1 GOLGA2 GOLGA6A HOOK1 HOOK2 JRK KANK2 KRT34 KRT40 LZTS2 MCC MEOX2 MTUS2 NAB2 NUDT15 PDE4DIP PIBF1 PRICKLE1 RABEP1 RINT1 RNF10 TEX11 TRAF1 TRAF2 TRIM27 TRIM54 TXLNA USP7
Entrez ID		51361	9724
HPRD ID		07428	12346
Ensembl ID		ENSG00000134709	ENSG00000253797
Uniprot IDs		Q9UJC3	Q5TAP6
PDB IDs
Enriched GO Terms of Interacting Partners?		HOPS Complex Endosome To Lysosome Transport Vacuolar Transport Lysosomal Transport FHF Complex Protein Localization To Perinuclear Region Of Cytoplasm Lysosome Organization Vacuole Organization Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion Catalytic Step 2 Spliceosome Vesicle Organization Early Endosome To Late Endosome Transport MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Clathrin-coated Vesicle AP-3 Adaptor Complex Endosome Organization RNA Processing Regulation Of Transcription By RNA Polymerase II Lysosomal HOPS Complex Protein Transport Endosomal Transport Spliceosomal Complex MRNA Processing Establishment Of Protein Localization MRNA Metabolic Process Zinc Ion Binding RNA Splicing U2-type Catalytic Step 2 Spliceosome Vesicle-mediated Transport Nucleus Intracellular Transport Regulation Of Macromolecule Metabolic Process RNA Metabolic Process CORVET Complex Regulation Of Gene Expression Vesicle Fusion Regulation Of Metabolic Process Nuclear Speck Organelle Membrane Fusion Regulation Of DNA-templated Transcription Positive Regulation Of RNA Splicing Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Cellular Localization Regulation Of Primary Metabolic Process Nucleic Acid Metabolic Process Protein Targeting To Vacuole Clathrin Adaptor Complex	Microtubule Cytoskeleton Organization Cytoskeleton Organization Cytoskeleton Microtubule-based Process Centrosome Dynein Light Intermediate Chain Binding Cytoplasm Organelle Organization FHF Complex Microtubule Mitotic Spindle Assembly Protein Localization To Perinuclear Region Of Cytoplasm Microtubule Binding Thioesterase Binding Golgi Cis Cisterna Spindle Organization Cytoplasmic Microtubule Organization Regulation Of Microtubule Cytoskeleton Organization Vesicle-mediated Transport HOPS Complex Supramolecular Fiber Organization Cellular Component Assembly Regulation Of Cytoskeleton Organization Cytoskeleton-dependent Intracellular Transport Microtubule Organizing Center Organization Positive Regulation Of Protein Modification Process Mitotic Spindle Organization Spindle Assembly Microtubule Organizing Center Early Endosome To Late Endosome Transport Negative Regulation Of Autophagy Golgi Organization Microtubule Nucleation Intracellular Transport Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Organelle Organization Tumor Necrosis Factor Receptor Binding TORC2 Complex Disassembly Regulation Of Microtubule-based Process Cilium Assembly Meiotic Gene Conversion Primary Ureteric Bud Growth Anterior Visceral Endoderm Cell Migration Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation Polarized Secretion Of Basement Membrane Proteins In Epithelium Cell Trailing Edge Membraneless Organelle Assembly Golgi Vesicle Transport Microtubule Cytoskeleton Organization Involved In Mitosis
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