MBTPS2 and ATF6B

Number of citations of the paper that reports this interaction (PubMedID 11163209)
0

Data Source:
HPRD (in vivo)

		MBTPS2	ATF6B
Description		membrane bound transcription factor peptidase, site 2	activating transcription factor 6 beta
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Membrane	Golgi Membrane Chromatin Nucleus Nucleoplasm Nucleolus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Protein-DNA Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Metalloendopeptidase Activity Peptidase Activity Metallopeptidase Activity Hydrolase Activity Metal Ion Binding Transcription Regulator Activator Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Proteolysis NLS-bearing Protein Import Into Nucleus Lipid Metabolic Process Mitotic G2 DNA Damage Checkpoint Signaling Steroid Metabolic Process Cholesterol Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Membrane Protein Intracellular Domain Proteolysis Response To Endoplasmic Reticulum Stress ATF6-mediated Unfolded Protein Response Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Protein Maturation Bone Maturation Regulation Of Response To Endoplasmic Reticulum Stress	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Response To Unfolded Protein Signal Transduction Endoplasmic Reticulum Unfolded Protein Response Response To Endoplasmic Reticulum Stress ATF6-mediated Unfolded Protein Response Positive Regulation Of Transcription By RNA Polymerase II Regulation Of ATF6-mediated Unfolded Protein Response Negative Regulation Of ATF6-mediated Unfolded Protein Response
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) ATF6 (ATF6-alpha) activates chaperones ATF6B (ATF6-beta) activates chaperones CREB3 factors activate genes CREB3 factors activate genes Assembly of active LPL and LIPC lipase complexes	ATF6B (ATF6-beta) activates chaperones ATF6B (ATF6-beta) activates chaperones
Drugs
Diseases		Keratosis follicularis spinulosa decalvans Ichthyosis follicularis, alopecia, and photophobia syndrome
GWAS			A body shape index ( 34021172) Age-related macular degeneration ( 23577725) Autism spectrum disorder or schizophrenia ( 28540026) Automobile speeding propensity ( 30643258) Blood protein levels in cardiovascular risk ( 28369058) Coronary artery disease ( 32469254) Inflammatory bowel disease ( 28067908) Intraocular pressure ( 29617998) Mean corpuscular volume ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Prostate cancer ( 23535732) Takayasu arteritis ( 25604533) Ulcerative colitis ( 28067908) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		2 interacting genes: ATF6B BDNF	10 interacting genes: ATF6 CDK6 CREBZF LHX8 MBTPS1 MBTPS2 NFYA NFYC PHOX2A XBP1
Entrez ID		51360	1388
HPRD ID		02243	02992
Ensembl ID		ENSG00000012174	ENSG00000213676
Uniprot IDs		O43462	A0A1U9X796 Q6AZW6 Q99941
PDB IDs
Enriched GO Terms of Interacting Partners?		Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Negative Regulation Of ATF6-mediated Unfolded Protein Response Regulation Of ATF6-mediated Unfolded Protein Response Nerve Growth Factor Receptor Binding ATF6-mediated Unfolded Protein Response Positive Regulation Of Collateral Sprouting Nerve Growth Factor Signaling Pathway Negative Regulation Of Myotube Differentiation Collateral Sprouting Regulation Of Collateral Sprouting Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Neurotrophin Signaling Pathway	ATF6-mediated Unfolded Protein Response ER-nucleus Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response RNA Polymerase II Transcription Regulator Complex Response To Endoplasmic Reticulum Stress Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Biosynthetic Process DNA-binding Transcription Factor Activity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process CCAAT-binding Factor Complex Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Transcription Cis-regulatory Region Binding Positive Regulation Of RNA Metabolic Process Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Membrane Protein Intracellular Domain Proteolysis Regulation Of G2/M Transition Of Mitotic Cell Cycle RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Lipid Metabolic Process Regulation Of Gene Expression Positive Regulation Of Cholesterol Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process NLS-bearing Protein Import Into Nucleus Cellular Response To Stress Neuron Development Positive Regulation Of Cholesterol Metabolic Process Regulation Of Cholesterol Biosynthetic Process Regulation Of Lipid Biosynthetic Process Membrane Protein Proteolysis Mitotic G2 DNA Damage Checkpoint Signaling Positive Regulation Of Steroid Biosynthetic Process Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of Macromolecule Metabolic Process Sequence-specific Double-stranded DNA Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress
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