CRNKL1 and PPIL2

Number of citations of the paper that reports this interaction (PubMedID 15189447)
0

Data Source:
HPRD (two hybrid, in vivo)

		CRNKL1	PPIL2
Description		crooked neck pre-mRNA splicing factor 1	peptidylprolyl isomerase like 2
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GO Annotations	Cellular Component	Prp19 Complex Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome Post-mRNA Release Spliceosomal Complex	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Golgi Lumen Plasma Membrane Catalytic Step 2 Spliceosome
	Molecular Function	RNA Binding Protein Binding	Peptidyl-prolyl Cis-trans Isomerase Activity Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Spliceosomal Complex Assembly MRNA Splicing, Via Spliceosome RNA Processing MRNA Processing RNA Splicing	Protein Polyubiquitination MRNA Processing Protein Folding RNA Splicing Protein Ubiquitination Protein Localization To Plasma Membrane
Pathways		mRNA Splicing - Major Pathway	Basigin interactions mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS			Bipolar disorder ( 31043756) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926) Type 1 diabetes in high risk HLA genotype individuals (time to event) ( 29310926)
Interacting Genes		7 interacting genes: BID CLK1 HSP90AA1 HSPB1 NRIP1 PPIL2 RNF10	12 interacting genes: APP BSG CALM1 CEBPA CRNKL1 HSP90AA1 PLK1 PRCC SNAI1 TRIM23 ZDHHC8 ZNF830
Entrez ID		51340	23759
HPRD ID		09898	08472
Ensembl ID		ENSG00000101343	ENSG00000100023
Uniprot IDs		Q5JY65 Q9BZJ0	A0A7P0TBL3 A8K0I0 Q13356
PDB IDs		5MQF 5XJC 5YZG 5Z56 5Z57 5Z58 6FF4 6FF7 6ICZ 6ID0 6ID1 6QDV 6ZYM 7A5P 7ABI 7DVQ 7QTT 7W59 7W5A 7W5B 8C6J 8CH6 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 8RO2 9FMD	1ZKC 7ABI 7DVQ 7QTT 8CH6 8I0P 8I0R 8I0S 8I0T
Enriched GO Terms of Interacting Partners?		Protein Folding Protein Refolding Establishment Of Protein Localization To Mitochondrion Protein Folding Chaperone Negative Regulation Of Protein Kinase C Signaling CTP Binding DATP Binding Ovarian Follicle Rupture Response To Unfolded Protein Response To Heat Cysteine-type Endopeptidase Regulator Activity Involved In Apoptotic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Unfolded Protein Binding Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Protein Kinase C Inhibitor Activity Rho GDP-dissociation Inhibitor Binding Histone Deacetylase Binding Response To Temperature Stimulus Cellular Localization Regulation Of Protein Kinase C Signaling Sperm Mitochondrial Sheath Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane	Positive Regulation Of Protein Catabolic Process Positive Regulation Of Protein Localization Positive Regulation Of Catabolic Process Regulation Of Cell Cycle Response To Metal Ion Notch Signaling Pathway Regulation Of Protein Catabolic Process Regulation Of Protein Localization To Nucleus Myelin Sheath Positive Regulation Of Proteolysis Amyloid-beta Complex Regulation Of Cell Junction Assembly Growth Cone Lamellipodium Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Blood Circulation Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Neuron Recognition Regulation Of Protein Localization Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Protein Transport Spindle Microtubule Cell Cycle G2/M Phase Transition G2/M Transition Of Mitotic Cell Cycle RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding CTP Binding DATP Binding Mitotic G2/M Transition Checkpoint Acetylcholine Receptor Activator Activity PTB Domain Binding Developmental Growth Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Metabolic Process Reproductive Process Positive Regulation Of Interleukin-6 Production Regulation Of Proteolysis Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Apoptotic Process Protein-containing Complex Regulation Of Calcium-mediated Signaling Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Transport Positive Regulation Of Protein Import
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