ZDHHC3 and GABRG2

Number of citations of the paper that reports this interaction (PubMedID 15229235)
62

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		ZDHHC3	GABRG2
Description		zDHHC palmitoyltransferase 3	gamma-aminobutyric acid type A receptor subunit gamma2
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Membrane	Plasma Membrane Membrane Axon Dendrite Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Dendrite Membrane Chloride Channel Complex Cell Projection Dendritic Spine Synapse Postsynaptic Membrane Postsynapse GABA-ergic Synapse Postsynaptic Specialization Membrane GABA-A Receptor Complex
	Molecular Function	Palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity Protein Homodimerization Activity Protein-cysteine S-stearoyltransferase Activity	Transmembrane Signaling Receptor Activity GABA-A Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Chloride Channel Activity Protein Binding Benzodiazepine Receptor Activity GABA-gated Chloride Ion Channel Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Protein Targeting Protein Targeting To Membrane Regulation Of G Protein-coupled Receptor Signaling Pathway Peptidyl-L-cysteine S-palmitoylation Protein Palmitoylation Cellular Response To Nutrient Levels Positive Regulation Of Synaptic Transmission, GABAergic Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Toll-like Receptor 9 Signaling Pathway TRAIL-activated Apoptotic Signaling Pathway Lipoprotein Localization To Membrane Protein Localization To Membrane Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Lysosome Positive Regulation Of Receptor Localization To Synapse Protein Localization To Photoreceptor Outer Segment Positive Regulation Of TORC1 Signaling	Monoatomic Ion Transport Chloride Transport Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Post-embryonic Development Adult Behavior Monoatomic Ion Transmembrane Transport Synaptic Transmission, GABAergic Regulation Of Postsynaptic Membrane Potential Cellular Response To Histamine Chloride Transmembrane Transport Inhibitory Synapse Assembly
Pathways		Maturation of spike protein	Signaling by ERBB4 GABA receptor activation GABA receptor activation
Drugs			Lorazepam Lorazepam Ethchlorvynol Enflurane Temazepam Temazepam Butabarbital Butalbital Phenytoin Etomidate Talbutal Pentobarbital Olanzapine Clobazam Clobazam Meprobamate Carisoprodol Eszopiclone Alprazolam Alprazolam Zolpidem Metharbital Chlordiazepoxide Chlordiazepoxide Amoxapine Adinazolam Adinazolam Lamotrigine Lamotrigine Medroxyprogesterone acetate Clorazepic acid Clorazepic acid Midazolam Midazolam Flurazepam Flurazepam Isoflurane Primidone Halazepam Halazepam Propofol Diazepam Diazepam Oxazepam Oxazepam Triazolam Triazolam Zonisamide Methoxyflurane Memantine Clonazepam Clonazepam Methyprylon Halothane Desflurane Flumazenil Flumazenil Estazolam Estazolam Sevoflurane Ginkgo biloba Glutethimide Camazepam Camazepam Delorazepam Delorazepam Flunitrazepam Flunitrazepam Ethyl loflazepate Ethyl loflazepate Cloxazolam Cloxazolam Bromazepam Bromazepam Clotiazepam Clotiazepam Fludiazepam Ketazolam Ketazolam Prazepam Prazepam Quazepam Quazepam Cinolazepam Cinolazepam Nitrazepam Nitrazepam Prasterone Taurine Ganaxolone Adipiplon Brotizolam Brotizolam Stiripentol Etizolam Etizolam Thiocolchicoside Brexanolone Apalutamide Remimazolam Remimazolam Muscimol 1,2-Benzodiazepine 1,2-Benzodiazepine Pinazepam Pinazepam Medazepam Medazepam Loprazolam Loprazolam Doxefazepam Doxefazepam Lormetazepam Lormetazepam 5,7,2′-trihydroxy-6,8-dimethoxyflavone Nordazepam Nordazepam Oxazepam acetate Oxazepam acetate Cinazepam Cinazepam Bentazepam Bentazepam Mexazolam Mexazolam
Diseases			Febrile seizures, including: Febrile convulsions; Generalized epilepsy with febrile seizure plus (GEFS+); Dravet syndrome/ Severe myoclonic epilepsy in infancy (SMEI) Idiopathic generalied epilepsies (IGEs), including: Childhood absence epilepsy (CAE); Juvenile absence epilepsy (JAE); Juvenile myoclonic epilepsy (JME); Epilepsy with generalized tonic-clonic seizures alone
GWAS		Acne (severe) ( 24927181) Bipolar disorder ( 31043756) Cerebrospinal fluid t-tau:AB1-42 ratio ( 30153862) Depressive symptom improvement ( 30468137)	Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Cognitive decline rate in late mild cognitive impairment ( 26252872) Femur bone mineral density x serum urate levels interaction ( 34046847) Glucagon levels in response to oral glucose tolerance test (decremental area under the curve for 0-30 minutes) ( 33407418) Nicotine dependence symptom count ( 25555482) Parkinson's disease motor subtype (tremor dominant vs postural instability/gait difficulty) ( 33987465) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Severe influenza A (H1N1) infection ( 26379185)
Interacting Genes		6 interacting genes: EWSR1 GABRG2 GPR35 NEDD4L SMAD1 UBQLN4	9 interacting genes: CFTR DRD5 GABARAP GABRA2 LARP7 PPP3CA PRKCA PRKCB ZDHHC3
Entrez ID		51304	2566
HPRD ID		15718	00663
Ensembl ID		ENSG00000163812	ENSG00000113327
Uniprot IDs		A0A994J7J2 F8W6M3 H0Y6A5 Q9NYG2	A0A1W2PQR9 A0A1W2PR49 A0A1W2PRN4 A0A1X7SBZ8 A8MWU7 P18507
PDB IDs			6D6T 6D6U 6HUG 6HUJ 6HUK 6HUO 6HUP 6I53 6X3S 6X3T 6X3U 6X3V 6X3W 6X3X 6X3Z 6X40 7QNB 7QNE 7T0W 7T0Z 8DD2 8DD3 8SGO 8SI9 8SID 8VQY 8VRN 9CRS 9CRV 9CSB 9CT0 9CTJ 9CTP 9CTV 9CX7 9CXA 9CXB 9CXC 9CXD 9DRX 9EQG
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Monoatomic Ion Transport Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Mesodermal Cell Fate Commitment Homomeric SMAD Protein Complex Osteoblast Fate Commitment Regulation Of Dendrite Development Negative Regulation Of Sodium Ion Import Across Plasma Membrane Negative Regulation Of Autophagosome Maturation Nuclear Proteasome Complex Positive Regulation Of Caveolin-mediated Endocytosis	Positive Regulation Of Angiotensin-activated Signaling Pathway Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Histone H3T6 Kinase Activity Regulation Of Exocytosis Positive Regulation Of Protein Localization Regulation Of Protein Localization Protein Kinase C Signaling Regulation Of Angiotensin-activated Signaling Pathway Positive Regulation Of Exocytosis Positive Regulation Of Insulin Secretion Positive Regulation Of Secretion By Cell Positive Regulation Of Secretion Mitotic Nuclear Membrane Disassembly Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Nuclear Membrane Disassembly Membrane Disassembly Diacylglycerol-dependent Serine/threonine Kinase Activity Monoatomic Ion Transport Regulation Of Biological Quality Positive Regulation Of Protein Secretion Positive Regulation Of Hormone Secretion Renal Sodium Ion Absorption Regulation Of G Protein-coupled Receptor Signaling Pathway Renal Sodium Ion Transport Regulation Of Insulin Secretion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Modulation Of Chemical Synaptic Transmission Regulation Of Receptor Localization To Synapse Regulation Of Vesicle-mediated Transport Regulation Of Peptide Hormone Secretion Regulation Of Secretion By Cell Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Secretion Renal Absorption Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Transport Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Hormone Secretion Regulation Of Protein Secretion Regulation Of Synaptic Vesicle Exocytosis Nuclear Membrane Organization Chloride Channel Complex Regulation Of Cell Communication Regulation Of Signaling Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity
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