NRN1 and SMN1

Number of citations of the paper that reports this interaction (PubMedID 30165668)
80

Data Source:
BioGRID (unspecified method)

		NRN1	SMN1
Description		neuritin 1	survival of motor neuron 1, telomeric
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane AMPA Glutamate Receptor Complex Synapse Side Of Membrane Presynapse Glutamatergic Synapse	Nucleus Nucleoplasm Cytoplasm Cytosol Cajal Body Nuclear Body Z Disc Axon SMN Complex SMN-Sm Protein Complex Cytoplasmic Ribonucleoprotein Granule Cell Projection Neuron Projection Perikaryon Gemini Of Cajal Bodies
	Molecular Function	Identical Protein Binding	RNA Binding Protein Binding Identical Protein Binding
	Biological Process	Nervous System Development Regulation Of Synapse Maturation Presynaptic Modulation Of Chemical Synaptic Transmission Neuron Projection Extension	Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions Spliceosomal SnRNP Assembly DNA-templated Transcription Termination MRNA Processing Nervous System Development RNA Splicing
Pathways		Post-translational modification: synthesis of GPI-anchored proteins	snRNP Assembly SARS-CoV-2 modulates host translation machinery
Drugs			Nusinersen
Diseases			Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS		Hippocampal volume in Alzheimer's disease dementia ( 29274321) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917)
Interacting Genes		2 interacting genes: CD36 SMN1	166 interacting genes: A1BG A2M ACTB ACTL6B ADAMTS10 AGAP1 ANXA2 APLP1 ARFGAP1 ATP5F1B ATP6V1A BAG6 BCL2 BLOC1S6 BYSL CARHSP1 CCDC90B CENPB CHTOP COIL COL4A2 COL4A5 COPS6 CPNE6 CRIP2 CSAD DDAH2 DDX20 DHX9 DMPK DOCK7 DUS2 DYNC1I1 EEF1A1 EEF1A2 EHHADH EIF3G EXT2 EZH2 FAM20C FAM9B FBL FGB FLAD1 FNDC11 FUBP1 FXR1 GAPDH GAR1 GDF9 GEMIN2 GEMIN5 GEMIN7 H3-4 HADHB HMGXB3 HNRNPR HNRNPU HNRNPUL1 IGHM ILF3 IMMT INPP5K IQUB ITCH JADE1 KDM1A KIF5A KLHL5 KMT2B KPNB1 KRTAP19-6 KRTAP19-7 KRTAP21-2 KRTAP6-1 KRTAP6-2 LENG8 LRIF1 LSM1 LSM10 LSM11 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 MAGED1 MAST2 MED31 MKI67 MPP1 MRPL37 MSH2 NEURL2 NGFR NKIRAS2 NMT2 NRN1 NTAQ1 OSTF1 PDE4DIP PKM PLXNA3 POLR1C POLR2A POP7 PPIG PSME1 QARS1 RBBP4 RBBP6 RBFOX2 RBM48 REX1BD RN7SL1 RNU1-1 RNU11 RNU2-1 RNU4-1 RPL13 RPS2 RXRA SCARNA1 SDF4 SELENOW SEMA5B SETDB1 SMC5 SMN2 SNORA81 SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNU13 SNUPN SP110 SPANXN2 STRAP STXBP2 STXBP3 SULT1A3 SUMO3 SYNCRIP TAF1C TERC TIAL1 TLE1 TMSB4X TP53 TRMT2A TUBA1A TUBB3 UCHL1 UNC119 USP4 VPS28 WDR18 WDR73 WIZ ZBTB16 ZNF431 ZRANB2 ZXDC
Entrez ID		51299	6606
HPRD ID		07592	02646
Ensembl ID		ENSG00000124785	ENSG00000172062
Uniprot IDs		A0A087WWT2 Q9NPD7	B4DP61 E7EQZ4 Q16637
PDB IDs			1G5V 1MHN 2LEH 4A4E 4A4G 4GLI 4QQ6 5XJL 5XJQ 5XJR 5XJS 5XJT 5XJU 7W2P 7W30
Enriched GO Terms of Interacting Partners?		Intestinal Cholesterol Absorption Response To Bacterial Lipoprotein Positive Regulation Of Cholesterol Storage Lipoprotein Particle Binding Oleate Transmembrane Transporter Activity Cellular Response To Lipoteichoic Acid Regulation Of Removal Of Superoxide Radicals Short-chain Fatty Acid Transport Regulation Of Response To Reactive Oxygen Species Response To Linoleic Acid Response To Stilbenoid Nitric Oxide-cGMP-mediated Signaling Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Cholesterol Import Intestinal Lipid Absorption Amyloid-beta Clearance By Cellular Catabolic Process Toll-like Receptor Binding Cellular Response To Hydroperoxide Lipoteichoic Acid Immune Receptor Activity Long-chain Fatty Acid Import Across Plasma Membrane Thrombospondin Receptor Activity Long-chain Fatty Acid Import Into Cell Cellular Response To Bacterial Lipopeptide Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Phagocytosis, Engulfment Short-chain Fatty Acid Transmembrane Transporter Activity Lipid Transport Across Blood-brain Barrier Cellular Response To Diacyl Bacterial Lipopeptide Positive Regulation Of Blood Microparticle Formation Lipid Import Into Cell Oxidised Low-density Lipoprotein Particle Receptor Activity High-density Lipoprotein Particle Binding Triglyceride Transport Low-density Lipoprotein Particle Mediated Signaling Phagocytosis, Recognition Oxidised Low-density Lipoprotein Particle Clearance SMN Complex Gemini Of Cajal Bodies Lipoprotein Transport Low-density Lipoprotein Particle Binding Platelet Alpha Granule Membrane Long-chain Fatty Acid Transmembrane Transporter Activity Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Low-density Lipoprotein Particle Receptor Activity Low-density Lipoprotein Particle Clearance SMN-Sm Protein Complex Negative Regulation Of Protein Import Into Nucleus Positive Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Cellular Response To Oxidative Stress Response To Hydroperoxide	Spliceosomal SnRNP Assembly RNA Binding MRNA Metabolic Process RNA Splicing MRNA Processing RNA Splicing, Via Transesterification Reactions SMN-Sm Protein Complex RNA Processing Ribonucleoprotein Complex U4/U6 X U5 Tri-snRNP Complex Protein-RNA Complex Assembly MRNA Splicing, Via Spliceosome RNA Metabolic Process U2-type Precatalytic Spliceosome Spliceosomal Complex Lsm2-8 Complex Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process U6 SnRNP Lsm1-7-Pat1 Complex Nucleoplasm Precatalytic Spliceosome SMN Complex U4 SnRNP Catalytic Step 2 Spliceosome Telomerase Holoenzyme Complex U7 SnRNP Macromolecule Metabolic Process 7-methylguanosine Cap Hypermethylation Small Nuclear Ribonucleoprotein Complex Nucleus Gemini Of Cajal Bodies Methylosome U12-type Spliceosomal Complex PICln-Sm Protein Complex Spliceosomal Tri-snRNP Complex Cytosol U2 SnRNP Spliceosomal Complex Assembly Protein-containing Complex Assembly U1 SnRNP U7 SnRNA Binding U5 SnRNP Cytoplasm Cajal Body Histone Pre-mRNA DCP Binding U2-type Prespliceosome Assembly Protein-containing Complex Organization U6 SnRNA Binding Promoter-specific Chromatin Binding
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