BPIFA1 and SIRPB1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		BPIFA1	SIRPB1
Description		BPI fold containing family A member 1	signal regulatory protein beta 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Cell Surface Membrane Secretory Granule Membrane
	Molecular Function	Protein Binding Lipid Binding	Protein Binding
	Biological Process	Immune System Process Immune Response In Nasopharyngeal-associated Lymphoid Tissue Antibacterial Humoral Response Defense Response To Bacterium Surfactant Homeostasis Innate Immune Response Multicellular Organismal-level Water Homeostasis Defense Response To Virus Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Negative Regulation Of Single-species Biofilm Formation In Or On Host Organism Regulation Of Sodium Ion Transmembrane Transport	Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Phagocytosis Positive Regulation Of T Cell Activation
Pathways		Antimicrobial peptides	DAP12 interactions Signal regulatory protein family interactions Neutrophil degranulation
Drugs
Diseases
GWAS			Blood protein levels ( 30072576) Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 27863252 32888494) Metabolite levels ( 23823483) Monocyte count ( 32888494) Neutrophil count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Systemic lupus erythematosus ( 33536424) White blood cell count ( 32888494)
Interacting Genes		50 interacting genes: ALKBH4 COL8A1 CRYBA2 CSKMT DUSP21 ELK3 EML2 FAAP20 FAM222B GADD45GIP1 GCA HCK HNF1B HOXB9 HSFY1 HSFY2 INCA1 INIP KIR2DL4 KRT3 LNX1 MEIS2 MKRN3 MTIF3 NPAS2 NUP54 PATZ1 PEF1 PITX1 PPIH PRR35 PSMB1 RAMAC RSPH14 RTP5 RUSC1 SAMD11 SIRPB1 SNRNP25 TCF7L2 TEPSIN TFG TIAL1 TLE5 TLX3 UBQLN1 UBQLN2 UBQLN4 VPS25 ZNF765	7 interacting genes: APOC1 BPIFA1 DAB1 MEOX2 RBFOX1 RBPMS TYROBP
Entrez ID		51297	10326
HPRD ID		07594	04866
Ensembl ID		ENSG00000198183	ENSG00000101307
Uniprot IDs		Q9NP55	H9KV29 O00241 Q5TFQ8
PDB IDs		4KEG 4KGH 4KGO 4N4X 5I7J 5I7K 5I7L	2D9C 2JJU 2JJV
Enriched GO Terms of Interacting Partners?		Protein Binding Polyubiquitin Modification-dependent Protein Binding Nucleus Myoblast Fate Commitment Pancreas Development DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin	Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Negative Regulation Of Phosphatidylcholine Catabolic Process Regulation Of Phosphatidylcholine Catabolic Process Lateral Motor Column Neuron Migration Cerebellum Structural Organization Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Spinal Cord Motor Neuron Migration Radial Glia Guided Migration Of Purkinje Cell Positive Regulation Of Osteoclast Development Positive Regulation Of Microglial Cell Mediated Cytotoxicity Positive Regulation Of Receptor Localization To Synapse Stimulatory Killer Cell Immunoglobulin-like Receptor Signaling Pathway Positive Regulation Of Macrophage Fusion Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Cytoplasmic Stress Granule Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA CDS Binding Immune Response In Nasopharyngeal-associated Lymphoid Tissue Immune Response In Gut-associated Lymphoid Tissue Negative Regulation Of Single-species Biofilm Formation In Or On Host Organism Phosphatidylcholine-sterol O-acyltransferase Activator Activity Negative Regulation Of Triglyceride Catabolic Process Very-low-density Lipoprotein Particle Clearance Chylomicron Remnant Clearance Triglyceride-rich Lipoprotein Particle Clearance Radial Glia-guided Pyramidal Neuron Migration Somite Specification Microglial Cell Activation Involved In Immune Response Molecular Adaptor Activity Negative Regulation Of Transforming Growth Factor Beta1 Production Regulation Of RNA Splicing Regulation Of Phospholipid Catabolic Process Lipase Inhibitor Activity Ventral Spinal Cord Development T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Nuclear Stress Granule Phospholipase Inhibitor Activity Regulation Of Osteoclast Development Regulation Of Phosphatidylcholine Metabolic Process Very-low-density Lipoprotein Particle Assembly Cell Migration In Hindbrain Reelin-mediated Signaling Pathway Neutrophil Activation Involved In Immune Response Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Transforming Growth Factor Beta Production Pre-mRNA Intronic Binding MRNA Binding Chylomicron Phospholipid Efflux
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