DNAJC27 and RAB10

		DNAJC27	RAB10
Description		DnaJ heat shock protein family (Hsp40) member C27	RAB10, member RAS oncogene family
Image
GO Annotations	Cellular Component	Nucleus Organelle Membrane Cytoplasmic Vesicle	Golgi Membrane Exocyst Cytoplasm Lysosome Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion Cilium Endosome Membrane Membrane Cytoplasmic Vesicle Membrane Secretory Granule Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Insulin-responsive Compartment Cell Projection Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Exocytic Vesicle Endoplasmic Reticulum Tubular Network Secretory Vesicle
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Myosin V Binding Cadherin Binding Involved In Cell-cell Adhesion
	Biological Process	Intracellular Protein Transport Positive Regulation Of ERK1 And ERK2 Cascade	Exocytosis Golgi To Plasma Membrane Transport Axonogenesis Protein Transport Vesicle-mediated Transport Endosomal Transport Antigen Processing And Presentation Polarized Epithelial Cell Differentiation Cellular Response To Insulin Stimulus Golgi To Plasma Membrane Protein Transport Regulated Exocytosis Establishment Of Neuroblast Polarity Endoplasmic Reticulum Tubular Network Organization Protein Localization To Plasma Membrane Establishment Of Protein Localization To Membrane Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Cell-cell Adhesion Protein Localization To Basolateral Plasma Membrane
Pathways			Translocation of SLC2A4 (GLUT4) to the plasma membrane Neutrophil degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Body mass index ( 22344219 26426971 28892062) Body mass index (age <50) ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Crohn's disease ( 28067908) Height ( 20881960 31562340) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Obese vs. thin ( 30677029) Obesity (extreme) ( 30677029) Pre-treatment viral load in HIV-1 infection ( 31219150) Pubertal anthropometrics ( 23449627) Type 1 diabetes ( 21980299)	Apolipoprotein B levels ( 32203549) Glycated hemoglobin levels ( 34059833) Immune response to smallpox vaccine (IL-6) ( 22542470) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 27863252 32888494) Metabolite levels (HVA) ( 23319000) Metabolite levels (HVA-5-HIAA Factor score) ( 23319000) Metabolite levels (HVA/MHPG ratio) ( 23319000) Platelet distribution width ( 32888494)
Interacting Genes		2 interacting genes: IFT172 RAB10	18 interacting genes: APP ATRAID CEBPA DNAJC27 EFR3B ENOPH1 EVI5L GPN1 IFT172 MICAL1 MTNR1A PLP2 PPBP PREB RABIF RIMS1 SEPTIN9 TP53I3
Entrez ID		51277	10890
HPRD ID		15221	06692
Ensembl ID		ENSG00000115137	ENSG00000084733
Uniprot IDs		Q9NZQ0	P61026
PDB IDs		2YS8	5LPN 5SZJ
Enriched GO Terms of Interacting Partners?		Protein Localization To Basolateral Plasma Membrane Establishment Of Neuroblast Polarity Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Hindgut Development Sperm Cytoplasmic Droplet Intraciliary Transport Particle Insulin-responsive Compartment Cilium Secretory Vesicle Neural Tube Formation Cadherin Binding Involved In Cell-cell Adhesion Endoplasmic Reticulum Tubular Network Organization Exocytic Vesicle Myosin V Binding Exocyst Endoplasmic Reticulum Tubular Network Polarized Epithelial Cell Differentiation Embryonic Epithelial Tube Formation Left/right Axis Specification Negative Regulation Of Keratinocyte Proliferation Intraciliary Transport Particle B Embryonic Eye Morphogenesis Embryonic Camera-type Eye Morphogenesis Spinal Cord Motor Neuron Differentiation Intraciliary Anterograde Transport Sperm Principal Piece Keratinocyte Proliferation Golgi To Plasma Membrane Protein Transport Cell Projection Organization Establishment Of Protein Localization To Endoplasmic Reticulum Epithelial Tube Formation Negative Regulation Of Smoothened Signaling Pathway Cell Differentiation In Spinal Cord Positive Regulation Of Smoothened Signaling Pathway Intracellular Transport Neural Tube Development Cell Projection Ciliary Tip Regulation Of Keratinocyte Proliferation Intraciliary Transport Sperm Midpiece Non-motile Cilium Assembly Digestive Tract Development Limb Development Endoplasmic Reticulum Organization Cellular Localization Anatomical Structure Morphogenesis Establishment Of Protein Localization To Plasma Membrane Establishment Of Localization In Cell Golgi To Plasma Membrane Transport
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?