TUBE1 and DPAGT1

		TUBE1	DPAGT1
Description		tubulin epsilon 1	dolichyl-phosphate N-acetylglucosaminephosphotransferase 1
Image		No pdb structure
GO Annotations	Cellular Component	Pericentriolar Material Cytoplasm Centrosome Cytoskeleton Microtubule Microtubule Cytoskeleton	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Nucleotide Binding Structural Constituent Of Cytoskeleton GTP Binding	UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase Activity UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Phosphotransferase Activity, For Other Substituted Phosphate Groups Identical Protein Binding Metal Ion Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Centrosome Cycle	Protein Glycosylation Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process
Pathways			Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective DPAGT1 causes CDG-1j, CMSTA2
Drugs		Vinblastine
Diseases			Congenital disorders of glycosylation (CDG) type I
GWAS			Estimated glomerular filtration rate ( 31152163) Lymphocyte percentage of white cells ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes			2 interacting genes: LSM8 SLC33A2
Entrez ID		51175	1798
HPRD ID		06298	01879
Ensembl ID		ENSG00000074935	ENSG00000172269
Uniprot IDs		Q9UJT0	A0A804HI18 A0A804HKZ3 Q9H3H5
PDB IDs			5LEV 5O5E 6BW5 6BW6 6FM9 6FWZ 6JQ3
Enriched GO Terms of Interacting Partners?		UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase Activity Negative Regulation Of Anion Channel Activity UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase Activity
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