INSIG2 and VMA21

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		INSIG2	VMA21
Description		insulin induced gene 2	vacuolar ATPase assembly factor VMA21
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane SREBP-SCAP-Insig Complex	Lysosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane ER To Golgi Transport Vesicle Membrane Membrane Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Protein Binding Oxysterol Binding Lipid Binding Protein Sequestering Activity	Protein Binding
	Biological Process	NLS-bearing Protein Import Into Nucleus Lipid Metabolic Process Triglyceride Metabolic Process Cholesterol Biosynthetic Process Response To Sterol Depletion Steroid Metabolic Process Cholesterol Metabolic Process Negative Regulation Of Steroid Biosynthetic Process Sterol Biosynthetic Process Response To Insulin Cellular Response To Insulin Stimulus SREBP Signaling Pathway Response To Lipid SREBP-SCAP Complex Retention In Endoplasmic Reticulum Inner Ear Morphogenesis Middle Ear Morphogenesis Positive Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Fatty Acid Biosynthetic Process Protein Maturation Roof Of Mouth Development Cranial Suture Morphogenesis Response To Fatty Acid	Lysosomal Lumen Acidification Vacuolar Proton-transporting V-type ATPase Complex Assembly
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF)
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Cholesterol, total ( 24097068) Depression in response to interferon-based therapy in chronic hepatitis C ( 27723809) Heel bone mineral density ( 30598549 28869591) LDL cholesterol ( 30275531 24097068) LDL cholesterol levels ( 30698716 32203549) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Low density lipoprotein cholesterol levels ( 32154731 33339817) Lumbar spine bone mineral density ( 22504420) Monobrow ( 27182965) Mosquito bite size ( 28199695) Total cholesterol levels ( 30275531)
Interacting Genes		55 interacting genes: ABHD4 AQP2 AQP6 ARL13B ATP6V0B BIK CD40 CD79A CPLX4 CREB3L1 CYBC1 EBP ELOVL4 ERGIC3 FAM209A FAM210B GJA8 GOLM1 GPR152 GPR37L1 GPX8 HSD17B13 IFNGR2 KIR2DL3 LAPTM5 LHFPL5 LMNA MMGT1 MTIF3 MUC1 NEMP1 PCK1 PRLR PSCA PSMA7 PSMB1 PSMC3 PSMC5 PVR RNF5 SCAP SCN3B SLC10A1 SLC16A10 SLC18A1 SLC35H1 SREBF2 STIM1 TMEM14B TMEM237 TMEM45B TMEM52B TMX2 VCP VMA21	29 interacting genes: ABHD16A ADAM33 AQP6 ARL6IP1 ATP13A1 ATP6V0B BNIP1 CDIPT CLEC12B DAGLA HMOX2 INSIG2 LHFPL5 LYPD6B NINJ2 NIPAL3 ORMDL1 PLLP RTP2 SCD SLC25A46 SLC35E4 TECR THSD7A TMEM107 TMEM60 VAMP2 YIF1A YIPF1
Entrez ID		51141	203547
HPRD ID		16361	18578
Ensembl ID		ENSG00000125629	ENSG00000160131
Uniprot IDs		B4DQ23 Q9Y5U4	Q3ZAQ7
PDB IDs		4J82 6M49 7ETW
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Proteasome Complex Endoplasmic Reticulum C-8 Sterol Isomerase Activity Positive Regulation Of Cholesterol Biosynthetic Process Cytoplasmic Vesicle Positive Regulation Of Cholesterol Metabolic Process Regulation Of Cholesterol Biosynthetic Process Proteasome-activating Activity Positive Regulation Of Steroid Biosynthetic Process Protein Binding Renal Water Transport Positive Regulation Of Lipid Biosynthetic Process Positive Regulation Of Steroid Metabolic Process SREBP Signaling Pathway Cellular Response To Sterol Depletion Regulation Of Cholesterol Metabolic Process Response To Sterol Depletion Proteasome Regulatory Particle, Base Subcomplex	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Membrane Organization Endoplasmic Reticulum Monoacylglycerol Lipase Activity Lipid Biosynthetic Process Acylglycerol Metabolic Process Neutral Lipid Metabolic Process Establishment Of Protein Localization To Membrane Craniofacial Suture Morphogenesis Myelination Axon Ensheathment Acylglycerol Catabolic Process Nitrate Transmembrane Transporter Activity SNAP Receptor Activity Lipid Metabolic Process Glycerolipid Metabolic Process Monounsaturated Fatty Acid Biosynthetic Process CDP-diacylglycerol-inositol 3-phosphatidyltransferase Activity Extraction Of Mislocalized Protein From ER Membrane ABC-type Manganese Transporter Activity Membrane Protein Dislocase Activity
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