TNNI3K and TNNI3

Number of citations of the paper that reports this interaction (PubMedID 12721663)
0

Data Source:
HPRD (two hybrid, in vivo)

		TNNI3K	TNNI3
Description		TNNI3 interacting kinase	troponin I3, cardiac type
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm	Cytoplasm Cytosol Troponin Complex Myofibril Sarcomere Contractile Muscle Fiber Cardiac Myofibril Cardiac Troponin Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Actin Binding Protein Binding Calcium Channel Inhibitor Activity Protein Kinase Binding Protein Domain Specific Binding Troponin C Binding Troponin T Binding Calcium-dependent Protein Binding Actin Filament Binding
	Biological Process	Regulation Of Heart Rate Protein Phosphorylation Peptidyl-serine Autophosphorylation Regulation Of Cardiac Muscle Contraction Bundle Of His Cell To Purkinje Myocyte Communication Regulation Of Cardiac Conduction	Vasculogenesis Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Skeletal Muscle Contraction Intracellular Calcium Ion Homeostasis Regulation Of Muscle Contraction Regulation Of Smooth Muscle Contraction Striated Muscle Contraction Heart Development Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Muscle Filament Sliding Negative Regulation Of ATP-dependent Activity Ventricular Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction
Pathways			Striated Muscle Contraction Ion homeostasis
Drugs		Fostamatinib	N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide
Diseases			Hypertrophic cardiomyopathy (HCM)
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 23669352 28892062 26426971 28448500 20935630) Body mass index (age <50) ( 26426971) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Body size at age 10 ( 32376654) Childhood body mass index ( 26604143 33045005) Hip circumference ( 25673412) Menarche (age at onset) ( 27182965 25231870) Mental health study participation (completed survey) ( 31263887) Obesity ( 23563607) Parental longevity (combined parental age at death) ( 29227965) Pubertal anthropometrics ( 23449627) Smoking initiation ( 30617275 33082346) Smoking initiation (ever regular vs never regular) ( 30679032)	Monocyte count ( 32888494) Platelet count ( 32888494)
Interacting Genes		8 interacting genes: ACTA1 ACTC1 AIP FABP3 FBXO4 HADHB MYBPC3 TNNI3	19 interacting genes: ACTA1 HSPB2 LYST MST1 PAPPA PKD2 PKD2L1 PRKCA PSMC5 RASSF10 RCAN3 SOX4 TNNC1 TNNC2 TNNI3K TNNT1 TNNT2 TRIM55 TRIM63
Entrez ID		51086	7137
HPRD ID		18208	11769
Ensembl ID		ENSG00000116783	ENSG00000129991
Uniprot IDs		Q59H18	P19429 Q6FGX2
PDB IDs		4YFF 4YFI 6B5J 7MGJ 7MGK	1J1D 1J1E 1LXF 1MXL 1OZS 2KGB 2KRD 2L1R 2MZP 2N7L 4Y99 5VLN 5W88 5WCL 6KN7 6KN8 6MV3 7JGI 7SC2 7SC3 7SUP 7SVC 7SWG 7SWI 7SXC 7SXD 7UH9 7UHA 7UTI 7UTL 8DZV 8FMM 8FMN 8FMO 8FMP 8FMQ 8FMR 8FMS 8FMT
Enriched GO Terms of Interacting Partners?		Sarcomere Myosin Binding Cardiac Muscle Contraction Muscle Contraction Mesenchyme Migration Cardiac Muscle Tissue Morphogenesis Muscle System Process Skeletal Muscle Thin Filament Assembly Muscle Tissue Morphogenesis Cardiac Myofibril Striated Muscle Contraction Actin-myosin Filament Sliding Heart Contraction Heart Process Actin-mediated Cell Contraction Ventricular Cardiac Muscle Tissue Morphogenesis Actin Filament-based Movement Icosatetraenoic Acid Binding C Zone Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions GAF Domain Binding Filopodium Cell Body Regulation Of Cardiac Muscle Contraction Actin Filament Actin Filament-based Process Tissue Morphogenesis Oleic Acid Binding Regulation Of Striated Muscle Contraction Blood Microparticle Actomyosin Structure Organization Positive Regulation Of Long-chain Fatty Acid Import Into Cell Acetyl-CoA C-myristoyltransferase Activity Mitochondrial Fatty Acid Beta-oxidation Multienzyme Complex Regulation Of Muscle Filament Sliding Striated Muscle Myosin Thick Filament Cardiac Troponin Complex Troponin C Binding Cytosol Acetyl-CoA C-acyltransferase Activity Troponin T Binding Cytoplasmic Actin-based Contraction Involved In Cell Motility Long-chain Fatty Acid Binding Regulation Of Phosphatidylcholine Biosynthetic Process System Process Acetyl-CoA C-acetyltransferase Activity (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Regulation Of Muscle Contraction Lamellipodium Enoyl-CoA Hydratase Activity	Troponin Complex Regulation Of Muscle System Process Troponin I Binding Muscle Contraction Muscle System Process Regulation Of Muscle Contraction Regulation Of System Process Striated Muscle Contraction Cardiac Troponin Complex Skeletal Muscle Contraction Troponin T Binding Transition Between Fast And Slow Fiber Sarcomere Striated Muscle Thin Filament Response To Water Cytoskeletal Protein Binding Regulation Of Skeletal Muscle Adaptation System Process Contractile Muscle Fiber Tropomyosin Binding Actinin Binding Muscle Alpha-actinin Binding Muscle Filament Sliding Cation Channel Complex Actin-myosin Filament Sliding Spinal Cord Development Non-motile Cilium Monoatomic Cation Channel Activity Sodium Channel Activity Metanephric Cortical Collecting Duct Development Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Sodium Ion Transport Metanephric Cortex Development Metanephric Distal Tubule Development Regulation Of Muscle Filament Sliding Speed Actin-mediated Cell Contraction Cardiac Muscle Contraction Slow-twitch Skeletal Muscle Fiber Contraction Sarcomere Organization Detection Of Chemical Stimulus Involved In Sensory Perception Of Sour Taste Sour Taste Receptor Activity Detection Of Mechanical Stimulus Ventricular Cardiac Muscle Tissue Morphogenesis Response To Mechanical Stimulus Ciliary Membrane Mast Cell Secretory Granule Organization Polycystin Complex Protein Homotetramerization Metanephric Smooth Muscle Tissue Development Mesenchyme Development
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