LAP3 and PIH1D2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LAP3	PIH1D2
Description		leucine aminopeptidase 3	PIH1 domain containing 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Trans-Golgi Network Focal Adhesion Extracellular Exosome	Cytoplasm R2TP Complex Protein Folding Chaperone Complex Ribonucleoprotein Complex
	Molecular Function	Aminopeptidase Activity Carboxypeptidase Activity Protein Binding Peptidase Activity Metalloexopeptidase Activity Hydrolase Activity Manganese Ion Binding Metal Ion Binding Metalloaminopeptidase Activity	Protein Binding Small GTPase Binding
	Biological Process	Proteolysis	Box C/D SnoRNP Assembly RRNA Processing Protein Stabilization
Pathways
Drugs		Leucine Phosphonic Acid (2S)-3-[(R)-[(1S)-1-amino-3-phenylpropyl](hydroxy)phosphoryl]-2-benzylpropanoic acid Zofenoprilat
Diseases
GWAS			Brain morphology (MOSTest) ( 32665545)
Interacting Genes		15 interacting genes: APP BANP CBX3 CBX5 FXR1 LIG4 LINC00632 MAPRE3 OGT PIH1D2 PIK3R3 TAB1 USF1 ZNF76 ZYX	69 interacting genes: ANKRD11 BAG3 BANP CBLL2 CBX8 CCNL2 CDC23 CDCA8 CDKL3 CFAP206 COMMD3 CT55 CTAG1A CTAG1B DES DPH3 DSCAM EIF4A2 EXOSC5 FRS3 GFAP GMCL1 GPRASP2 HES7 HSF4 IGF2BP3 IQUB ITGB3BP KRTAP12-2 KRTAP12-4 LAP3 LMNB1 MCCD1 MDFI MED20 MISP MRFAP1L1 MVP NFIL3 NHSL2 NOTO NTAQ1 NXF1 PBX4 PLEKHJ1 POLR1C PRDM6 PRMT3 RALA REL RSPO4 SDCBP SERTAD1 SLPI SPRED1 SSX3 SUOX TAF6 TASOR2 TBATA TCEA2 TNNI1 TTC23 ZBTB1 ZMAT5 ZNF185 ZNF417 ZNF438 ZNF688
Entrez ID		51056	120379
HPRD ID		07516	14021
Ensembl ID		ENSG00000002549	ENSG00000150773
Uniprot IDs		P28838	Q8WWB5
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription By Glucose Negative Regulation Of Long-term Synaptic Potentiation Protein Serine/threonine Kinase Binding Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Multicellular Organismal Process Pericentric Heterochromatin Amyloid-beta Complex Growth Cone Lamellipodium Chromatin Organization Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Biosynthetic Process Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Macromolecule Biosynthetic Process Establishment Of Integrated Proviral Latency Positive Regulation Of Neurogenesis Chromosome, Telomeric Region Cellular Response To Nutrient Ribonucleoprotein Complex Binding Nuclear Envelope Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Site Of DNA Damage Heterochromatin Regulation Of Glycolytic Process Regulation Of Neuronal Synaptic Plasticity Acetylcholine Receptor Activator Activity Positive Regulation Of Macromolecule Metabolic Process PTB Domain Binding Regulation Of ATP Metabolic Process Regulation Of Macromolecule Biosynthetic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Synapse Organization Negative Regulation Of Gene Expression Epigenetic Regulation Of Gene Expression Regulation Of Carbohydrate Catabolic Process Regulation Of Gene Expression Regulation Of Purine Nucleotide Metabolic Process Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import	Protein Binding Nucleus
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