SHANK1 and ADGRL2

Number of citations of the paper that reports this interaction (PubMedID 10964907)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SHANK1	ADGRL2
Description		SH3 and multiple ankyrin repeat domains 1	adhesion G protein-coupled receptor L2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Membrane Dendrite Neuron Projection Dendritic Spine Synapse Postsynaptic Membrane Excitatory Synapse Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Plasma Membrane Membrane Synapse Postsynaptic Membrane
	Molecular Function	G Protein-coupled Receptor Binding Protein Binding SH3 Domain Binding Signaling Receptor Complex Adaptor Activity Synaptic Receptor Adaptor Activity Somatostatin Receptor Binding Ionotropic Glutamate Receptor Binding Identical Protein Binding Protein-containing Complex Binding Ankyrin Repeat Binding Scaffold Protein Binding Structural Constituent Of Postsynaptic Density	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Latrotoxin Receptor Activity Carbohydrate Binding
	Biological Process	Nervous System Development Long-term Memory Associative Learning Cell Differentiation Adult Behavior Negative Regulation Of Actin Filament Bundle Assembly Social Behavior Protein Localization To Synapse Olfactory Behavior Habituation Modulation Of Chemical Synaptic Transmission Synapse Organization Neuromuscular Process Controlling Balance Cognition Determination Of Affect Righting Reflex Synapse Maturation Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Protein-containing Complex Assembly Vocalization Behavior AMPA Selective Glutamate Receptor Signaling Pathway Maintenance Of Postsynaptic Density Structure Positive Regulation Of Excitatory Postsynaptic Potential	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Excitatory Synapse Assembly
Pathways		Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Carotid plaque maximum area ( 32469969) Clozapine-induced cytotoxicity ( 25656473) Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969)	Cataracts ( 34127677) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 27400856) Estimated glomerular filtration rate after 5 years in renal transplantation (recipient effect) ( 30920136) Impaired insulin sensitivity in response to n-3 PUFA supplementation ( 31779001) Low density lipoprotein cholesterol levels ( 30498476) Major depressive episode treated with electroconvulsive therapy ( 33483693)
Interacting Genes		23 interacting genes: ABCA1 ACE2 ADGRB2 ADGRL1 ADGRL2 ARHGEF7 BAIAP2 DLG4 DLGAP1 DNM2 FXR1 HOMER1 PRMT2 RPS6KA2 RPS6KA3 SHANK3 SHARPIN SPTAN1 SSTR2 STAT1 TANC1 TSC1 USP8	4 interacting genes: MUC1 NCK1 SHANK1 SHANK2
Entrez ID		50944	23266
HPRD ID		05413	06116
Ensembl ID		ENSG00000161681	ENSG00000117114
Uniprot IDs		H9KV90 Q9Y566	A0A6I8PIV6 A0A6I8PLG0 A0A6I8PTT2 A0A8I5KUX3 O95490
PDB IDs		6CPI 6YWZ 6YX0 6YX1 6YX2 7A00 8S1R
Enriched GO Terms of Interacting Partners?		Synapse Postsynaptic Density Neuron Projection Regulation Of Cellular Component Organization Neuron Spine Glutamatergic Synapse Signal Transduction Dendritic Spine Latrotoxin Receptor Activity Cell Projection Modulation Of Chemical Synaptic Transmission Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Cellular Component Organization Regulation Of Supramolecular Fiber Organization Positive Regulation Of Excitatory Postsynaptic Potential Dendritic Spine Organization Postsynapse AMPA Glutamate Receptor Clustering Neuron Projection Organization Ribosomal Protein S6 Kinase Activity Postsynapse Organization Regulation Of Postsynapse Organization Modulation Of Excitatory Postsynaptic Potential Regulation Of Synapse Organization Chemical Synaptic Transmission Learning Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Trans-synaptic Signaling Synaptic Signaling TORC1 Signaling Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Plasma Membrane Scaffold Protein Binding Regulation Of Cell Communication Regulation Of Signaling Endocytic Vesicle Membrane Positive Regulation Of Signal Transduction Neurotransmitter-gated Ion Channel Clustering Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Synaptic Plasticity Axon Regulation Of Signal Transduction PDZ Domain Binding Costamere Cytosol TOR Signaling Regulation Of Biological Quality Positive Regulation Of Developmental Process Postsynaptic Membrane	Synaptic Receptor Adaptor Activity Vocalization Behavior Signaling Receptor Complex Adaptor Activity Ionotropic Glutamate Receptor Binding Social Behavior Associative Learning SH3 Domain Binding Determination Of Affect Somatostatin Receptor Binding Negative Regulation Of Intracellular Signal Transduction Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cap-independent Translational Initiation Eukaryotic Initiation Factor EIF2 Binding Positive Regulation Of Cap-dependent Translational Initiation Dendritic Spine Learning Adult Behavior Structural Constituent Of Postsynaptic Density Regulation Of Signal Transduction Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Habituation Sensory Processing Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Postsynaptic Membrane Maintenance Of Postsynaptic Density Structure AMPA Selective Glutamate Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cytoplasmic Translational Initiation Regulation Of Actin Filament Organization Positive Regulation Of Translation In Response To Stress Postsynaptic Density Learning Or Memory Synapse Organization Nonassociative Learning Ankyrin Repeat Binding Negative Regulation Of Signal Transduction Signal Complex Assembly Regulation Of Translation In Response To Endoplasmic Reticulum Stress Substrate-dependent Cell Migration, Cell Extension Regulation Of Actin Cytoskeleton Organization Regulation Of Translational Initiation In Response To Stress Cognition Neuron Projection Righting Reflex Maintenance Of Postsynaptic Specialization Structure Olfactory Behavior Negative Regulation Of Cell Communication Negative Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of Signaling
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?