PDE11A and AGPS

		PDE11A	AGPS
Description		phosphodiesterase 11A	alkylglycerone phosphate synthase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Mitochondrion Peroxisome Peroxisomal Membrane Peroxisomal Matrix Cytosol Membrane
	Molecular Function	Catalytic Activity Cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity 3',5'-cGMP-stimulated Cyclic-nucleotide Phosphodiesterase Activity Phosphoric Diester Hydrolase Activity Hydrolase Activity CGMP Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity	Catalytic Activity Protein Binding Alkylglycerone-phosphate Synthase Activity Transferase Activity Flavin Adenine Dinucleotide Binding FAD Binding
	Biological Process	Signal Transduction Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of CAMP/PKA Signal Transduction	Lipid Metabolic Process Lipid Biosynthetic Process Ether Lipid Biosynthetic Process
Pathways		cGMP effects G alpha (s) signalling events	Plasmalogen biosynthesis Peroxisomal protein import Peroxisomal protein import TYSND1 cleaves peroxisomal proteins
Drugs		Caffeine Tadalafil Trapidil
Diseases		Pigmented micronodular adrenocortical disease (PPNAD)	Rhizomelic chondrodysplasia punctata, including: Rhizomelic chondrodysplasia punctata, type I (RCDP1); Rhizomelic chondrodysplasia punctata, type II (RCDP2); Rhizomelic chondrodysplasia punctata, type III (RCDP3)
GWAS		Adiponectin levels x Mediterranean diet adherence interaction ( 33562295) Appendicular lean mass ( 33097823) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903) Diastolic blood pressure ( 29212154) Diffusing capacity of carbon monoxide ( 30694715) Heart rate ( 23583979) Heel bone mineral density x serum urate levels interaction ( 34046847) Height ( 20881960 28552196) High myopia ( 31816047 33830181) Hip circumference adjusted for BMI ( 34021172) Myopia ( 27182965) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 30224653)	Height ( 28552196)
Interacting Genes			2 interacting genes: GNPAT GORASP1
Entrez ID		50940	8540
HPRD ID		05391	04337
Ensembl ID		ENSG00000128655	ENSG00000018510
Uniprot IDs		Q9HCR9	B7Z3Q4 O00116
PDB IDs
Enriched GO Terms of Interacting Partners?		Alkylglycerone-phosphate Synthase Activity Ether Lipid Biosynthetic Process FK506 Binding Ether Lipid Metabolic Process FAD Binding Peptidyl-prolyl Cis-trans Isomerase Activity Peroxisomal Matrix Peroxisomal Membrane Flavin Adenine Dinucleotide Binding Peroxisome Isomerase Activity
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