SPOCK3 and SPOCK2

Number of citations of the paper that reports this interaction (PubMedID 12810672)
0

Data Source:
HPRD (in vitro)

		SPOCK3	SPOCK2
Description		SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3	SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix	Extracellular Region Extracellular Space Extracellular Matrix
	Molecular Function	Enzyme Inhibitor Activity Calcium Ion Binding Collagen Binding Glycosaminoglycan Binding Metalloendopeptidase Inhibitor Activity Peptidase Inhibitor Activity Extracellular Matrix Binding	Calcium Ion Binding Protein Binding Collagen Binding Glycosaminoglycan Binding Metalloendopeptidase Inhibitor Activity Extracellular Matrix Binding
	Biological Process	Negative Regulation Of Endopeptidase Activity Negative Regulation Of Cell Motility	Synapse Assembly Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization Regulation Of Cell Differentiation Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Cell Motility
Pathways		Activation of Matrix Metalloproteinases
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Cognitive function ( 28808816) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Immune reponse to smallpox (secreted IL-10) ( 22610502) Medial orbital frontal cortex volume ( 31530798) Obesity-related traits ( 23251661) Total antioxidant status in non-alcoholic fatty liver disease x mastiha supplementation interaction ( 34025683) Verbal declarative memory ( 25648963) Weight ( 28552196)	Blood protein levels ( 30072576) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Insulin-like growth factors ( 21216879) Response to antioxidants and zinc in age-related macular degeneration (disease progression) ( 33751636) Smoking behavior ( 22832964)
Interacting Genes		4 interacting genes: CREB3 MMP14 MMP3 SPOCK2	4 interacting genes: DSCR9 PLXNB3 SPOCK3 TES
Entrez ID		50859	9806
HPRD ID		12147	12146
Ensembl ID		ENSG00000196104	ENSG00000107742
Uniprot IDs		A0A0A0MTJ2 B4DI52 Q9BQ16	Q92563
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Motility Extracellular Matrix Organization Regulation Of Locomotion Extracellular Structure Organization Collagen Catabolic Process Extracellular Matrix Disassembly Extracellular Matrix Collagen Metabolic Process Endopeptidase Activity Metalloendopeptidase Activity Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Locomotion Cellular Response To Genistein Positive Regulation Of Cell Motility Negative Regulation Of GDF15-GFRAL Signaling Pathway Positive Regulation Of Deacetylase Activity Metallopeptidase Activity Serine-type Endopeptidase Activity Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Regulation Of Cell Migration Response To Odorant Response To Genistein Regulation Of Cell-substrate Adhesion Regulation Of Leukocyte Migration GDF15-GFRAL Signaling Pathway Response To Hydroxyisoflavone Macropinosome Release From Viral Latency Astrocyte Cell Migration CCR1 Chemokine Receptor Binding Response To Phenylpropanoid Negative Regulation Of Signal Transduction Cellular Response To UV-A Extracellular Space CAMP Response Element Binding Protein Binding Negative Regulation Of Cell Communication Negative Regulation Of Signaling Response To Oxidative Stress Cellular Response To Stress Response To UV-A Chondrocyte Proliferation Positive Regulation Of Myotube Differentiation Regulation Of Cell Growth Metalloendopeptidase Inhibitor Activity Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Induction Of Positive Chemotaxis Cellular Response To Nitric Oxide Peptidase Activity Cellular Response To Reactive Nitrogen Species	Negative Regulation Of Hydrolase Activity Negative Regulation Of Catalytic Activity Rho GDP-dissociation Inhibitor Binding Semaphorin Receptor Activity Semaphorin Receptor Complex Negative Regulation Of Lamellipodium Assembly Negative Regulation Of GTPase Activity Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Metalloendopeptidase Inhibitor Activity Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Regulation Of Endopeptidase Activity Glycosaminoglycan Binding Regulation Of Catalytic Activity Extracellular Matrix Binding
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