PAFAH1B2 and TIMM50

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PAFAH1B2	TIMM50
Description		platelet activating factor acetylhydrolase 1b catalytic subunit 2	translocase of inner mitochondrial membrane 50
Image			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Extracellular Region Nucleolus Cytoplasm Cytosol Plasma Membrane 1-alkyl-2-acetylglycerophosphocholine Esterase Complex Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Nucleus Nucleoplasm Mitochondrion Mitochondrial Inner Membrane TIM23 Mitochondrial Import Inner Membrane Translocase Complex Endoplasmic Reticulum Golgi Apparatus Membrane Nuclear Speck
	Molecular Function	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Protein Binding Hydrolase Activity Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Protein Heterodimerization Activity Platelet-activating Factor Acetyltransferase Activity	RNA Binding Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Interleukin-2 Receptor Binding Protein Binding Ribonucleoprotein Complex Binding Cysteine-type Endopeptidase Activator Activity
	Biological Process	Lipid Metabolic Process Spermatogenesis Lipid Catabolic Process Positive Regulation Of Macroautophagy	Release Of Cytochrome C From Mitochondria Protein Dephosphorylation Intracellular Protein Transport Mitochondrial Membrane Organization Protein Transport Protein Import Into Mitochondrial Matrix
Pathways		Neutrophil degranulation COPI-independent Golgi-to-ER retrograde traffic	Mitochondrial protein import
Drugs
Diseases
GWAS		Adult body size ( 32376654) Blood protein levels ( 23696881) HDL cholesterol ( 24507774) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Protein quantitative trait loci ( 18464913) Refractive error ( 32231278) Systolic blood pressure ( 30578418)
Interacting Genes		20 interacting genes: ACIN1 ASF1A CCT3 CLVS2 CRK KMT2A PAFAH1B1 PAFAH1B3 PINX1 PPP1R12C PRKN REXO1 RPLP0 SLA SNUPN STAT3 TIMM50 TRIM55 TRIM63 ZFP36L1	6 interacting genes: DNM1 FILNC1 LY6E-DT PAFAH1B2 RAF1 TNFRSF10B
Entrez ID		5049	92609
HPRD ID		03940	12118
Ensembl ID		ENSG00000168092	ENSG00000105197
Uniprot IDs		P68402 V9HW44	Q3ZCQ8
PDB IDs		1VYH
Enriched GO Terms of Interacting Partners?		1-alkyl-2-acetylglycerophosphocholine Esterase Complex Positive Regulation Of Monocyte Differentiation Response To Transforming Growth Factor Beta Cellular Response To Transforming Growth Factor Beta Stimulus Diapedesis Reelin-mediated Signaling Pathway Protein Localization To Organelle Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Positive Regulation Of ATP Biosynthetic Process Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Monocyte Differentiation Regulation Of ATP Biosynthetic Process Negative Regulation Of Glycolytic Process Positive Regulation Of Myeloid Cell Differentiation Phospholipase Binding Negative Regulation Of ATP Metabolic Process Response To Glucocorticoid Intracellular Protein Localization Response To Hormone Microtubule Nucleus Regulation Of JNK Cascade Protein-containing Complex Binding Response To Corticosteroid Negative Regulation Of JNK Cascade Positive Regulation Of Cell Growth Positive Regulation Of ATP Metabolic Process Negative Regulation Of Phosphate Metabolic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process Protein Localization To Mitochondrion Regulation Of Reactive Oxygen Species Biosynthetic Process RNA Binding Cell Population Proliferation Organelle Organization Negative Regulation Of Spontaneous Neurotransmitter Secretion Protein Localization To Nucleus Regulation Of Telomere Maintenance Via Telomerase Phosphotyrosine Residue Binding Regulation Of Myeloid Cell Differentiation Nuclear-transcribed MRNA Catabolic Process, Deadenylation-independent Decay Cellular Response To Raffinose Positive Regulation Of Myeloid Leukocyte Differentiation Regulation Of Erythrocyte Differentiation Response To Steroid Hormone Helper T Cell Diapedesis Leukocyte Migration Positive Regulation Of Protein Localization Protein Phosphorylated Amino Acid Binding Response To Cholecystokinin	Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Vesicle Scission Clathrin Coat Assembly Involved In Endocytosis Platelet-activating Factor Acetyltransferase Activity 1-alkyl-2-acetylglycerophosphocholine Esterase Complex Extrinsic Apoptotic Signaling Pathway Death-inducing Signaling Complex Assembly TRAIL Receptor Activity Death Receptor Activity Chromaffin Granule Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Adenylate Cyclase Activator Activity TRAIL Binding Response To Mechanical Stimulus 1-alkyl-2-acetylglycerophosphocholine Esterase Activity Positive Regulation Of Phosphorylation ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Positive Regulation Of Protein Phosphorylation TRAIL-activated Apoptotic Signaling Pathway Defense Response To Tumor Cell Activation Of NF-kappaB-inducing Kinase Activity
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