MINK1 and TUBA1B

Number of citations of the paper that reports this interaction (PubMedID 15032605)
0

Data Source:
HPRD (two hybrid)

		MINK1	TUBA1B
Description		misshapen like kinase 1	tubulin alpha 1b
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Postsynaptic Density Axon Dendrite Cell Projection Synapse Extracellular Exosome	Cytoplasm Cytoskeleton Microtubule Cytoplasmic Microtubule Cilium Microtubule Cytoskeleton
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Nucleotide Binding Double-stranded RNA Binding GTPase Activity Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Hydrolase Activity Ubiquitin Protein Ligase Binding
	Biological Process	MAPK Cascade Regulation Of Cell-matrix Adhesion Protein Phosphorylation JNK Cascade Chemical Synaptic Transmission Brain Development Regulation Of Cell-cell Adhesion Actin Cytoskeleton Organization Regulation Of Cell Migration Intracellular Signal Transduction Regulation Of MAPK Cascade Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Protein Autophosphorylation Neuron Projection Morphogenesis Dendrite Morphogenesis Positive Regulation Of P38MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Regulation Of AMPA Receptor Activity	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Cytoskeleton-dependent Intracellular Transport Cell Division Cellular Response To Interleukin-4
Pathways		Oxidative Stress Induced Senescence	Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Recruitment of NuMA to mitotic centrosomes Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin RHOH GTPase cycle HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling
Drugs		Fostamatinib	Epothilone D Patupilone CYT997 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE
Diseases
GWAS		Intracranial aneurysm ( 30823506) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Multiple sclerosis ( 31604244) Neutrophil percentage of white cells ( 32888494) PR interval ( 32439900)	Ambidextrousness ( 32989287) Bipolar disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Left-handedness ( 32989287) Left–right brain asymmetry ( 33723403)
Interacting Genes		17 interacting genes: ABI1 ACTA2 CALM3 CASKIN1 KIFAP3 LATS1 MAP1B NCK1 NEDD4L NEFM PKP4 SPTBN2 STRIP1 TUBA1B USP7 YWHAB YWHAZ	39 interacting genes: A2M AGTRAP EML4 EPN2 ESR1 FOXP1 FYN GRM7 GZMM HDAC6 ISG15 LINC00624 MAPT MINK1 MTCL1 MYC NFKBIA OGT PFDN5 PIK3R1 PSEN1 PTEN PTP4A1 PTPRF PXN RNF26 RSPH1 RUNX1 SIAH1 SLX1B SMAD2 SNAP91 SRPK2 SUMO2 TERT TMEM253 TOM1L1 TUBG1 WEE2-AS1
Entrez ID		50488	10376
HPRD ID		11366	03960
Ensembl ID		ENSG00000141503	ENSG00000123416
Uniprot IDs		Q8N4C8	P68363
PDB IDs			2E4H 5IJ0 5IJ9 5N5N 6E7B 6E7C 6I2I 6J4V 6J8O 6QUS 6QUY 6QVE 6QVJ 6S8L 7LXB 7M18 7M20 7PJF 7SJ7 7SJ8 7SJ9 7SJA 7Z6S 7ZCW 8T42 8U3Z 8V2J 8VA2 8VRJ 8VRK 8VT7 9BP6
Enriched GO Terms of Interacting Partners?		Cadherin Binding Regulation Of Postsynaptic Specialization Assembly Cytoskeleton Cytoplasm Glutamatergic Synapse Regulation Of Synapse Organization Protein Sequestering Activity Negative Regulation Of Protein Localization To Nucleus Phosphoserine Residue Binding Organelle Organization Negative Regulation Of Protein Localization Protein Kinase Binding Protein Domain Specific Binding Postsynapse Regulation Of Organelle Organization Regulation Of Postsynaptic Density Assembly Structural Constituent Of Cytoskeleton Cellular Component Assembly Regulation Of Excitatory Synapse Assembly Regulation Of Cellular Component Organization Regulation Of Actin Filament Polymerization Regulation Of Intracellular Signal Transduction Regulation Of Biological Quality Transmembrane Transporter Binding Growth Cone Regulation Of Postsynapse Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Actin Filament-based Process Spindle Pole Regulation Of Supramolecular Fiber Organization Regulation Of Protein Localization To Nucleus Regulation Of Cell Communication Regulation Of Signaling Regulation Of Synapse Assembly Negative Regulation Of Transport Structural Molecule Activity Regulation Of Protein-containing Complex Assembly Positive Regulation Of Hepatic Stellate Cell Contraction Spindle Microtubule Positive Regulation Of Protein-containing Complex Assembly Induction Of Synaptic Plasticity By Chemical Substance Cell Junction Organization Cytoskeleton-dependent Intracellular Transport Protein Kinase Inhibitor Activity Lamellipodium Organization Structural Constituent Of Synapse Postsynaptic Spectrin-associated Cytoskeleton Regulation Of Hippo Signaling Positive Regulation Of Calcium-dependent Cell-cell Adhesion	Negative Regulation Of Developmental Process Beta-catenin Binding Neuron Projection Organization Negative Regulation Of Cellular Component Organization Regulation Of Myeloid Cell Differentiation Regulation Of Cellular Component Organization Regulation Of Multicellular Organismal Development Negative Regulation Of Multicellular Organismal Process Regulation Of Developmental Process Regulation Of Signal Transduction Regulation Of Cell Development Regulation Of Cell Communication Regulation Of Signaling Response To Stress Regulation Of Anatomical Structure Morphogenesis Negative Regulation Of Cell Differentiation Regulation Of Protein Localization To Nucleus Enzyme Binding Negative Regulation Of Cell Development Positive Regulation Of Protein Oligomerization Negative Regulation Of Signal Transduction Negative Regulation Of Protein Metabolic Process Growth Factor Receptor Binding Dendritic Spine Organization Ubiquitin Protein Ligase Binding Negative Regulation Of Myeloid Cell Differentiation Organelle Organization Clathrin Binding Negative Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Cell Communication Negative Regulation Of Signaling Neuron Projection Development Positive Regulation Of Signaling Regulation Of Multicellular Organismal Process Neuron Projection Regulation Of Cell Differentiation Cellular Response To Reactive Oxygen Species Cellular Response To Stress Alpha-tubulin Binding Tau Protein Binding Postsynapse Organization Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Component Organization Regulation Of Protein Localization Negative Regulation Of Gene Expression Protein Modification Process Regulation Of Establishment Of Protein Localization Inclusion Body Assembly Regulation Of Myeloid Leukocyte Differentiation
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